Diagnosis of prodromal and Alzheimer's disease dementia in adults with Down syndrome using neuropsychological tests

Introduction: We aimed to define prodromal Alzheimer's disease (AD) and AD dementia using normative neuropsychological data in a large population-based cohort of adults with Down syndrome (DS). Methods: Cross-sectional study. DS participants were classified into asymptomatic, prodromal AD and A...

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Detalles Bibliográficos
Autores: Benejam, Bessy, Videla, Laura, Vilaplana, Eduard, Barroeta, Isabel, Carmona Iragui, María, Altuna, Miren, Valldeneu, Silvia, Fernández, Susana, Giménez, Sandra, Iulita, Maria Florencia, Garzón, Diana, Bejanin, Alexandre, Bartrés Faz, David, Videla, Sebastià, Alcolea, Daniel, Blesa González, Rafael, Lleó Bisa, Alberto, Fortea, Juan
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/195526
Acceso en línea:https://hdl.handle.net/2445/195526
Access Level:acceso abierto
Palabra clave:Síndrome de Down
Malaltia d'Alzheimer
Demència
Teràpia cognitiva
Tests neuropsicològics
Anàlisi de conducta
Down syndrome
Alzheimer's disease
Dementia
Cognitive therapy
Neuropsychological tests
Behavioral assessment
Descripción
Sumario:Introduction: We aimed to define prodromal Alzheimer's disease (AD) and AD dementia using normative neuropsychological data in a large population-based cohort of adults with Down syndrome (DS). Methods: Cross-sectional study. DS participants were classified into asymptomatic, prodromal AD and AD dementia, based on neurologist's judgment blinded to neuropsychological data (Cambridge Cognitive Examination for Older Adults with Down's syndrome [CAMCOG-DS] and modified Cued Recall Test [mCRT]). We compared the cutoffs derived from the normative data in young adults with DS to those from receiveroperating characteristic curve (ROC) analysis. Results: Diagnostic performance of the CAMCOG-DS and modified Cued Recall Test (mCRT) in subjects with mild and moderate levels of intellectual disability (ID) was high, both for diagnosing prodromal AD and AD dementia (area under the curve [AUC] 0.73- 0.83 and 0.90-1, respectively). The cutoffs derived from the normative data were similar to those derived from the ROC analyses. Discussion: Diagnosing prodromal AD and AD dementia in DS with mild and moderate ID using population norms for neuropsychological tests is possible with high diagnostic accuracy.

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