Evaluation of alternative vaccination routes against paratuberculosis in goats

16 páginas, 2 tablas, 3 figuras.

Detalles Bibliográficos
Autores: Criado, Miguel, Silva, Marta, Arteche-Villasol, Noive, Zapico, David, Elguezabal, Natalia, Molina, Elena, Espinosa Cerrato, José, Ferreras, Mª del Carmen, Benavides, Julio, Pérez, Valentín, Gutiérrez-Expósito, Daniel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/374965
Acceso en línea:http://hdl.handle.net/10261/374965
https://api.elsevier.com/content/abstract/scopus_id/85211584688
Access Level:acceso abierto
Palabra clave:Goat
Immunization strategies
Intradermal vaccin
Oral vaccine
Paratuberculosis
http://metadata.un.org/sdg/12
Ensure sustainable consumption and production patterns
paratuberculosis
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spelling Evaluation of alternative vaccination routes against paratuberculosis in goatsCriado, MiguelSilva, MartaArteche-Villasol, NoiveZapico, DavidElguezabal, NataliaMolina, ElenaEspinosa Cerrato, JoséFerreras, Mª del CarmenBenavides, JulioPérez, ValentínGutiérrez-Expósito, DanielGoatImmunization strategiesIntradermal vaccinOral vaccineParatuberculosishttp://metadata.un.org/sdg/12Ensure sustainable consumption and production patternsparatuberculosis16 páginas, 2 tablas, 3 figuras.Paratuberculosis is a chronic granulomatous enteritis, caused by Mycobacterium avium subspecies paratuberculosis (Map), that affects ruminants worldwide. Vaccination has been considered the most cost-effective method for the control of this disease in infected dairy herds. However, currently available vaccines do not provide complete protection and interfere with the diagnosis of both paratuberculosis and bovine tuberculosis, limiting its use. Because of that, efforts are being made for the development of new vaccines. The primary objective of this study was to evaluate the efficacy of two whole-cell inactivated experimental vaccines against paratuberculosis in goats, administered through the oral (OV) and intradermal (IDV) routes, and compare them with that of the commercial subcutaneous vaccine Gudair® (SCV). Over an 11-month period, the effect of vaccination and a subsequent Map challenge on the specific peripheral immune responses and Map-DNA fecal shedding were recorded. At the end of the experiment, tissue bacterial load and lesion severity were assessed. The experimental vaccines did not induce specific humoral immune responses and only elicited mild and delayed cellular immune responses. Although the OV reduced lesion severity, neither this vaccine nor the IDV prototype was able to reduce fecal shedding or tissue bacterial load. Moreover, although the SCV did not confer sterile immunity, it outperformed both experimental vaccines in all these parameters.The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This study was funded by the projects RTI2018-099496-B-I00 and PID2021-125807OB-C21, from the \u201CAgencia Estatal de Investigaci\u00F3n,\u201D of the Spanish Ministry of Science and Innovation. MC acknowledges the receipt of a pre-doctoral grant (PRE2019-087309) from MCIN/AEI/10.13039/501100011033 and FSE \u201CEl FSE invierte en tu futuro.\u201DPeer reviewedFrontiers MediaAgencia Estatal de Investigación (España)Ministerio de Ciencia e Innovación (España)European CommissionSilva Samos, Marta [0009-0006-1173-8344]Arteche Villasol, Noive [0000-0001-5793-9578]Ferreras Estrada, Mª del Carmen [0000-0003-1996-2229]Benavides, Julio [0000-0001-9706-100X]Pérez Pérez, Valentín [0000-0003-0075-1587]Gutiérrez Expósito, Daniel [0000-0002-7683-623X]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/374965https://api.elsevier.com/content/abstract/scopus_id/85211584688reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-099496-B-I00info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-125807OB-C21info:eu-repo/grantAgreement/AEI//PRE2019-087309The undelying dataset has been published as supplementary material of the article in the publisher platform at DOI 10.3389/fvets.2024.1457849http://dx.doi.org/doi.org/10.3389/fvets.2024.1457849Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3749652026-05-22T06:33:51Z
dc.title.none.fl_str_mv Evaluation of alternative vaccination routes against paratuberculosis in goats
title Evaluation of alternative vaccination routes against paratuberculosis in goats
spellingShingle Evaluation of alternative vaccination routes against paratuberculosis in goats
Criado, Miguel
Goat
Immunization strategies
Intradermal vaccin
Oral vaccine
Paratuberculosis
http://metadata.un.org/sdg/12
Ensure sustainable consumption and production patterns
paratuberculosis
title_short Evaluation of alternative vaccination routes against paratuberculosis in goats
title_full Evaluation of alternative vaccination routes against paratuberculosis in goats
title_fullStr Evaluation of alternative vaccination routes against paratuberculosis in goats
title_full_unstemmed Evaluation of alternative vaccination routes against paratuberculosis in goats
title_sort Evaluation of alternative vaccination routes against paratuberculosis in goats
dc.creator.none.fl_str_mv Criado, Miguel
Silva, Marta
Arteche-Villasol, Noive
Zapico, David
Elguezabal, Natalia
Molina, Elena
Espinosa Cerrato, José
Ferreras, Mª del Carmen
Benavides, Julio
Pérez, Valentín
Gutiérrez-Expósito, Daniel
author Criado, Miguel
author_facet Criado, Miguel
Silva, Marta
Arteche-Villasol, Noive
Zapico, David
Elguezabal, Natalia
Molina, Elena
Espinosa Cerrato, José
Ferreras, Mª del Carmen
Benavides, Julio
Pérez, Valentín
Gutiérrez-Expósito, Daniel
author_role author
author2 Silva, Marta
Arteche-Villasol, Noive
Zapico, David
Elguezabal, Natalia
Molina, Elena
Espinosa Cerrato, José
Ferreras, Mª del Carmen
Benavides, Julio
Pérez, Valentín
Gutiérrez-Expósito, Daniel
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Agencia Estatal de Investigación (España)
Ministerio de Ciencia e Innovación (España)
European Commission
Silva Samos, Marta [0009-0006-1173-8344]
Arteche Villasol, Noive [0000-0001-5793-9578]
Ferreras Estrada, Mª del Carmen [0000-0003-1996-2229]
Benavides, Julio [0000-0001-9706-100X]
Pérez Pérez, Valentín [0000-0003-0075-1587]
Gutiérrez Expósito, Daniel [0000-0002-7683-623X]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Goat
Immunization strategies
Intradermal vaccin
Oral vaccine
Paratuberculosis
http://metadata.un.org/sdg/12
Ensure sustainable consumption and production patterns
paratuberculosis
topic Goat
Immunization strategies
Intradermal vaccin
Oral vaccine
Paratuberculosis
http://metadata.un.org/sdg/12
Ensure sustainable consumption and production patterns
paratuberculosis
description 16 páginas, 2 tablas, 3 figuras.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/374965
https://api.elsevier.com/content/abstract/scopus_id/85211584688
url http://hdl.handle.net/10261/374965
https://api.elsevier.com/content/abstract/scopus_id/85211584688
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
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info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-099496-B-I00
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-125807OB-C21
info:eu-repo/grantAgreement/AEI//PRE2019-087309
The undelying dataset has been published as supplementary material of the article in the publisher platform at DOI 10.3389/fvets.2024.1457849
http://dx.doi.org/doi.org/10.3389/fvets.2024.1457849
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
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