Penetration enhancers for topical drug delivery to the ocular posterior segment: a systematic Review

There is an unmet clinical need for eye drop formulations to efficiently treat the diseases of the posterior ocular segment by non-invasive topical administration. Here, we systematically reviewed the literature on ocular penetration enhancers and their ability to transfer drugs to the posterior seg...

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Detalles Bibliográficos
Autores: Thareja, Abhinav, Hughes, Helen, Álvarez Lorenzo, Carmen, Hakkarainen, Jenni J., Ahmed, Zubair
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:minerva.usc.gal:10347/30388
Acceso en línea:http://hdl.handle.net/10347/30388
Access Level:acceso abierto
Palabra clave:Materias::Investigación::32 Ciencias médicas::3209 Farmacología::320901 Análisis de medicamentos
Materias::Investigación::32 Ciencias médicas::3209 Farmacología::320908 Preparación de medicamentos
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spelling Penetration enhancers for topical drug delivery to the ocular posterior segment: a systematic ReviewThareja, AbhinavHughes, HelenÁlvarez Lorenzo, CarmenHakkarainen, Jenni J.Ahmed, ZubairMaterias::Investigación::32 Ciencias médicas::3209 Farmacología::320901 Análisis de medicamentosMaterias::Investigación::32 Ciencias médicas::3209 Farmacología::320908 Preparación de medicamentosThere is an unmet clinical need for eye drop formulations to efficiently treat the diseases of the posterior ocular segment by non-invasive topical administration. Here, we systematically reviewed the literature on ocular penetration enhancers and their ability to transfer drugs to the posterior segment of the eye in experimental studies. Our aim was to assess which penetration enhancer is the most efficient at delivering drugs to the posterior segment of the eye, when topically applied. We conducted a comprehensive search in three electronic databases (Ovid Embase, Ovid MEDLINE, and PubMed) to identify all the relevant manuscripts reported on ocular penetration enhancers based on the PRISMA guidelines. We identified 6540 records from our primary database search and filtered them per our inclusion/exclusion criteria to select a final list of 14 articles for qualitative synthesis. Of these, 11 studies used cell penetrating peptides (CPPs), 2 used chitosan, and 1 used benzalkonium chloride (BAC) as the penetration enhancer. Cationic and amphipathic CPPs, transactivator of transcription (TAT), and penetratin can be inferred to be the best among all the identified penetration enhancers for drug delivery to the fundus oculi via topical eye drop instillation. Further high-quality experimental studies are required to ascertain their quantitative efficacyMDPIUniversidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica20212021-01-0120212021-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10347/30388reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostelainstname:Universidad de Santiago de Compostela (USC)InglésengEuropean Commission http://dx.doi.org/10.13039/501100000780 Horizon 2020 Framework Programme 813440-ORBITAL–Ocular Research by Integrated Training and Learningopen accesshttp://purl.org/coar/access_right/c_abf2© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses /by/4.0/)http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:minerva.usc.gal:10347/303882026-06-15T12:47:27Z
dc.title.none.fl_str_mv Penetration enhancers for topical drug delivery to the ocular posterior segment: a systematic Review
title Penetration enhancers for topical drug delivery to the ocular posterior segment: a systematic Review
spellingShingle Penetration enhancers for topical drug delivery to the ocular posterior segment: a systematic Review
Thareja, Abhinav
Materias::Investigación::32 Ciencias médicas::3209 Farmacología::320901 Análisis de medicamentos
Materias::Investigación::32 Ciencias médicas::3209 Farmacología::320908 Preparación de medicamentos
title_short Penetration enhancers for topical drug delivery to the ocular posterior segment: a systematic Review
title_full Penetration enhancers for topical drug delivery to the ocular posterior segment: a systematic Review
title_fullStr Penetration enhancers for topical drug delivery to the ocular posterior segment: a systematic Review
title_full_unstemmed Penetration enhancers for topical drug delivery to the ocular posterior segment: a systematic Review
title_sort Penetration enhancers for topical drug delivery to the ocular posterior segment: a systematic Review
dc.creator.none.fl_str_mv Thareja, Abhinav
Hughes, Helen
Álvarez Lorenzo, Carmen
Hakkarainen, Jenni J.
Ahmed, Zubair
author Thareja, Abhinav
author_facet Thareja, Abhinav
Hughes, Helen
Álvarez Lorenzo, Carmen
Hakkarainen, Jenni J.
Ahmed, Zubair
author_role author
author2 Hughes, Helen
Álvarez Lorenzo, Carmen
Hakkarainen, Jenni J.
Ahmed, Zubair
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica
dc.subject.none.fl_str_mv Materias::Investigación::32 Ciencias médicas::3209 Farmacología::320901 Análisis de medicamentos
Materias::Investigación::32 Ciencias médicas::3209 Farmacología::320908 Preparación de medicamentos
topic Materias::Investigación::32 Ciencias médicas::3209 Farmacología::320901 Análisis de medicamentos
Materias::Investigación::32 Ciencias médicas::3209 Farmacología::320908 Preparación de medicamentos
description There is an unmet clinical need for eye drop formulations to efficiently treat the diseases of the posterior ocular segment by non-invasive topical administration. Here, we systematically reviewed the literature on ocular penetration enhancers and their ability to transfer drugs to the posterior segment of the eye in experimental studies. Our aim was to assess which penetration enhancer is the most efficient at delivering drugs to the posterior segment of the eye, when topically applied. We conducted a comprehensive search in three electronic databases (Ovid Embase, Ovid MEDLINE, and PubMed) to identify all the relevant manuscripts reported on ocular penetration enhancers based on the PRISMA guidelines. We identified 6540 records from our primary database search and filtered them per our inclusion/exclusion criteria to select a final list of 14 articles for qualitative synthesis. Of these, 11 studies used cell penetrating peptides (CPPs), 2 used chitosan, and 1 used benzalkonium chloride (BAC) as the penetration enhancer. Cationic and amphipathic CPPs, transactivator of transcription (TAT), and penetratin can be inferred to be the best among all the identified penetration enhancers for drug delivery to the fundus oculi via topical eye drop instillation. Further high-quality experimental studies are required to ascertain their quantitative efficacy
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-01
2021
2021-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10347/30388
url http://hdl.handle.net/10347/30388
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv European Commission http://dx.doi.org/10.13039/501100000780 Horizon 2020 Framework Programme 813440-ORBITAL–Ocular Research by Integrated Training and Learning
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname:Universidad de Santiago de Compostela (USC)
instname_str Universidad de Santiago de Compostela (USC)
reponame_str Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
collection Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
repository.name.fl_str_mv
repository.mail.fl_str_mv
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