Role of chemokines and their receptors in viral persistence and liver damage during chronic hepatitis C virus infection

11 p.

Detalhes bibliográficos
Autores: Larrubia Marfil, Juan Ramón, Benito Martínez, Selma|||0000-0002-3118-0564, Calvino Fernández, Mirian, Sanz de Villalobos, Eduardo, Parra Cid, Trinidad
Formato: artículo
Fecha de publicación:2008
País:España
Recursos:Universidad de Alcalá (UAH)
Repositorio:e_Buah Biblioteca Digital Universidad de Alcalá
Idioma:inglés
OAI Identifier:oai:ebuah.uah.es:10017/59281
Acesso em linha:http://hdl.handle.net/10017/59281
https://dx.doi.org/10.3748/wjg.14.7149
Access Level:acceso abierto
Palavra-chave:Chemokines
Hepatitis C virus
Persistent infection
Viral escape mechanism
Viral hepatitis pathogenesis
Medicina
Medicine
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spelling Role of chemokines and their receptors in viral persistence and liver damage during chronic hepatitis C virus infectionLarrubia Marfil, Juan RamónBenito Martínez, Selma|||0000-0002-3118-0564Calvino Fernández, MirianSanz de Villalobos, EduardoParra Cid, TrinidadChemokinesHepatitis C virusPersistent infectionViral escape mechanismViral hepatitis pathogenesisMedicinaMedicine11 p.Chemokines produced in the liver during hepatitis C virus (HCV) infection induce migration of activated T cells from the periphery to infected parenchyma. The milieu of chemokines secreted by infected hepatocytes is predominantly associated with the T-helper/T-cytotoxic type-1 cell (Th1/Tc1) response. These chemokines consist of CCL3 (macrophage inflammatory protein-1?; MIP-1?), CCL4 (MIP- 1?) , CCL5 ( regulated on ac t ivat ion normal T cell expressed and secreted; RANTES), CXCL10 (interferon-??inducible protein-10; IP-10), CXCL11 (interferon-inducible T-cell ? chemoattractant; I-TAC), and CXCL9 (monokine induced by interferon ?; Mig) and they recruit T cells expressing either CCR5 or CXCR3 chemokine receptors. Intrahepatic and peripheral blood levels of these chemokines are increased during chronic hepatitis C. The interaction between chemokines and their receptors is essential in recruiting HCV-specific T cells to control the infection. When the adaptive immune response fails in this task, non-specific T cells without the capacity to control the infection are also recruited to the liver, and these are ultimately responsible for the persistent hepatic damage. The modulation of chemokine receptor expression and chemokine secretion could be a viral escape mechanism to avoid specific T cell migration to the liver during the early phase of infection, and to maintain liver viability during the chronic phase, by impairing non-specific T cell migration. Some chemokines and their receptors correlate with liver damage, and CXCL10 (IP-10) and CXCR3 levels have shown a clinical utility as predictors of treatment response outcome. The regulation of chemokines and their receptors could be a future potential therapeutic target to decrease liver inflammation and to increase specific T cell migration to the infected liver.Junta de Comunidades de Castilla-La ManchaFundación de Investigación Médica Mutua MadrileñaAsociación Castellana de Aparato Digestivo20082008-01-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10017/59281https://dx.doi.org/10.3748/wjg.14.7149reponame:e_Buah Biblioteca Digital Universidad de Alcaláinstname:Universidad de Alcalá (UAH)InglésengJunta de Comunidades de Castilla-La Mancha http://dx.doi.org/10.13039/501100011698 Not available Not availableNot available Not available Not availableNot available Not available Not availableopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nd/4.0/info:eu-repo/semantics/openAccessoai:ebuah.uah.es:10017/592812026-06-18T11:13:07Z
dc.title.none.fl_str_mv Role of chemokines and their receptors in viral persistence and liver damage during chronic hepatitis C virus infection
title Role of chemokines and their receptors in viral persistence and liver damage during chronic hepatitis C virus infection
spellingShingle Role of chemokines and their receptors in viral persistence and liver damage during chronic hepatitis C virus infection
Larrubia Marfil, Juan Ramón
Chemokines
Hepatitis C virus
Persistent infection
Viral escape mechanism
Viral hepatitis pathogenesis
Medicina
Medicine
title_short Role of chemokines and their receptors in viral persistence and liver damage during chronic hepatitis C virus infection
title_full Role of chemokines and their receptors in viral persistence and liver damage during chronic hepatitis C virus infection
title_fullStr Role of chemokines and their receptors in viral persistence and liver damage during chronic hepatitis C virus infection
title_full_unstemmed Role of chemokines and their receptors in viral persistence and liver damage during chronic hepatitis C virus infection
title_sort Role of chemokines and their receptors in viral persistence and liver damage during chronic hepatitis C virus infection
dc.creator.none.fl_str_mv Larrubia Marfil, Juan Ramón
Benito Martínez, Selma|||0000-0002-3118-0564
Calvino Fernández, Mirian
Sanz de Villalobos, Eduardo
Parra Cid, Trinidad
author Larrubia Marfil, Juan Ramón
author_facet Larrubia Marfil, Juan Ramón
Benito Martínez, Selma|||0000-0002-3118-0564
Calvino Fernández, Mirian
Sanz de Villalobos, Eduardo
Parra Cid, Trinidad
author_role author
author2 Benito Martínez, Selma|||0000-0002-3118-0564
Calvino Fernández, Mirian
Sanz de Villalobos, Eduardo
Parra Cid, Trinidad
author2_role author
author
author
author
dc.subject.none.fl_str_mv Chemokines
Hepatitis C virus
Persistent infection
Viral escape mechanism
Viral hepatitis pathogenesis
Medicina
Medicine
topic Chemokines
Hepatitis C virus
Persistent infection
Viral escape mechanism
Viral hepatitis pathogenesis
Medicina
Medicine
description 11 p.
publishDate 2008
dc.date.none.fl_str_mv 2008
2008-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10017/59281
https://dx.doi.org/10.3748/wjg.14.7149
url http://hdl.handle.net/10017/59281
https://dx.doi.org/10.3748/wjg.14.7149
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Junta de Comunidades de Castilla-La Mancha http://dx.doi.org/10.13039/501100011698 Not available Not available
Not available Not available Not available
Not available Not available Not available
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:e_Buah Biblioteca Digital Universidad de Alcalá
instname:Universidad de Alcalá (UAH)
instname_str Universidad de Alcalá (UAH)
reponame_str e_Buah Biblioteca Digital Universidad de Alcalá
collection e_Buah Biblioteca Digital Universidad de Alcalá
repository.name.fl_str_mv
repository.mail.fl_str_mv
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