Safety assessment of propyl-propane-thiosulfonate (PTSO): 90-days oral subchronic toxicity study in rats

Propyl-propane-thiosulfonate (PTSO) is one of the main organosulfur compounds present in Allium essentials oil. Different applications in the food sector have been proposed for PTSO, such as food and feed additive and as active packaging. However, the authorization of its use depends on its toxicity...

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Autores: Cascajosa Lira, Antonio, Prieto Ortega, Ana Isabel, Baños, Alberto, Guillamón, Enrique, Moyano, Rosario, Jos Gallego, Ángeles Mencía, Cameán Fernández, Ana María
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2020
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/128501
Acceso en línea:https://hdl.handle.net/11441/128501
https://doi.org/10.1016/j.fct.2020.111612
Access Level:acceso abierto
Palabra clave:Subchronic toxicity
90-day
Organosulfur compounds
Allium
Propyl-propanethiosulfonate
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spelling Safety assessment of propyl-propane-thiosulfonate (PTSO): 90-days oral subchronic toxicity study in ratsCascajosa Lira, AntonioPrieto Ortega, Ana IsabelBaños, AlbertoGuillamón, EnriqueMoyano, RosarioJos Gallego, Ángeles MencíaCameán Fernández, Ana MaríaSubchronic toxicity90-dayOrganosulfur compoundsAlliumPropyl-propanethiosulfonatePropyl-propane-thiosulfonate (PTSO) is one of the main organosulfur compounds present in Allium essentials oil. Different applications in the food sector have been proposed for PTSO, such as food and feed additive and as active packaging. However, the authorization of its use depends on its toxicity profile. Thus, as a part of its safety assessment, in this work a repeated dose 90-day oral toxicity study has been conducted for the first time in rats following the OECD guideline 408. PTSO was administered to groups of 10 male and 10 female rats at dose levels of 0, 14, 28, and 55 mg/kg/day. No clinical signs or mortality and no changes in body weight, food consumption and feed conversion efficiency were detected through the study. Moreover, no treatment-related changes in hematological and biochemical parameters were observed, for either sex or dose groups. The histopathology study performed revealed no differences in organ weights, and no morphological and histopathological changes were observed. Based on these results, the no-observed-adverse-effect level (NOAEL) of PTSO was judged to be ≥ 55 mg/kg/day for both sexes.Ministerio de Ciencia e Innovación (Project RTC-2017-6199-2)Junta de Andalucía (Project AT 2017-5323)ElsevierNutrición y Bromatología, Toxicología y Medicina LegalMinisterio de Ciencia e Innovación (MICIN). EspañaJunta de Andalucía2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/128501https://doi.org/10.1016/j.fct.2020.111612reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésFood and Chemical Toxicology, 144, 111612.RTC-2017-6199-2AT 2017-5323https://doi.org/10.1016/j.fct.2020.111612info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1285012026-06-17T12:51:07Z
dc.title.none.fl_str_mv Safety assessment of propyl-propane-thiosulfonate (PTSO): 90-days oral subchronic toxicity study in rats
title Safety assessment of propyl-propane-thiosulfonate (PTSO): 90-days oral subchronic toxicity study in rats
spellingShingle Safety assessment of propyl-propane-thiosulfonate (PTSO): 90-days oral subchronic toxicity study in rats
Cascajosa Lira, Antonio
Subchronic toxicity
90-day
Organosulfur compounds
Allium
Propyl-propanethiosulfonate
title_short Safety assessment of propyl-propane-thiosulfonate (PTSO): 90-days oral subchronic toxicity study in rats
title_full Safety assessment of propyl-propane-thiosulfonate (PTSO): 90-days oral subchronic toxicity study in rats
title_fullStr Safety assessment of propyl-propane-thiosulfonate (PTSO): 90-days oral subchronic toxicity study in rats
title_full_unstemmed Safety assessment of propyl-propane-thiosulfonate (PTSO): 90-days oral subchronic toxicity study in rats
title_sort Safety assessment of propyl-propane-thiosulfonate (PTSO): 90-days oral subchronic toxicity study in rats
dc.creator.none.fl_str_mv Cascajosa Lira, Antonio
Prieto Ortega, Ana Isabel
Baños, Alberto
Guillamón, Enrique
Moyano, Rosario
Jos Gallego, Ángeles Mencía
Cameán Fernández, Ana María
author Cascajosa Lira, Antonio
author_facet Cascajosa Lira, Antonio
Prieto Ortega, Ana Isabel
Baños, Alberto
Guillamón, Enrique
Moyano, Rosario
Jos Gallego, Ángeles Mencía
Cameán Fernández, Ana María
author_role author
author2 Prieto Ortega, Ana Isabel
Baños, Alberto
Guillamón, Enrique
Moyano, Rosario
Jos Gallego, Ángeles Mencía
Cameán Fernández, Ana María
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Nutrición y Bromatología, Toxicología y Medicina Legal
Ministerio de Ciencia e Innovación (MICIN). España
Junta de Andalucía
dc.subject.none.fl_str_mv Subchronic toxicity
90-day
Organosulfur compounds
Allium
Propyl-propanethiosulfonate
topic Subchronic toxicity
90-day
Organosulfur compounds
Allium
Propyl-propanethiosulfonate
description Propyl-propane-thiosulfonate (PTSO) is one of the main organosulfur compounds present in Allium essentials oil. Different applications in the food sector have been proposed for PTSO, such as food and feed additive and as active packaging. However, the authorization of its use depends on its toxicity profile. Thus, as a part of its safety assessment, in this work a repeated dose 90-day oral toxicity study has been conducted for the first time in rats following the OECD guideline 408. PTSO was administered to groups of 10 male and 10 female rats at dose levels of 0, 14, 28, and 55 mg/kg/day. No clinical signs or mortality and no changes in body weight, food consumption and feed conversion efficiency were detected through the study. Moreover, no treatment-related changes in hematological and biochemical parameters were observed, for either sex or dose groups. The histopathology study performed revealed no differences in organ weights, and no morphological and histopathological changes were observed. Based on these results, the no-observed-adverse-effect level (NOAEL) of PTSO was judged to be ≥ 55 mg/kg/day for both sexes.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/128501
https://doi.org/10.1016/j.fct.2020.111612
url https://hdl.handle.net/11441/128501
https://doi.org/10.1016/j.fct.2020.111612
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Food and Chemical Toxicology, 144, 111612.
RTC-2017-6199-2
AT 2017-5323
https://doi.org/10.1016/j.fct.2020.111612
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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