Determination of nicotine in e-liquids by electrochemical generation of surface-enhanced Raman scattering substrates

Quantitative methods using surface-enhanced Raman scattering (SERS) for analysis in complex matrices are very attractive due to the high sensitivity and selectivity of this technique. In this work, a novel time-resolved elec trochemical surface-enhanced Raman scattering (TR-EC-SERS) analytical metho...

Descripción completa

Detalles Bibliográficos
Autores: Romay García, Luis, Pérez Estébanez, Martín, Heras Vidaurre, Aránzazu, Colina Santamaría, Álvaro
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Universidad de Burgos (UBU)
Repositorio:Repositorio Institucional de la Universidad de Burgos (RIUBU)
OAI Identifier:oai:riubu.ubu.es:10259/10194
Acceso en línea:http://hdl.handle.net/10259/10194
Access Level:acceso abierto
Palabra clave:SERS
Spectroelectrochemistry
PARAFAC
Nicotine
E-liquid
Química analítica
Electroquímica
Chemistry, Analytic
Electrochemistry
id ES_3d61cd89e54df3d037c016571df5cf44
oai_identifier_str oai:riubu.ubu.es:10259/10194
network_acronym_str ES
network_name_str España
repository_id_str
spelling Determination of nicotine in e-liquids by electrochemical generation of surface-enhanced Raman scattering substratesRomay García, LuisPérez Estébanez, MartínHeras Vidaurre, AránzazuColina Santamaría, ÁlvaroSERSSpectroelectrochemistryPARAFACNicotineE-liquidQuímica analíticaElectroquímicaChemistry, AnalyticElectrochemistryQuantitative methods using surface-enhanced Raman scattering (SERS) for analysis in complex matrices are very attractive due to the high sensitivity and selectivity of this technique. In this work, a novel time-resolved elec trochemical surface-enhanced Raman scattering (TR-EC-SERS) analytical method has been developed for the determination of nicotine in e-liquids of electronic cigarettes. One of the main challenges of SERS is its inherent lack of reproducibility. Here, this limitation was mitigated by employing an electrochemical pre-treatment step to generate a homogeneous distribution of silver nanoparticles (Ag-NPs) on a silver screen-printed electrode. The enhanced Raman scattering induced by the Ag-NPs enabled the detection of nicotine at nanomolar levels. The high sensitivity of the method allowed the quantitative analysis of diluted e-liquid samples, mitigating potential interferences from other components present in these complex matrices. Moreover, TR-EC-SERS, coupled with parallel factor analysis (PARAFAC), demonstrated the capability of trilinear spectroelectrochemistry data not only to detect nicotine but also to identify potential interfering compounds without prior knowledge of their spectral signatures. This multivariate approach offers significant potential for the detection of outliers in complex samples.Ministerio de Ciencia e Innovacion ´ and Agencia Estatal de Investigacion ´ (MCIN/AEI/10.13039/501100011033, PID2020-113154RBC21, PID2023-149188OB-I00) and FEDER, UE, Junta de Castilla y Leon ´ and European Regional Development Fund (Grant number: BU036P23), Ministerio de Ciencia, Innovacion ´ y Universidades (RED2022-134120-T) are gratefully acknowledged for funding this work. L.R. acknowledges Ministerio de Ciencia e Innovacion ´ and Agencia Estatal de Investigacion ´ (MCIN/AEI/ 10.13039/ 501100011033, PIS2020-113154 GB-C21) for the predoctoral contractElsevier202520252025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10259/10194reponame:Repositorio Institucional de la Universidad de Burgos (RIUBU)instname:Universidad de Burgos (UBU)InglésMicrochemical Journal. 2025, V. 208, p. 112551https://doi.org/10.1016/j.microc.2024.112551info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica, Técnica y de Innovación 2017-2020/PID2020-113154RB-C21info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica, Técnica y de Innovación 2021-2023/PID2023-149188OB-I00info:eu-repo/grantAgreement/Junta de Castilla y León//BU036P23info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica, Técnica y de Innovación 2021-2023/RED2022-134120-TAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:riubu.ubu.es:10259/101942026-05-28T07:56:11Z
dc.title.none.fl_str_mv Determination of nicotine in e-liquids by electrochemical generation of surface-enhanced Raman scattering substrates
title Determination of nicotine in e-liquids by electrochemical generation of surface-enhanced Raman scattering substrates
spellingShingle Determination of nicotine in e-liquids by electrochemical generation of surface-enhanced Raman scattering substrates
Romay García, Luis
SERS
Spectroelectrochemistry
PARAFAC
Nicotine
E-liquid
Química analítica
Electroquímica
Chemistry, Analytic
Electrochemistry
title_short Determination of nicotine in e-liquids by electrochemical generation of surface-enhanced Raman scattering substrates
title_full Determination of nicotine in e-liquids by electrochemical generation of surface-enhanced Raman scattering substrates
title_fullStr Determination of nicotine in e-liquids by electrochemical generation of surface-enhanced Raman scattering substrates
title_full_unstemmed Determination of nicotine in e-liquids by electrochemical generation of surface-enhanced Raman scattering substrates
title_sort Determination of nicotine in e-liquids by electrochemical generation of surface-enhanced Raman scattering substrates
dc.creator.none.fl_str_mv Romay García, Luis
Pérez Estébanez, Martín
Heras Vidaurre, Aránzazu
Colina Santamaría, Álvaro
author Romay García, Luis
author_facet Romay García, Luis
Pérez Estébanez, Martín
Heras Vidaurre, Aránzazu
Colina Santamaría, Álvaro
author_role author
author2 Pérez Estébanez, Martín
Heras Vidaurre, Aránzazu
Colina Santamaría, Álvaro
author2_role author
author
author
dc.subject.none.fl_str_mv SERS
Spectroelectrochemistry
PARAFAC
Nicotine
E-liquid
Química analítica
Electroquímica
Chemistry, Analytic
Electrochemistry
topic SERS
Spectroelectrochemistry
PARAFAC
Nicotine
E-liquid
Química analítica
Electroquímica
Chemistry, Analytic
Electrochemistry
description Quantitative methods using surface-enhanced Raman scattering (SERS) for analysis in complex matrices are very attractive due to the high sensitivity and selectivity of this technique. In this work, a novel time-resolved elec trochemical surface-enhanced Raman scattering (TR-EC-SERS) analytical method has been developed for the determination of nicotine in e-liquids of electronic cigarettes. One of the main challenges of SERS is its inherent lack of reproducibility. Here, this limitation was mitigated by employing an electrochemical pre-treatment step to generate a homogeneous distribution of silver nanoparticles (Ag-NPs) on a silver screen-printed electrode. The enhanced Raman scattering induced by the Ag-NPs enabled the detection of nicotine at nanomolar levels. The high sensitivity of the method allowed the quantitative analysis of diluted e-liquid samples, mitigating potential interferences from other components present in these complex matrices. Moreover, TR-EC-SERS, coupled with parallel factor analysis (PARAFAC), demonstrated the capability of trilinear spectroelectrochemistry data not only to detect nicotine but also to identify potential interfering compounds without prior knowledge of their spectral signatures. This multivariate approach offers significant potential for the detection of outliers in complex samples.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10259/10194
url http://hdl.handle.net/10259/10194
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Microchemical Journal. 2025, V. 208, p. 112551
https://doi.org/10.1016/j.microc.2024.112551
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica, Técnica y de Innovación 2017-2020/PID2020-113154RB-C21
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica, Técnica y de Innovación 2021-2023/PID2023-149188OB-I00
info:eu-repo/grantAgreement/Junta de Castilla y León//BU036P23
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica, Técnica y de Innovación 2021-2023/RED2022-134120-T
dc.rights.none.fl_str_mv Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositorio Institucional de la Universidad de Burgos (RIUBU)
instname:Universidad de Burgos (UBU)
instname_str Universidad de Burgos (UBU)
reponame_str Repositorio Institucional de la Universidad de Burgos (RIUBU)
collection Repositorio Institucional de la Universidad de Burgos (RIUBU)
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869406436312743936
score 15,812429

Similares en LA Referencia