Transcriptional regulation of neuronal identity

16 páginas, 2 figuras

Detalles Bibliográficos
Autores: Sousa, Erick, Flames, Nuria
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/264362
Acceso en línea:http://hdl.handle.net/10261/264362
Access Level:acceso abierto
Palabra clave:Enhancers
Neuronal differentiation
Neuronal identity
Regulation of gene expression
Regulatory genome
Repression
Transcription factor
id ES_3d48cb5dd26ff91b44b98d2be041da94
oai_identifier_str oai:digital.csic.es:10261/264362
network_acronym_str ES
network_name_str España
repository_id_str
spelling Transcriptional regulation of neuronal identitySousa, ErickFlames, NuriaEnhancersNeuronal differentiationNeuronal identityRegulation of gene expressionRegulatory genomeRepressionTranscription factor16 páginas, 2 figurasNeuronal diversity is an intrinsic feature of the nervous system. Transcription factors (TFs) are key regulators in the establishment of different neuronal identities; how are the actions of different TFs coordinated to orchestrate this diversity? Are there common features shared among the different neuron types of an organism or even among different animal groups? In this review, we provide a brief overview on common traits emerging on the transcriptional regulation of neuron type diversification with a special focus on the comparison between mouse and Caenorhabditis elegans model systems. In the first part, we describe general concepts on neuronal identity and transcriptional regulation of gene expression. In the second part of the review, TFs are classified in different categories according to their key roles at specific steps along the protracted process of neuronal specification and differentiation. The same TF categories can be identified both in mammals and nematodes. Importantly, TFs are very pleiotropic: Depending on the neuron type or the time in development, the same TF can fulfil functions belonging to different categories. Finally, we describe the key role of transcriptional repression at all steps controlling neuronal diversity and propose that acquisition of neuronal identities could be considered a metastable process.Our work is funded by H2020 European Research Council (COG-101002203), Ministerio de Ciencia e Innovacion (PID2020-115635RB- I00 and RED2018-102553-T) and Generalitat Valenciana (PROMETEO/2018/055 and PhD fellowship ACIF/2019/079 to E. Sousa)Peer reviewedWiley-BlackwellFederation of European Neuroscience SocietiesEuropean Research CouncilMinisterio de Ciencia e Innovación (España)Generalitat ValencianaFlames, Nuria [0000-0003-0961-0609]Sousa, Erick [0000-0002-7412-0430]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202220222022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bcPublisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/264362reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/EC/H2020/101002203info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020MICIU/ICTI2017‐2020info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020MICIU/ICTI2017‐2020https://dx.doi.org/10.1111/ejn.15551Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2643622026-05-22T06:33:51Z
dc.title.none.fl_str_mv Transcriptional regulation of neuronal identity
title Transcriptional regulation of neuronal identity
spellingShingle Transcriptional regulation of neuronal identity
Sousa, Erick
Enhancers
Neuronal differentiation
Neuronal identity
Regulation of gene expression
Regulatory genome
Repression
Transcription factor
title_short Transcriptional regulation of neuronal identity
title_full Transcriptional regulation of neuronal identity
title_fullStr Transcriptional regulation of neuronal identity
title_full_unstemmed Transcriptional regulation of neuronal identity
title_sort Transcriptional regulation of neuronal identity
dc.creator.none.fl_str_mv Sousa, Erick
Flames, Nuria
author Sousa, Erick
author_facet Sousa, Erick
Flames, Nuria
author_role author
author2 Flames, Nuria
author2_role author
dc.contributor.none.fl_str_mv European Research Council
Ministerio de Ciencia e Innovación (España)
Generalitat Valenciana
Flames, Nuria [0000-0003-0961-0609]
Sousa, Erick [0000-0002-7412-0430]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Enhancers
Neuronal differentiation
Neuronal identity
Regulation of gene expression
Regulatory genome
Repression
Transcription factor
topic Enhancers
Neuronal differentiation
Neuronal identity
Regulation of gene expression
Regulatory genome
Repression
Transcription factor
description 16 páginas, 2 figuras
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_dcae04bc
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/264362
url http://hdl.handle.net/10261/264362
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/EC/H2020/101002203
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020MICIU/ICTI2017‐2020
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020MICIU/ICTI2017‐2020
https://dx.doi.org/10.1111/ejn.15551
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley-Blackwell
Federation of European Neuroscience Societies
publisher.none.fl_str_mv Wiley-Blackwell
Federation of European Neuroscience Societies
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869406430031773696
score 15.812429

Similares en LA Referencia