Gender differences in health-related quality of life in patients with systolic heart failure: results of the VIDA multicenter study

Previous studies have shown that heart failure is associated with worse health-related quality of life (HRQoL). The existence of differences according to gender remains controversial. We studied 1028 consecutive outpatients with heart failure and reduced ejection fraction (HFrEF) from a multicentre...

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Autores: Garay, Alberto, Tapia, Javier, Anguita, Manuel, Formiga, Francesc, Almenar, Luis, Crespo-Leiro, María G., Manzano, Luis, Muñiz, Javier, Chaves, José, De Frutos, Trinidad, Moliner, Pedro, Corbella Virós, Xavier, Enjuanes-Grau, Cristina, Comin-Colet, Josep, VIDA-IC Multicenter Study Investigators
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:20.500.12328/1807
Acceso en línea:http://hdl.handle.net/20.500.12328/1807
https://dx.doi.org/10.3390/jcm9092825
Access Level:acceso abierto
Palabra clave:Cardiologia
Insuficiència cardíaca
Qualitat de vida
Cardiología
Insuficiencia cardíaca
Calidad de vida
Cardiology
Heart failure
Life, Quality of
61
616.1
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spelling Gender differences in health-related quality of life in patients with systolic heart failure: results of the VIDA multicenter studyGaray, AlbertoTapia, JavierAnguita, ManuelFormiga, FrancescAlmenar, LuisCrespo-Leiro, María G.Manzano, LuisMuñiz, JavierChaves, JoséDe Frutos, TrinidadMoliner, PedroCorbella Virós, XavierEnjuanes-Grau, CristinaComin-Colet, JosepVIDA-IC Multicenter Study InvestigatorsCardiologiaInsuficiència cardíacaQualitat de vidaCardiologíaInsuficiencia cardíacaCalidad de vidaCardiologyHeart failureLife, Quality of61616.1Previous studies have shown that heart failure is associated with worse health-related quality of life (HRQoL). The existence of differences according to gender remains controversial. We studied 1028 consecutive outpatients with heart failure and reduced ejection fraction (HFrEF) from a multicentre cross-sectional descriptive study across Spain that assessed HRQoL using two questionnaires (KCCQ, Kansas City Cardiomyopathy Questionnaire; and EQ-5D, EuroQoL 5 dimensions). The primary objective of the study was to describe differences in HRQoL between men and women in global scores and domains of health status of patients and explore gender differences and its interactions with heart failure related factors. In adjusted analysis women had lower scores in KCCQ overall summary scores when compared to men denoting worse HRQoL (54.7 ± 1.3 vs. 62.7 ± 0.8, p < 0.0001), and specifically got lower score in domains of symptom frequency, symptoms burden, physical limitation, quality of life and social limitation. No differences were found in domains of symptom stability and self-efficacy. Women also had lower scores on all items of EQ-5D (EQ-5D index 0.58 ± 0.01 vs. 0.67 ± 0.01, p < 0.0001). Finally, we analyzed interaction between gender and different clinical determinants regarding the presence of limitations in the 5Q-5D and overall summary score of KCCQ. Interestingly, there was no statistical significance for interaction for any variable. In conclusion, women with HFrEF have worse HRQoL compared to men. These differences do not appear to be mediated by clinical or biological factors classically associated with HRQoL nor with heart failure severity.info:eu-repo/semantics/publishedVersionMDPI2020info:eu-repo/semantics/article14http://hdl.handle.net/20.500.12328/1807https://dx.doi.org/10.3390/jcm9092825reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésJournal of Clinical Medicine9;9© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).http://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessoai:recercat.cat:20.500.12328/18072026-05-29T05:05:01Z
dc.title.none.fl_str_mv Gender differences in health-related quality of life in patients with systolic heart failure: results of the VIDA multicenter study
title Gender differences in health-related quality of life in patients with systolic heart failure: results of the VIDA multicenter study
spellingShingle Gender differences in health-related quality of life in patients with systolic heart failure: results of the VIDA multicenter study
Garay, Alberto
Cardiologia
Insuficiència cardíaca
Qualitat de vida
Cardiología
Insuficiencia cardíaca
Calidad de vida
Cardiology
Heart failure
Life, Quality of
61
616.1
title_short Gender differences in health-related quality of life in patients with systolic heart failure: results of the VIDA multicenter study
title_full Gender differences in health-related quality of life in patients with systolic heart failure: results of the VIDA multicenter study
title_fullStr Gender differences in health-related quality of life in patients with systolic heart failure: results of the VIDA multicenter study
title_full_unstemmed Gender differences in health-related quality of life in patients with systolic heart failure: results of the VIDA multicenter study
title_sort Gender differences in health-related quality of life in patients with systolic heart failure: results of the VIDA multicenter study
dc.creator.none.fl_str_mv Garay, Alberto
Tapia, Javier
Anguita, Manuel
Formiga, Francesc
Almenar, Luis
Crespo-Leiro, María G.
Manzano, Luis
Muñiz, Javier
Chaves, José
De Frutos, Trinidad
Moliner, Pedro
Corbella Virós, Xavier
Enjuanes-Grau, Cristina
Comin-Colet, Josep
VIDA-IC Multicenter Study Investigators
author Garay, Alberto
author_facet Garay, Alberto
Tapia, Javier
Anguita, Manuel
Formiga, Francesc
Almenar, Luis
Crespo-Leiro, María G.
Manzano, Luis
Muñiz, Javier
Chaves, José
De Frutos, Trinidad
Moliner, Pedro
Corbella Virós, Xavier
Enjuanes-Grau, Cristina
Comin-Colet, Josep
VIDA-IC Multicenter Study Investigators
author_role author
author2 Tapia, Javier
Anguita, Manuel
Formiga, Francesc
Almenar, Luis
Crespo-Leiro, María G.
Manzano, Luis
Muñiz, Javier
Chaves, José
De Frutos, Trinidad
Moliner, Pedro
Corbella Virós, Xavier
Enjuanes-Grau, Cristina
Comin-Colet, Josep
VIDA-IC Multicenter Study Investigators
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cardiologia
Insuficiència cardíaca
Qualitat de vida
Cardiología
Insuficiencia cardíaca
Calidad de vida
Cardiology
Heart failure
Life, Quality of
61
616.1
topic Cardiologia
Insuficiència cardíaca
Qualitat de vida
Cardiología
Insuficiencia cardíaca
Calidad de vida
Cardiology
Heart failure
Life, Quality of
61
616.1
description Previous studies have shown that heart failure is associated with worse health-related quality of life (HRQoL). The existence of differences according to gender remains controversial. We studied 1028 consecutive outpatients with heart failure and reduced ejection fraction (HFrEF) from a multicentre cross-sectional descriptive study across Spain that assessed HRQoL using two questionnaires (KCCQ, Kansas City Cardiomyopathy Questionnaire; and EQ-5D, EuroQoL 5 dimensions). The primary objective of the study was to describe differences in HRQoL between men and women in global scores and domains of health status of patients and explore gender differences and its interactions with heart failure related factors. In adjusted analysis women had lower scores in KCCQ overall summary scores when compared to men denoting worse HRQoL (54.7 ± 1.3 vs. 62.7 ± 0.8, p < 0.0001), and specifically got lower score in domains of symptom frequency, symptoms burden, physical limitation, quality of life and social limitation. No differences were found in domains of symptom stability and self-efficacy. Women also had lower scores on all items of EQ-5D (EQ-5D index 0.58 ± 0.01 vs. 0.67 ± 0.01, p < 0.0001). Finally, we analyzed interaction between gender and different clinical determinants regarding the presence of limitations in the 5Q-5D and overall summary score of KCCQ. Interestingly, there was no statistical significance for interaction for any variable. In conclusion, women with HFrEF have worse HRQoL compared to men. These differences do not appear to be mediated by clinical or biological factors classically associated with HRQoL nor with heart failure severity.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12328/1807
https://dx.doi.org/10.3390/jcm9092825
url http://hdl.handle.net/20.500.12328/1807
https://dx.doi.org/10.3390/jcm9092825
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Journal of Clinical Medicine
9;9
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 14
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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