Recommendations for the study of monoclonal gammopathies in the clinical laboratory. A consensus of the Spanish Society of Laboratory Medicine and the Spanish Society of Hematology and Hemotherapy. Part I: Update on laboratory tests for the study of monoclonal gammopathies

Monoclonal gammopathies (MG) are characterized by the proliferation of plasma cells that produce identical abnormal immunoglobulins (intact or some of their subunits). This abnormal immunoglobulin component is called monoclonal protein (M-protein), and is considered a biomarker of proliferative acti...

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Autores: Cárdenas, María C., García-Sanz, Ramón, Puig, Noemi, Pérez-Surribas, David, Flores-Montero, Juan, Ortiz-Espejo, María, Rubia, Javier de la, Cruz-Iglesias, Elena
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/352621
Acceso en línea:http://hdl.handle.net/10261/352621
Access Level:acceso abierto
Palabra clave:Bone marrow
Electrophoresis
Capillary
Immunofixation
In situ hybridization
Fluorescence
Monoclonal gammopathy of undetermined significance
Multiple myeloma
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spelling Recommendations for the study of monoclonal gammopathies in the clinical laboratory. A consensus of the Spanish Society of Laboratory Medicine and the Spanish Society of Hematology and Hemotherapy. Part I: Update on laboratory tests for the study of monoclonal gammopathiesCárdenas, María C.García-Sanz, RamónPuig, NoemiPérez-Surribas, DavidFlores-Montero, JuanOrtiz-Espejo, MaríaRubia, Javier de laCruz-Iglesias, ElenaBone marrowElectrophoresisCapillaryImmunofixationIn situ hybridizationFluorescenceMonoclonal gammopathy of undetermined significanceMultiple myelomaMonoclonal gammopathies (MG) are characterized by the proliferation of plasma cells that produce identical abnormal immunoglobulins (intact or some of their subunits). This abnormal immunoglobulin component is called monoclonal protein (M-protein), and is considered a biomarker of proliferative activity. The identification, characterization and measurement of M-protein is essential for the management of MG. We conducted a systematic review of the different tests and measurement methods used in the clinical laboratory for the study of M-protein in serum and urine, the biochemistry and hematology tests necessary for clinical evaluation, and studies in bone marrow, peripheral blood and other tissues. This review included literature published between 2009 and 2022. The paper discusses the main methodological characteristics and limitations, as well as the purpose and clinical value of the different tests used in the diagnosis, prognosis, monitoring and assessment of treatment response in MG. Included are methods for the study of M-protein, namely electrophoresis, measurement of immunoglobulin levels, serum free light chains, immunoglobulin heavy chain/light chain pairs, and mass spectrometry, and for the bone marrow examination, morphological analysis, cytogenetics, molecular techniques, and multiparameter flow cytometry.Research funding: Novartis, Gilead, Astellas, Janssen.Peer reviewedWalter de GruyterNovartisGilead Research ScholarsAstellas PharmaJanssen Research and DevelopmentConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501application/pdfhttp://hdl.handle.net/10261/352621reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésThe underlying dataset has been published as supplementary material of the article in the publisher platform at 10.1515/cclm-2023-0326https://doi.org/10.1515/cclm-2023-0326Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3526212026-05-22T06:33:51Z
dc.title.none.fl_str_mv Recommendations for the study of monoclonal gammopathies in the clinical laboratory. A consensus of the Spanish Society of Laboratory Medicine and the Spanish Society of Hematology and Hemotherapy. Part I: Update on laboratory tests for the study of monoclonal gammopathies
title Recommendations for the study of monoclonal gammopathies in the clinical laboratory. A consensus of the Spanish Society of Laboratory Medicine and the Spanish Society of Hematology and Hemotherapy. Part I: Update on laboratory tests for the study of monoclonal gammopathies
spellingShingle Recommendations for the study of monoclonal gammopathies in the clinical laboratory. A consensus of the Spanish Society of Laboratory Medicine and the Spanish Society of Hematology and Hemotherapy. Part I: Update on laboratory tests for the study of monoclonal gammopathies
Cárdenas, María C.
Bone marrow
Electrophoresis
Capillary
Immunofixation
In situ hybridization
Fluorescence
Monoclonal gammopathy of undetermined significance
Multiple myeloma
title_short Recommendations for the study of monoclonal gammopathies in the clinical laboratory. A consensus of the Spanish Society of Laboratory Medicine and the Spanish Society of Hematology and Hemotherapy. Part I: Update on laboratory tests for the study of monoclonal gammopathies
title_full Recommendations for the study of monoclonal gammopathies in the clinical laboratory. A consensus of the Spanish Society of Laboratory Medicine and the Spanish Society of Hematology and Hemotherapy. Part I: Update on laboratory tests for the study of monoclonal gammopathies
title_fullStr Recommendations for the study of monoclonal gammopathies in the clinical laboratory. A consensus of the Spanish Society of Laboratory Medicine and the Spanish Society of Hematology and Hemotherapy. Part I: Update on laboratory tests for the study of monoclonal gammopathies
title_full_unstemmed Recommendations for the study of monoclonal gammopathies in the clinical laboratory. A consensus of the Spanish Society of Laboratory Medicine and the Spanish Society of Hematology and Hemotherapy. Part I: Update on laboratory tests for the study of monoclonal gammopathies
title_sort Recommendations for the study of monoclonal gammopathies in the clinical laboratory. A consensus of the Spanish Society of Laboratory Medicine and the Spanish Society of Hematology and Hemotherapy. Part I: Update on laboratory tests for the study of monoclonal gammopathies
dc.creator.none.fl_str_mv Cárdenas, María C.
García-Sanz, Ramón
Puig, Noemi
Pérez-Surribas, David
Flores-Montero, Juan
Ortiz-Espejo, María
Rubia, Javier de la
Cruz-Iglesias, Elena
author Cárdenas, María C.
author_facet Cárdenas, María C.
García-Sanz, Ramón
Puig, Noemi
Pérez-Surribas, David
Flores-Montero, Juan
Ortiz-Espejo, María
Rubia, Javier de la
Cruz-Iglesias, Elena
author_role author
author2 García-Sanz, Ramón
Puig, Noemi
Pérez-Surribas, David
Flores-Montero, Juan
Ortiz-Espejo, María
Rubia, Javier de la
Cruz-Iglesias, Elena
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Novartis
Gilead Research Scholars
Astellas Pharma
Janssen Research and Development
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Bone marrow
Electrophoresis
Capillary
Immunofixation
In situ hybridization
Fluorescence
Monoclonal gammopathy of undetermined significance
Multiple myeloma
topic Bone marrow
Electrophoresis
Capillary
Immunofixation
In situ hybridization
Fluorescence
Monoclonal gammopathy of undetermined significance
Multiple myeloma
description Monoclonal gammopathies (MG) are characterized by the proliferation of plasma cells that produce identical abnormal immunoglobulins (intact or some of their subunits). This abnormal immunoglobulin component is called monoclonal protein (M-protein), and is considered a biomarker of proliferative activity. The identification, characterization and measurement of M-protein is essential for the management of MG. We conducted a systematic review of the different tests and measurement methods used in the clinical laboratory for the study of M-protein in serum and urine, the biochemistry and hematology tests necessary for clinical evaluation, and studies in bone marrow, peripheral blood and other tissues. This review included literature published between 2009 and 2022. The paper discusses the main methodological characteristics and limitations, as well as the purpose and clinical value of the different tests used in the diagnosis, prognosis, monitoring and assessment of treatment response in MG. Included are methods for the study of M-protein, namely electrophoresis, measurement of immunoglobulin levels, serum free light chains, immunoglobulin heavy chain/light chain pairs, and mass spectrometry, and for the bone marrow examination, morphological analysis, cytogenetics, molecular techniques, and multiparameter flow cytometry.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/352621
url http://hdl.handle.net/10261/352621
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv The underlying dataset has been published as supplementary material of the article in the publisher platform at 10.1515/cclm-2023-0326
https://doi.org/10.1515/cclm-2023-0326
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Walter de Gruyter
publisher.none.fl_str_mv Walter de Gruyter
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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