Sirtuin 1 regulation of developmental genes during differentiation of stem cells

The longevity-promoting NAD+-dependent class III histone deacetylase Sirtuin 1 (SIRT1) is involved in stem cell function by controlling cell fate decision and/or by regulating the p53-dependent expression of NANOG. We show that SIRT1 is down-regulated precisely during human embryonic stem cell diffe...

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Autores: Calvanese, Vincenzo, Lara, Ester, Suárez-Alvarez, Beatriz, Abu Dawud, Raed, Vázquez-Chantada, Mercedes, Martínez Chantar, Maria Luz, Embade, Nieves, López Nieva, Pilar, Horrillo, Angelica, Hmadcha, Abdelkrim, Soria Cubero, Berta, Piazzolla, Daniella, Herranz, Daniela, Serrano Marugán, Manuel, Mato, José M., Andrew, Peter W., López Larrea, Carlos, Esteller, Manel, Fraga, Mario F.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2010
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/179307
Acceso en línea:https://hdl.handle.net/2445/179307
Access Level:acceso abierto
Palabra clave:Diferenciació cel·lular
Cèl·lules mare embrionàries
Expressió gènica
Cell diferentiation
Embryonic stem cells
Gene expression
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spelling Sirtuin 1 regulation of developmental genes during differentiation of stem cellsCalvanese, VincenzoLara, EsterSuárez-Alvarez, BeatrizAbu Dawud, RaedVázquez-Chantada, MercedesMartínez Chantar, Maria LuzEmbade, NievesLópez Nieva, PilarHorrillo, AngelicaHmadcha, AbdelkrimSoria Cubero, BertaPiazzolla, DaniellaHerranz, DanielaSerrano Marugán, ManuelMato, José M.Andrew, Peter W.López Larrea, CarlosEsteller, ManelFraga, Mario F.Diferenciació cel·lularCèl·lules mare embrionàriesExpressió gènicaCell diferentiationEmbryonic stem cellsGene expressionThe longevity-promoting NAD+-dependent class III histone deacetylase Sirtuin 1 (SIRT1) is involved in stem cell function by controlling cell fate decision and/or by regulating the p53-dependent expression of NANOG. We show that SIRT1 is down-regulated precisely during human embryonic stem cell differentiation at both mRNA and protein levels and that the decrease in Sirt1 mRNA is mediated by a molecular pathway that involves the RNA-binding protein HuR and the arginine methyltransferase coactivator-associated arginine methyltransferase 1 (CARM1). SIRT1 down-regulation leads to reactivation of key developmental genes such as the neuroretinal morphogenesis effectors DLL4, TBX3, and PAX6, which are epigenetically repressed by this histone deacetylase in pluripotent human embryonic stem cells. Our results indicate that SIRT1 is regulated during stem cell differentiation in the context of a yet-unknown epigenetic pathway that controls specific developmental genes in embryonic stem cells.National Academy of Sciences2021202120102021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion6 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/179307Articles publicats en revistes (Ciències Fisiològiques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1073/pnas.1001399107Proceedings of the National Academy of Sciences of the United States of America - PNAS, 2010, vol. 107, num. 31, p. 13736-13741https://doi.org/10.1073/pnas.1001399107(c) Calvanese, Vincenzo et al., 2010info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1793072026-05-29T05:05:01Z
dc.title.none.fl_str_mv Sirtuin 1 regulation of developmental genes during differentiation of stem cells
title Sirtuin 1 regulation of developmental genes during differentiation of stem cells
spellingShingle Sirtuin 1 regulation of developmental genes during differentiation of stem cells
Calvanese, Vincenzo
Diferenciació cel·lular
Cèl·lules mare embrionàries
Expressió gènica
Cell diferentiation
Embryonic stem cells
Gene expression
title_short Sirtuin 1 regulation of developmental genes during differentiation of stem cells
title_full Sirtuin 1 regulation of developmental genes during differentiation of stem cells
title_fullStr Sirtuin 1 regulation of developmental genes during differentiation of stem cells
title_full_unstemmed Sirtuin 1 regulation of developmental genes during differentiation of stem cells
title_sort Sirtuin 1 regulation of developmental genes during differentiation of stem cells
dc.creator.none.fl_str_mv Calvanese, Vincenzo
Lara, Ester
Suárez-Alvarez, Beatriz
Abu Dawud, Raed
Vázquez-Chantada, Mercedes
Martínez Chantar, Maria Luz
Embade, Nieves
López Nieva, Pilar
Horrillo, Angelica
Hmadcha, Abdelkrim
Soria Cubero, Berta
Piazzolla, Daniella
Herranz, Daniela
Serrano Marugán, Manuel
Mato, José M.
Andrew, Peter W.
López Larrea, Carlos
Esteller, Manel
Fraga, Mario F.
author Calvanese, Vincenzo
author_facet Calvanese, Vincenzo
Lara, Ester
Suárez-Alvarez, Beatriz
Abu Dawud, Raed
Vázquez-Chantada, Mercedes
Martínez Chantar, Maria Luz
Embade, Nieves
López Nieva, Pilar
Horrillo, Angelica
Hmadcha, Abdelkrim
Soria Cubero, Berta
Piazzolla, Daniella
Herranz, Daniela
Serrano Marugán, Manuel
Mato, José M.
Andrew, Peter W.
López Larrea, Carlos
Esteller, Manel
Fraga, Mario F.
author_role author
author2 Lara, Ester
Suárez-Alvarez, Beatriz
Abu Dawud, Raed
Vázquez-Chantada, Mercedes
Martínez Chantar, Maria Luz
Embade, Nieves
López Nieva, Pilar
Horrillo, Angelica
Hmadcha, Abdelkrim
Soria Cubero, Berta
Piazzolla, Daniella
Herranz, Daniela
Serrano Marugán, Manuel
Mato, José M.
Andrew, Peter W.
López Larrea, Carlos
Esteller, Manel
Fraga, Mario F.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Diferenciació cel·lular
Cèl·lules mare embrionàries
Expressió gènica
Cell diferentiation
Embryonic stem cells
Gene expression
topic Diferenciació cel·lular
Cèl·lules mare embrionàries
Expressió gènica
Cell diferentiation
Embryonic stem cells
Gene expression
description The longevity-promoting NAD+-dependent class III histone deacetylase Sirtuin 1 (SIRT1) is involved in stem cell function by controlling cell fate decision and/or by regulating the p53-dependent expression of NANOG. We show that SIRT1 is down-regulated precisely during human embryonic stem cell differentiation at both mRNA and protein levels and that the decrease in Sirt1 mRNA is mediated by a molecular pathway that involves the RNA-binding protein HuR and the arginine methyltransferase coactivator-associated arginine methyltransferase 1 (CARM1). SIRT1 down-regulation leads to reactivation of key developmental genes such as the neuroretinal morphogenesis effectors DLL4, TBX3, and PAX6, which are epigenetically repressed by this histone deacetylase in pluripotent human embryonic stem cells. Our results indicate that SIRT1 is regulated during stem cell differentiation in the context of a yet-unknown epigenetic pathway that controls specific developmental genes in embryonic stem cells.
publishDate 2010
dc.date.none.fl_str_mv 2010
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/179307
url https://hdl.handle.net/2445/179307
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1073/pnas.1001399107
Proceedings of the National Academy of Sciences of the United States of America - PNAS, 2010, vol. 107, num. 31, p. 13736-13741
https://doi.org/10.1073/pnas.1001399107
dc.rights.none.fl_str_mv (c) Calvanese, Vincenzo et al., 2010
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Calvanese, Vincenzo et al., 2010
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 6 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv National Academy of Sciences
publisher.none.fl_str_mv National Academy of Sciences
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Fisiològiques)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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