Effectiveness and safety of azathioprine for inflammatory pouch disorders: results from the RESERVO study of GETECCU

Background: The usefulness of thiopurines has been poorly explored in pouchitis and other pouch disorders. Objective: To evaluate the effectiveness and safety of azathioprine as maintenance therapy in inflammatory pouch disorders. Design: This was a retrospective and multicentre study. Methods: We i...

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Autores: Mesonero, Francisco, López-García, Alicia, Barreiro de Acosta, Manuel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/68473
Acceso en línea:http://hdl.handle.net/10230/68473
http://dx.doi.org/10.1177/17562848241234476
Access Level:acceso abierto
Palabra clave:Azathioprine
Immunosuppressants
Pouchitis
Thiopurines
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spelling Effectiveness and safety of azathioprine for inflammatory pouch disorders: results from the RESERVO study of GETECCUMesonero, FranciscoLópez-García, AliciaBarreiro de Acosta, ManuelAzathioprineImmunosuppressantsPouchitisThiopurinesBackground: The usefulness of thiopurines has been poorly explored in pouchitis and other pouch disorders. Objective: To evaluate the effectiveness and safety of azathioprine as maintenance therapy in inflammatory pouch disorders. Design: This was a retrospective and multicentre study. Methods: We included patients diagnosed with inflammatory pouch disorders treated with azathioprine in monotherapy. Effectiveness was evaluated at 1 year and in the long term based on normalization of stool frequency, absence of pain, faecal urgency or fistula discharge (clinical remission), or any improvement in these symptoms (clinical response). Endoscopic response was evaluated using the Pouchitis Disease Activity Index (PDAI). Results: In all, 63 patients were included [54% males; median age, 49 (28-77) years]. The therapy was used to treat pouchitis (n = 37) or Crohn's disease of the pouch (n = 26). The rate of clinical response, remission and non-response at 12 months were 52%, 30% and 18%, respectively. After a median follow-up of 23 months (interquartile range 11-55), 19 patients (30%) were in clinical remission, and 45 (66%) stopped therapy. Endoscopic changes were evaluated in 19 cases. PDAI score decreased from 3 (range 2-4) to 1 (range 0-3). In all, 21 patients (33%) presented adverse events and 16 (25%) needed to stop therapy. Conclusion: Azathioprine may be effective in the long term for the treatment of inflammatory pouch disorders and could be included as a therapeutic option.SAGE Publications202420242024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/68473http://dx.doi.org/10.1177/17562848241234476reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésTherap Adv Gastroenterol. 2024 Mar 4;17:17562848241234476© The Author(s), 2024. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).http://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/684732026-05-29T05:05:01Z
dc.title.none.fl_str_mv Effectiveness and safety of azathioprine for inflammatory pouch disorders: results from the RESERVO study of GETECCU
title Effectiveness and safety of azathioprine for inflammatory pouch disorders: results from the RESERVO study of GETECCU
spellingShingle Effectiveness and safety of azathioprine for inflammatory pouch disorders: results from the RESERVO study of GETECCU
Mesonero, Francisco
Azathioprine
Immunosuppressants
Pouchitis
Thiopurines
title_short Effectiveness and safety of azathioprine for inflammatory pouch disorders: results from the RESERVO study of GETECCU
title_full Effectiveness and safety of azathioprine for inflammatory pouch disorders: results from the RESERVO study of GETECCU
title_fullStr Effectiveness and safety of azathioprine for inflammatory pouch disorders: results from the RESERVO study of GETECCU
title_full_unstemmed Effectiveness and safety of azathioprine for inflammatory pouch disorders: results from the RESERVO study of GETECCU
title_sort Effectiveness and safety of azathioprine for inflammatory pouch disorders: results from the RESERVO study of GETECCU
dc.creator.none.fl_str_mv Mesonero, Francisco
López-García, Alicia
Barreiro de Acosta, Manuel
author Mesonero, Francisco
author_facet Mesonero, Francisco
López-García, Alicia
Barreiro de Acosta, Manuel
author_role author
author2 López-García, Alicia
Barreiro de Acosta, Manuel
author2_role author
author
dc.subject.none.fl_str_mv Azathioprine
Immunosuppressants
Pouchitis
Thiopurines
topic Azathioprine
Immunosuppressants
Pouchitis
Thiopurines
description Background: The usefulness of thiopurines has been poorly explored in pouchitis and other pouch disorders. Objective: To evaluate the effectiveness and safety of azathioprine as maintenance therapy in inflammatory pouch disorders. Design: This was a retrospective and multicentre study. Methods: We included patients diagnosed with inflammatory pouch disorders treated with azathioprine in monotherapy. Effectiveness was evaluated at 1 year and in the long term based on normalization of stool frequency, absence of pain, faecal urgency or fistula discharge (clinical remission), or any improvement in these symptoms (clinical response). Endoscopic response was evaluated using the Pouchitis Disease Activity Index (PDAI). Results: In all, 63 patients were included [54% males; median age, 49 (28-77) years]. The therapy was used to treat pouchitis (n = 37) or Crohn's disease of the pouch (n = 26). The rate of clinical response, remission and non-response at 12 months were 52%, 30% and 18%, respectively. After a median follow-up of 23 months (interquartile range 11-55), 19 patients (30%) were in clinical remission, and 45 (66%) stopped therapy. Endoscopic changes were evaluated in 19 cases. PDAI score decreased from 3 (range 2-4) to 1 (range 0-3). In all, 21 patients (33%) presented adverse events and 16 (25%) needed to stop therapy. Conclusion: Azathioprine may be effective in the long term for the treatment of inflammatory pouch disorders and could be included as a therapeutic option.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/68473
http://dx.doi.org/10.1177/17562848241234476
url http://hdl.handle.net/10230/68473
http://dx.doi.org/10.1177/17562848241234476
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Therap Adv Gastroenterol. 2024 Mar 4;17:17562848241234476
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by-nc/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv SAGE Publications
publisher.none.fl_str_mv SAGE Publications
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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