Uniparental markers in Italy reveal a sex-biased genetic structure and different historical strata
Located in the center of the Mediterranean landscape and with an extensive coastal line, the territory of what is today Italy has played an important role in the history of human settlements and movements of Southern Europe and the Mediterranean Basin. Populated since Paleolithic times, the complexi...
| Autores: | , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2013 |
| País: | España |
| Institución: | Universitat Pompeu Fabra |
| Repositorio: | Repositorio Digital de la UPF |
| OAI Identifier: | oai:repositori.upf.edu:10230/23569 |
| Acceso en línea: | http://hdl.handle.net/10230/23569 http://dx.doi.org/10.1371/journal.pone.0065441 |
| Access Level: | acceso abierto |
| Palabra clave: | ADN mitocondrial -- Genètica Cromosoma Y |
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Uniparental markers in Italy reveal a sex-biased genetic structure and different historical strataBoattini, AlessioMartínez Cruz, BegoñaSarno, StefaniaHarmant, ChristineUseli, AntonellaSanz, PaulaYang-Yao, DanieleManry, JeremyCiani, GraziellaLuiselli, DonataQuintana Murci, LluisComas, David, 1969-Pettener, DavideGenographic ConsortiumADN mitocondrial -- GenèticaCromosoma YLocated in the center of the Mediterranean landscape and with an extensive coastal line, the territory of what is today Italy has played an important role in the history of human settlements and movements of Southern Europe and the Mediterranean Basin. Populated since Paleolithic times, the complexity of human movements during the Neolithic, the Metal Ages and the most recent history of the two last millennia (involving the overlapping of different cultural and demic strata) has shaped the pattern of the modern Italian genetic structure. With the aim of disentangling this pattern and understanding which processes more importantly shaped the distribution of diversity, we have analyzed the uniparentally-inherited markers in 900 individuals from an extensive sampling across the Italian peninsula, Sardinia and Sicily. Spatial PCAs and DAPCs revealed a sex-biased pattern indicating different demographic histories for males and females. Besides the genetic outlier position of Sardinians, a North West–South East Y-chromosome structure is found in continental Italy. Such structure is in agreement with recent archeological syntheses indicating two independent and parallel processes of Neolithisation. In addition, date estimates pinpoint the importance of the cultural and demographic events during the late Neolithic and Metal Ages. On the other hand, mitochondrial diversity is distributed more homogeneously in agreement with older population events that might be related to the presence of an Italian Refugium during the last glacial period in EuropeThis study was supported by Strategic Project 2006-09 from the University of Bologna to DP and from MIUR PRIN 2007 and 2009 Grants to DP. The project was also supported by the Spanish Government grant CGL2010-14944/BOSPublic Library of Science (PLoS)201520152013info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/23569http://dx.doi.org/10.1371/journal.pone.0065441reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésPLoS ONE. 2013;8(5):e65441info:eu-repo/grantAgreement/ES/3PN/CGL2010-14944© 2013 Boattini et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are creditedhttps://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/235692026-06-12T07:21:37Z |
| dc.title.none.fl_str_mv |
Uniparental markers in Italy reveal a sex-biased genetic structure and different historical strata |
| title |
Uniparental markers in Italy reveal a sex-biased genetic structure and different historical strata |
| spellingShingle |
Uniparental markers in Italy reveal a sex-biased genetic structure and different historical strata Boattini, Alessio ADN mitocondrial -- Genètica Cromosoma Y |
| title_short |
Uniparental markers in Italy reveal a sex-biased genetic structure and different historical strata |
| title_full |
Uniparental markers in Italy reveal a sex-biased genetic structure and different historical strata |
| title_fullStr |
Uniparental markers in Italy reveal a sex-biased genetic structure and different historical strata |
| title_full_unstemmed |
Uniparental markers in Italy reveal a sex-biased genetic structure and different historical strata |
| title_sort |
Uniparental markers in Italy reveal a sex-biased genetic structure and different historical strata |
| dc.creator.none.fl_str_mv |
Boattini, Alessio Martínez Cruz, Begoña Sarno, Stefania Harmant, Christine Useli, Antonella Sanz, Paula Yang-Yao, Daniele Manry, Jeremy Ciani, Graziella Luiselli, Donata Quintana Murci, Lluis Comas, David, 1969- Pettener, Davide Genographic Consortium |
| author |
Boattini, Alessio |
| author_facet |
Boattini, Alessio Martínez Cruz, Begoña Sarno, Stefania Harmant, Christine Useli, Antonella Sanz, Paula Yang-Yao, Daniele Manry, Jeremy Ciani, Graziella Luiselli, Donata Quintana Murci, Lluis Comas, David, 1969- Pettener, Davide Genographic Consortium |
| author_role |
author |
| author2 |
Martínez Cruz, Begoña Sarno, Stefania Harmant, Christine Useli, Antonella Sanz, Paula Yang-Yao, Daniele Manry, Jeremy Ciani, Graziella Luiselli, Donata Quintana Murci, Lluis Comas, David, 1969- Pettener, Davide Genographic Consortium |
| author2_role |
author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
ADN mitocondrial -- Genètica Cromosoma Y |
| topic |
ADN mitocondrial -- Genètica Cromosoma Y |
| description |
Located in the center of the Mediterranean landscape and with an extensive coastal line, the territory of what is today Italy has played an important role in the history of human settlements and movements of Southern Europe and the Mediterranean Basin. Populated since Paleolithic times, the complexity of human movements during the Neolithic, the Metal Ages and the most recent history of the two last millennia (involving the overlapping of different cultural and demic strata) has shaped the pattern of the modern Italian genetic structure. With the aim of disentangling this pattern and understanding which processes more importantly shaped the distribution of diversity, we have analyzed the uniparentally-inherited markers in 900 individuals from an extensive sampling across the Italian peninsula, Sardinia and Sicily. Spatial PCAs and DAPCs revealed a sex-biased pattern indicating different demographic histories for males and females. Besides the genetic outlier position of Sardinians, a North West–South East Y-chromosome structure is found in continental Italy. Such structure is in agreement with recent archeological syntheses indicating two independent and parallel processes of Neolithisation. In addition, date estimates pinpoint the importance of the cultural and demographic events during the late Neolithic and Metal Ages. On the other hand, mitochondrial diversity is distributed more homogeneously in agreement with older population events that might be related to the presence of an Italian Refugium during the last glacial period in Europe |
| publishDate |
2013 |
| dc.date.none.fl_str_mv |
2013 2015 2015 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10230/23569 http://dx.doi.org/10.1371/journal.pone.0065441 |
| url |
http://hdl.handle.net/10230/23569 http://dx.doi.org/10.1371/journal.pone.0065441 |
| dc.language.none.fl_str_mv |
Inglés |
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Inglés |
| dc.relation.none.fl_str_mv |
PLoS ONE. 2013;8(5):e65441 info:eu-repo/grantAgreement/ES/3PN/CGL2010-14944 |
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https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
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https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf application/pdf |
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Public Library of Science (PLoS) |
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Public Library of Science (PLoS) |
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reponame:Repositorio Digital de la UPF instname:Universitat Pompeu Fabra |
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Universitat Pompeu Fabra |
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Repositorio Digital de la UPF |
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Repositorio Digital de la UPF |
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15.811543 |