Seasonal variations in the onset of positive and negative renal ANCA-associated vasculitis in Spain

Background: The closure of long-standing gaps in our knowledge of aetiological factors behind anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a major challenge. Descriptive and analytical epidemiological studies can improve our understanding of environmental influences. Re...

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Autores: Bordignon Draibe, Juliana, Rodó López, Xavier, Fulladosa, Xavier, Martinez Valenzuela, Laura, Diaz Encarnación, Montserrat, Santos, Lara, Marco, Helena, Quintana Porras, Luis F., Rodriguez, Eva, Barros Freiría, Xoana, Garcia, Rosa, Balius, Anna, Cruzado, Josep Ma., Torras Ambròs, Joan, Malalties Glomerulars de la Societat Catalana de Nefrologia (GLOMCAT)
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Recursos:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/122190
Acesso em linha:https://hdl.handle.net/2445/122190
Access Level:acceso abierto
Palavra-chave:Vasculitis
Epidemiologia
Epidemiology
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spelling Seasonal variations in the onset of positive and negative renal ANCA-associated vasculitis in SpainBordignon Draibe, JulianaRodó López, XavierFulladosa, XavierMartinez Valenzuela, LauraDiaz Encarnación, MontserratSantos, LaraMarco, HelenaQuintana Porras, Luis F.Rodriguez, EvaBarros Freiría, XoanaGarcia, RosaBalius, AnnaCruzado, Josep Ma.Torras Ambròs, JoanMalalties Glomerulars de la Societat Catalana de Nefrologia (GLOMCAT)VasculitisEpidemiologiaVasculitisEpidemiologyBackground: The closure of long-standing gaps in our knowledge of aetiological factors behind anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a major challenge. Descriptive and analytical epidemiological studies can improve our understanding of environmental influences. Reported seasonal variations in AAV, mainly related to Wegener's disease, have shown an increasing number of cases in the winter months, which could be related to an extrinsic factor underlying infection. The objective of this paper was to study seasonal variations in AAV with respect to renal affectation diagnosed in Catalonia, Spain. Methods: Two hundred and thirty-four patients diagnosed for renal AAV between 2001 and 2014 in eight hospitals in Catalonia were included in the study. We used medical records to retrospectively analyse the date of the first symptoms attributed to the AAV, ANCA subtypes, the degree of renal impairment and renal histology. Results: Of the 234 patients studied, 49.2% were male and 50.8% female. For ANCA status, 8.5% were positive, 15.9% were proteinase-3-positive and 75.6% were myeloperoxidase-positive. In relation to histological classification, 17.8% were sclerotic, 11.7% focal, 38.8% crescentic and 31.7% mixed. Regarding seasonal distribution, we observed a clear seasonal periodicity with a significantly higher incidence of cases in the winter. Applying an Eigen decomposition, we observed a periodic fluctuation of frequencies around the annual cycle with peaks every 10–12 months, and higher incidence of AAV cases in February. Conclusions: Our results confirm, in Catalonia, the seasonal periodicity of AAV with a higher incidence in the winter, as formerly described in the literature for other regions. An environmental factor, likely one that is infectious, may explain this finding.Oxford University Press2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/122190Articles publicats en revistes (ISGlobal)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: http://dx.doi.org/10.1093/ckj/sfx127Clinical Kidney Journal, 2017http://dx.doi.org/10.1093/ckj/sfx127cc by-nc (c) Draibe et al., 2017http://creativecommons.org/licenses/by-nc/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1221902026-05-27T06:46:51Z
dc.title.none.fl_str_mv Seasonal variations in the onset of positive and negative renal ANCA-associated vasculitis in Spain
title Seasonal variations in the onset of positive and negative renal ANCA-associated vasculitis in Spain
spellingShingle Seasonal variations in the onset of positive and negative renal ANCA-associated vasculitis in Spain
Bordignon Draibe, Juliana
Vasculitis
Epidemiologia
Vasculitis
Epidemiology
title_short Seasonal variations in the onset of positive and negative renal ANCA-associated vasculitis in Spain
title_full Seasonal variations in the onset of positive and negative renal ANCA-associated vasculitis in Spain
title_fullStr Seasonal variations in the onset of positive and negative renal ANCA-associated vasculitis in Spain
title_full_unstemmed Seasonal variations in the onset of positive and negative renal ANCA-associated vasculitis in Spain
title_sort Seasonal variations in the onset of positive and negative renal ANCA-associated vasculitis in Spain
dc.creator.none.fl_str_mv Bordignon Draibe, Juliana
Rodó López, Xavier
Fulladosa, Xavier
Martinez Valenzuela, Laura
Diaz Encarnación, Montserrat
Santos, Lara
Marco, Helena
Quintana Porras, Luis F.
Rodriguez, Eva
Barros Freiría, Xoana
Garcia, Rosa
Balius, Anna
Cruzado, Josep Ma.
Torras Ambròs, Joan
Malalties Glomerulars de la Societat Catalana de Nefrologia (GLOMCAT)
author Bordignon Draibe, Juliana
author_facet Bordignon Draibe, Juliana
Rodó López, Xavier
Fulladosa, Xavier
Martinez Valenzuela, Laura
Diaz Encarnación, Montserrat
Santos, Lara
Marco, Helena
Quintana Porras, Luis F.
Rodriguez, Eva
Barros Freiría, Xoana
Garcia, Rosa
Balius, Anna
Cruzado, Josep Ma.
Torras Ambròs, Joan
Malalties Glomerulars de la Societat Catalana de Nefrologia (GLOMCAT)
author_role author
author2 Rodó López, Xavier
Fulladosa, Xavier
Martinez Valenzuela, Laura
Diaz Encarnación, Montserrat
Santos, Lara
Marco, Helena
Quintana Porras, Luis F.
Rodriguez, Eva
Barros Freiría, Xoana
Garcia, Rosa
Balius, Anna
Cruzado, Josep Ma.
Torras Ambròs, Joan
Malalties Glomerulars de la Societat Catalana de Nefrologia (GLOMCAT)
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Vasculitis
Epidemiologia
Vasculitis
Epidemiology
topic Vasculitis
Epidemiologia
Vasculitis
Epidemiology
description Background: The closure of long-standing gaps in our knowledge of aetiological factors behind anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a major challenge. Descriptive and analytical epidemiological studies can improve our understanding of environmental influences. Reported seasonal variations in AAV, mainly related to Wegener's disease, have shown an increasing number of cases in the winter months, which could be related to an extrinsic factor underlying infection. The objective of this paper was to study seasonal variations in AAV with respect to renal affectation diagnosed in Catalonia, Spain. Methods: Two hundred and thirty-four patients diagnosed for renal AAV between 2001 and 2014 in eight hospitals in Catalonia were included in the study. We used medical records to retrospectively analyse the date of the first symptoms attributed to the AAV, ANCA subtypes, the degree of renal impairment and renal histology. Results: Of the 234 patients studied, 49.2% were male and 50.8% female. For ANCA status, 8.5% were positive, 15.9% were proteinase-3-positive and 75.6% were myeloperoxidase-positive. In relation to histological classification, 17.8% were sclerotic, 11.7% focal, 38.8% crescentic and 31.7% mixed. Regarding seasonal distribution, we observed a clear seasonal periodicity with a significantly higher incidence of cases in the winter. Applying an Eigen decomposition, we observed a periodic fluctuation of frequencies around the annual cycle with peaks every 10–12 months, and higher incidence of AAV cases in February. Conclusions: Our results confirm, in Catalonia, the seasonal periodicity of AAV with a higher incidence in the winter, as formerly described in the literature for other regions. An environmental factor, likely one that is infectious, may explain this finding.
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/122190
url https://hdl.handle.net/2445/122190
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://dx.doi.org/10.1093/ckj/sfx127
Clinical Kidney Journal, 2017
http://dx.doi.org/10.1093/ckj/sfx127
dc.rights.none.fl_str_mv cc by-nc (c) Draibe et al., 2017
http://creativecommons.org/licenses/by-nc/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by-nc (c) Draibe et al., 2017
http://creativecommons.org/licenses/by-nc/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv Articles publicats en revistes (ISGlobal)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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