Salivary immunity and lower respiratory tract infections in non-elite marathon runners
Respiratory infections are common after strenuous exercise, when salivary immunity may be altered. We aim to investigate changes in salivary immunity after a marathon and its relationship with lower respiratory tract infections (LRTI) in healthy non-elite marathon runners. Forty seven healthy marath...
| Autores: | , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2018 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:253727 |
| Acceso en línea: | https://ddd.uab.cat/record/253727 https://dx.doi.org/urn:doi:10.1371/journal.pone.0206059 |
| Access Level: | acceso abierto |
| id |
ES_3ccc3a3ffca312fb80b4b6c45e982cb0 |
|---|---|
| oai_identifier_str |
oai:ddd.uab.cat:253727 |
| network_acronym_str |
ES |
| network_name_str |
España |
| repository_id_str |
|
| spelling |
Salivary immunity and lower respiratory tract infections in non-elite marathon runnersCantó, Elisabet|||0000-0002-1782-1855Roca, Emma|||0000-0002-2338-5877Perea, Lidia|||0000-0002-1624-0012Rodrigo-Troyano, AnaSuarez-Cuartin, Guillermo|||0000-0003-2320-6047Giner, Jordi|||0000-0002-3044-2059Feliu Ribera, Anna|||0000-0003-2074-2231Soria Fernández, José Manuel|||0000-0002-6226-4293Nescolarde, Lexa|||0000-0001-6861-5106Vidal, Silvia|||0000-0002-3909-6682Sibila, Oriol|||0000-0002-4833-6713Respiratory infections are common after strenuous exercise, when salivary immunity may be altered. We aim to investigate changes in salivary immunity after a marathon and its relationship with lower respiratory tract infections (LRTI) in healthy non-elite marathon runners. Forty seven healthy marathon runners (28 males and 19 females) who completed the 42.195 km of the 2016 Barcelona marathon were studied. Saliva and blood samples were collected the day before the marathon and two days after the end of the race. Salivary IgA, antimicrobial proteins (lactoferrin, lysozyme) and chemokines (Groα, Groβ, MCP-1) were determined using ELISA kits in saliva supernatant. Blood biochemistry and haemogram were analyzed in all participants. The presence of LRTI was considered in those runners who reported infectious lower respiratory tract symptoms during a minimum of 3 consecutive days in the 2 weeks after the race. Eight participants (17%) presented a LRTI during the 2 weeks of follow-up. Higher lysozyme levels were detected after the race in runners with LRTI when compared with those without infection. A decrease in salivary lysozyme, Groα and Groβ levels after the race were observed in those runners who did not develop a LRTI when compared to basal levels. Salivary Groα levels correlated with basophil blood counts, and salivary lysozyme levels correlated with leukocyte blood counts. LRTI are common after a marathon race in non-elite healthy runners. Changes in salivary antimicrobial proteins and chemokines are related to the presence of LRTI and correlate with systemic defense cells, which suggest an important role of salivary immunity in the development of LRTI in non-elite marathon runners.Universitat Autònoma de Barcelona 22018-01-0120182018-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/253727https://dx.doi.org/urn:doi:10.1371/journal.pone.0206059reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2537272026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Salivary immunity and lower respiratory tract infections in non-elite marathon runners |
| title |
Salivary immunity and lower respiratory tract infections in non-elite marathon runners |
| spellingShingle |
Salivary immunity and lower respiratory tract infections in non-elite marathon runners Cantó, Elisabet|||0000-0002-1782-1855 |
| title_short |
Salivary immunity and lower respiratory tract infections in non-elite marathon runners |
| title_full |
Salivary immunity and lower respiratory tract infections in non-elite marathon runners |
| title_fullStr |
Salivary immunity and lower respiratory tract infections in non-elite marathon runners |
| title_full_unstemmed |
Salivary immunity and lower respiratory tract infections in non-elite marathon runners |
| title_sort |
Salivary immunity and lower respiratory tract infections in non-elite marathon runners |
| dc.creator.none.fl_str_mv |
Cantó, Elisabet|||0000-0002-1782-1855 Roca, Emma|||0000-0002-2338-5877 Perea, Lidia|||0000-0002-1624-0012 Rodrigo-Troyano, Ana Suarez-Cuartin, Guillermo|||0000-0003-2320-6047 Giner, Jordi|||0000-0002-3044-2059 Feliu Ribera, Anna|||0000-0003-2074-2231 Soria Fernández, José Manuel|||0000-0002-6226-4293 Nescolarde, Lexa|||0000-0001-6861-5106 Vidal, Silvia|||0000-0002-3909-6682 Sibila, Oriol|||0000-0002-4833-6713 |
| author |
Cantó, Elisabet|||0000-0002-1782-1855 |
| author_facet |
Cantó, Elisabet|||0000-0002-1782-1855 Roca, Emma|||0000-0002-2338-5877 Perea, Lidia|||0000-0002-1624-0012 Rodrigo-Troyano, Ana Suarez-Cuartin, Guillermo|||0000-0003-2320-6047 Giner, Jordi|||0000-0002-3044-2059 Feliu Ribera, Anna|||0000-0003-2074-2231 Soria Fernández, José Manuel|||0000-0002-6226-4293 Nescolarde, Lexa|||0000-0001-6861-5106 Vidal, Silvia|||0000-0002-3909-6682 Sibila, Oriol|||0000-0002-4833-6713 |
| author_role |
author |
| author2 |
Roca, Emma|||0000-0002-2338-5877 Perea, Lidia|||0000-0002-1624-0012 Rodrigo-Troyano, Ana Suarez-Cuartin, Guillermo|||0000-0003-2320-6047 Giner, Jordi|||0000-0002-3044-2059 Feliu Ribera, Anna|||0000-0003-2074-2231 Soria Fernández, José Manuel|||0000-0002-6226-4293 Nescolarde, Lexa|||0000-0001-6861-5106 Vidal, Silvia|||0000-0002-3909-6682 Sibila, Oriol|||0000-0002-4833-6713 |
| author2_role |
author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universitat Autònoma de Barcelona |
| description |
Respiratory infections are common after strenuous exercise, when salivary immunity may be altered. We aim to investigate changes in salivary immunity after a marathon and its relationship with lower respiratory tract infections (LRTI) in healthy non-elite marathon runners. Forty seven healthy marathon runners (28 males and 19 females) who completed the 42.195 km of the 2016 Barcelona marathon were studied. Saliva and blood samples were collected the day before the marathon and two days after the end of the race. Salivary IgA, antimicrobial proteins (lactoferrin, lysozyme) and chemokines (Groα, Groβ, MCP-1) were determined using ELISA kits in saliva supernatant. Blood biochemistry and haemogram were analyzed in all participants. The presence of LRTI was considered in those runners who reported infectious lower respiratory tract symptoms during a minimum of 3 consecutive days in the 2 weeks after the race. Eight participants (17%) presented a LRTI during the 2 weeks of follow-up. Higher lysozyme levels were detected after the race in runners with LRTI when compared with those without infection. A decrease in salivary lysozyme, Groα and Groβ levels after the race were observed in those runners who did not develop a LRTI when compared to basal levels. Salivary Groα levels correlated with basophil blood counts, and salivary lysozyme levels correlated with leukocyte blood counts. LRTI are common after a marathon race in non-elite healthy runners. Changes in salivary antimicrobial proteins and chemokines are related to the presence of LRTI and correlate with systemic defense cells, which suggest an important role of salivary immunity in the development of LRTI in non-elite marathon runners. |
| publishDate |
2018 |
| dc.date.none.fl_str_mv |
2 2018-01-01 2018 2018-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/253727 https://dx.doi.org/urn:doi:10.1371/journal.pone.0206059 |
| url |
https://ddd.uab.cat/record/253727 https://dx.doi.org/urn:doi:10.1371/journal.pone.0206059 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.source.none.fl_str_mv |
reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
| instname_str |
Universitat Autònoma de Barcelona |
| reponame_str |
Dipòsit Digital de Documents de la UAB |
| collection |
Dipòsit Digital de Documents de la UAB |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1869406399096684544 |
| score |
15,300719 |