Nucleus accumbens is involved in human action monitoring: evidence from invasive electrophysiological recordings

The Nucleus accumbens (Nacc) has been proposed to act as a limbic-motor interface. Here, using invasive intraoperative recordings in an awake patient suffering from obsessive-compulsive disease (OCD), we demonstrate that its activity is modulated by the quality of performance of the subject in a cho...

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Autores: Münte, Thomas F., Heldmann, Marcus, Hinrichs, Hermann, Marco Pallarés, Josep, Krämer, Ulrike M., Sturm, Volker, Heinze, Hans-Jochen
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2008
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/65281
Acceso en línea:https://hdl.handle.net/2445/65281
Access Level:acceso abierto
Palabra clave:Potencials evocats (Electrofisiologia)
Neurocirurgia
Conducta (Psicologia)
Evoked potentials (Electrophysiology)
Neurosurgery
Human behavior
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spelling Nucleus accumbens is involved in human action monitoring: evidence from invasive electrophysiological recordingsMünte, Thomas F.Heldmann, MarcusHinrichs, HermannMarco Pallarés, JosepKrämer, Ulrike M.Sturm, VolkerHeinze, Hans-JochenPotencials evocats (Electrofisiologia)NeurocirurgiaConducta (Psicologia)Evoked potentials (Electrophysiology)NeurosurgeryHuman behaviorThe Nucleus accumbens (Nacc) has been proposed to act as a limbic-motor interface. Here, using invasive intraoperative recordings in an awake patient suffering from obsessive-compulsive disease (OCD), we demonstrate that its activity is modulated by the quality of performance of the subject in a choice reaction time task designed to tap action monitoring processes. Action monitoring, that is, error detection and correction, is thought to be supported by a system involving the dopaminergic midbrain, the basal ganglia, and the medial prefrontal cortex. In surface electrophysiological recordings, action monitoring is indexed by an error-related negativity (ERN) appearing time-locked to the erroneous responses and emanating from the medial frontal cortex. In preoperative scalp recordings the patient's ERN was found to be signifi cantly increased compared to a large (n = 83) normal sample, suggesting enhanced action monitoring processes. Intraoperatively, error-related modulations were obtained from the Nacc but not from a site 5 mm above. Importantly, crosscorrelation analysis showed that error-related activity in the Nacc preceded surface activity by 40 ms. We propose that the Nacc is involved in action monitoring, possibly by using error signals from the dopaminergic midbrain to adjust the relative impact of limbic and prefrontal inputs on frontal control systems in order to optimize goal-directed behavior.Frontiers Media2008info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/65281Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: http://dx.doi.org/10.3389/neuro.09.011.2007Frontiers in Human Neuroscience, 2008, vol. 1, p. 1-6http://dx.doi.org/10.3389/neuro.09.011.2007cc-by (c) Münte, T.F. et al., 2008http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/652812026-05-27T06:46:51Z
dc.title.none.fl_str_mv Nucleus accumbens is involved in human action monitoring: evidence from invasive electrophysiological recordings
title Nucleus accumbens is involved in human action monitoring: evidence from invasive electrophysiological recordings
spellingShingle Nucleus accumbens is involved in human action monitoring: evidence from invasive electrophysiological recordings
Münte, Thomas F.
Potencials evocats (Electrofisiologia)
Neurocirurgia
Conducta (Psicologia)
Evoked potentials (Electrophysiology)
Neurosurgery
Human behavior
title_short Nucleus accumbens is involved in human action monitoring: evidence from invasive electrophysiological recordings
title_full Nucleus accumbens is involved in human action monitoring: evidence from invasive electrophysiological recordings
title_fullStr Nucleus accumbens is involved in human action monitoring: evidence from invasive electrophysiological recordings
title_full_unstemmed Nucleus accumbens is involved in human action monitoring: evidence from invasive electrophysiological recordings
title_sort Nucleus accumbens is involved in human action monitoring: evidence from invasive electrophysiological recordings
dc.creator.none.fl_str_mv Münte, Thomas F.
Heldmann, Marcus
Hinrichs, Hermann
Marco Pallarés, Josep
Krämer, Ulrike M.
Sturm, Volker
Heinze, Hans-Jochen
author Münte, Thomas F.
author_facet Münte, Thomas F.
Heldmann, Marcus
Hinrichs, Hermann
Marco Pallarés, Josep
Krämer, Ulrike M.
Sturm, Volker
Heinze, Hans-Jochen
author_role author
author2 Heldmann, Marcus
Hinrichs, Hermann
Marco Pallarés, Josep
Krämer, Ulrike M.
Sturm, Volker
Heinze, Hans-Jochen
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Potencials evocats (Electrofisiologia)
Neurocirurgia
Conducta (Psicologia)
Evoked potentials (Electrophysiology)
Neurosurgery
Human behavior
topic Potencials evocats (Electrofisiologia)
Neurocirurgia
Conducta (Psicologia)
Evoked potentials (Electrophysiology)
Neurosurgery
Human behavior
description The Nucleus accumbens (Nacc) has been proposed to act as a limbic-motor interface. Here, using invasive intraoperative recordings in an awake patient suffering from obsessive-compulsive disease (OCD), we demonstrate that its activity is modulated by the quality of performance of the subject in a choice reaction time task designed to tap action monitoring processes. Action monitoring, that is, error detection and correction, is thought to be supported by a system involving the dopaminergic midbrain, the basal ganglia, and the medial prefrontal cortex. In surface electrophysiological recordings, action monitoring is indexed by an error-related negativity (ERN) appearing time-locked to the erroneous responses and emanating from the medial frontal cortex. In preoperative scalp recordings the patient's ERN was found to be signifi cantly increased compared to a large (n = 83) normal sample, suggesting enhanced action monitoring processes. Intraoperatively, error-related modulations were obtained from the Nacc but not from a site 5 mm above. Importantly, crosscorrelation analysis showed that error-related activity in the Nacc preceded surface activity by 40 ms. We propose that the Nacc is involved in action monitoring, possibly by using error signals from the dopaminergic midbrain to adjust the relative impact of limbic and prefrontal inputs on frontal control systems in order to optimize goal-directed behavior.
publishDate 2008
dc.date.none.fl_str_mv 2008
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/65281
url https://hdl.handle.net/2445/65281
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://dx.doi.org/10.3389/neuro.09.011.2007
Frontiers in Human Neuroscience, 2008, vol. 1, p. 1-6
http://dx.doi.org/10.3389/neuro.09.011.2007
dc.rights.none.fl_str_mv cc-by (c) Münte, T.F. et al., 2008
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Münte, T.F. et al., 2008
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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