Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways
Background Inhibitory control (IC) is critical to keep long-term goals in everyday life. Bidirectional relationships between IC deficits and obesity are behind unhealthy eating and physical exercise habits. Methods We studied gut microbiome composition and functionality, and plasma and faecal metabo...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universitat de Lleida (UdL) |
| Repositorio: | Repositori Obert UdL |
| OAI Identifier: | oai:repositori.udl.cat:10459.1/71488 |
| Acceso en línea: | https://doi.org/10.1136/gutjnl-2020-323371 http://hdl.handle.net/10459.1/71488 |
| Access Level: | acceso abierto |
| Palabra clave: | Intestinal microbiology Obesity |
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España |
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| dc.title.none.fl_str_mv |
Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways |
| title |
Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways |
| spellingShingle |
Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways Arnoriaga Rodríguez, María Intestinal microbiology Obesity |
| title_short |
Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways |
| title_full |
Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways |
| title_fullStr |
Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways |
| title_full_unstemmed |
Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways |
| title_sort |
Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways |
| dc.creator.none.fl_str_mv |
Arnoriaga Rodríguez, María Mayneris Perxachs, Jordi Contreras-Rodríguez, Oren Burokas, Aurelijus Ortega Sánchez, Juan Antonio Blasco Solà, Gerard Coll, Claudia Biarnés, Carles Castells Nobau, Anna Puig, Josep Garre Olmo, Josep Ramos, Rafel Pedraza, Salvador Brugada, Ramon Vilanova, Joan Carles Serena, Joaquín Barretina Ginesta, Jordi Gich Fullà, Jordi Pérez Brocal, Vicente Moya, Andrés Fernández Real, Xavier Ramió Torrentà, Lluís Pamplona Gras, Reinald Sol, Joaquim Jové Font, Mariona Ricart, Wifredo Portero Otín, Manuel Maldonado, Rafael Fernández Real, José Manuel |
| author |
Arnoriaga Rodríguez, María |
| author_facet |
Arnoriaga Rodríguez, María Mayneris Perxachs, Jordi Contreras-Rodríguez, Oren Burokas, Aurelijus Ortega Sánchez, Juan Antonio Blasco Solà, Gerard Coll, Claudia Biarnés, Carles Castells Nobau, Anna Puig, Josep Garre Olmo, Josep Ramos, Rafel Pedraza, Salvador Brugada, Ramon Vilanova, Joan Carles Serena, Joaquín Barretina Ginesta, Jordi Gich Fullà, Jordi Pérez Brocal, Vicente Moya, Andrés Fernández Real, Xavier Ramió Torrentà, Lluís Pamplona Gras, Reinald Sol, Joaquim Jové Font, Mariona Ricart, Wifredo Portero Otín, Manuel Maldonado, Rafael Fernández Real, José Manuel |
| author_role |
author |
| author2 |
Mayneris Perxachs, Jordi Contreras-Rodríguez, Oren Burokas, Aurelijus Ortega Sánchez, Juan Antonio Blasco Solà, Gerard Coll, Claudia Biarnés, Carles Castells Nobau, Anna Puig, Josep Garre Olmo, Josep Ramos, Rafel Pedraza, Salvador Brugada, Ramon Vilanova, Joan Carles Serena, Joaquín Barretina Ginesta, Jordi Gich Fullà, Jordi Pérez Brocal, Vicente Moya, Andrés Fernández Real, Xavier Ramió Torrentà, Lluís Pamplona Gras, Reinald Sol, Joaquim Jové Font, Mariona Ricart, Wifredo Portero Otín, Manuel Maldonado, Rafael Fernández Real, José Manuel |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Intestinal microbiology Obesity |
| topic |
Intestinal microbiology Obesity |
| description |
Background Inhibitory control (IC) is critical to keep long-term goals in everyday life. Bidirectional relationships between IC deficits and obesity are behind unhealthy eating and physical exercise habits. Methods We studied gut microbiome composition and functionality, and plasma and faecal metabolomics in association with cognitive tests evaluating inhibitory control (Stroop test) and brain structure in a discovery (n=156), both cross-sectionally and longitudinally, and in an independent replication cohort (n=970). Faecal microbiota transplantation (FMT) in mice evaluated the impact on reversal learning and medial prefrontal cortex (mPFC) transcriptomics. Results An interplay among IC, brain structure (in humans) and mPFC transcriptomics (in mice), plasma/faecal metabolomics and the gut metagenome was found. Obesity-dependent alterations in one-carbon metabolism, tryptophan and histidine pathways were associated with IC in the two independent cohorts. Bacterial functions linked to one-carbon metabolism (thyX,dut, exodeoxyribonuclease V), and the anterior cingulate cortex volume were associated with IC, cross-sectionally and longitudinally. FMT from individuals with obesity led to alterations in mice reversal learning. In an independent FMT experiment, human donor’s bacterial functions related to IC deficits were associated with mPFC expression of one-carbon metabolism-related genes of recipient’s mice. Conclusion These results highlight the importance of targeting obesity-related impulsive behaviour through the induction of gut microbiota shifts. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://doi.org/10.1136/gutjnl-2020-323371 http://hdl.handle.net/10459.1/71488 |
| url |
https://doi.org/10.1136/gutjnl-2020-323371 http://hdl.handle.net/10459.1/71488 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
info:eu-repo/grantAgreement/MINECO//SAF2015-65878-R info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2017-84060-R Reproducció del document publicat a: http://doi.org/10.1136/gutjnl-2020-323371 Gut, 2021, vol. 0, p. 1-14 info:eu-repo/grantAgreement/EC/FP7/602891 |
| dc.rights.none.fl_str_mv |
cc-by-nc, (c) Armoriaga et al., 2021 info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc/4.0/ |
| rights_invalid_str_mv |
cc-by-nc, (c) Armoriaga et al., 2021 http://creativecommons.org/licenses/by-nc/4.0/ |
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openAccess |
| dc.publisher.none.fl_str_mv |
BMJ Publishing Group British Society of Gastroenterology |
| publisher.none.fl_str_mv |
BMJ Publishing Group British Society of Gastroenterology |
| dc.source.none.fl_str_mv |
reponame:Repositori Obert UdL instname:Universitat de Lleida (UdL) |
| instname_str |
Universitat de Lleida (UdL) |
| reponame_str |
Repositori Obert UdL |
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Repositori Obert UdL |
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|
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|
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1869406392879677440 |
| spelling |
Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathwaysArnoriaga Rodríguez, MaríaMayneris Perxachs, JordiContreras-Rodríguez, OrenBurokas, AurelijusOrtega Sánchez, Juan AntonioBlasco Solà, GerardColl, ClaudiaBiarnés, CarlesCastells Nobau, AnnaPuig, JosepGarre Olmo, JosepRamos, RafelPedraza, SalvadorBrugada, RamonVilanova, Joan CarlesSerena, JoaquínBarretina Ginesta, JordiGich Fullà, JordiPérez Brocal, VicenteMoya, AndrésFernández Real, XavierRamió Torrentà, LluísPamplona Gras, ReinaldSol, JoaquimJové Font, MarionaRicart, WifredoPortero Otín, ManuelMaldonado, RafaelFernández Real, José ManuelIntestinal microbiologyObesityBackground Inhibitory control (IC) is critical to keep long-term goals in everyday life. Bidirectional relationships between IC deficits and obesity are behind unhealthy eating and physical exercise habits. Methods We studied gut microbiome composition and functionality, and plasma and faecal metabolomics in association with cognitive tests evaluating inhibitory control (Stroop test) and brain structure in a discovery (n=156), both cross-sectionally and longitudinally, and in an independent replication cohort (n=970). Faecal microbiota transplantation (FMT) in mice evaluated the impact on reversal learning and medial prefrontal cortex (mPFC) transcriptomics. Results An interplay among IC, brain structure (in humans) and mPFC transcriptomics (in mice), plasma/faecal metabolomics and the gut metagenome was found. Obesity-dependent alterations in one-carbon metabolism, tryptophan and histidine pathways were associated with IC in the two independent cohorts. Bacterial functions linked to one-carbon metabolism (thyX,dut, exodeoxyribonuclease V), and the anterior cingulate cortex volume were associated with IC, cross-sectionally and longitudinally. FMT from individuals with obesity led to alterations in mice reversal learning. In an independent FMT experiment, human donor’s bacterial functions related to IC deficits were associated with mPFC expression of one-carbon metabolism-related genes of recipient’s mice. Conclusion These results highlight the importance of targeting obesity-related impulsive behaviour through the induction of gut microbiota shifts.This work was partially supported by research grants FIS (PI15/01934 and PI18/01022) from the Instituto de Salud Carlos III from Spain, SAF2015- 65878-R and #AEI-SAF2017-84060-R-FEDER from Ministry of Economy and Competitiveness, Prometeo/2018/A/133 from Generalitat Valenciana, Spain; and also by Fondo Europeo de Desarrollo Regional (FEDER) funds, European Commission (FP7, NeuroPain #2013-602891), the Catalan Government (AGAUR, #SGR2017-669, ICREA Academia Award 2015), the Spanish Instituto de Salud Carlos III (RTA, #RD16/0017/0020), the Spanish Ministry of Science, Innovation and Universities (RTI2018-099200-B-I00), the Catalan Goverment (Agency for Management of University and Research Grants [2017SGR696] and Department of Health [STL002/16/00250]; the European Regional Development Fund (project No. 01.2.2-LMT-K-718-02-0014) under grant agreement with the Research Council of Lithuania (LMTLT); and the Project ThinkGut (EFA345/19) 65% co-financed by the European Regional Development Fund (ERDF) through the Interreg V-A SpainFrance-Andorra programme (POCTEFA 2014-2020). MA-R is funded by a predoctoral Río Hortega contract from the Instituto de Salud Carlos III (ISCIII, CM19/00190), co-funded by the European Social Fund “Investing in your future”. OC-R is funded by the Miguel Servet Program from the Instituto de Salud Carlos III (ISCIII CP20/00165), co-funded by the Europeran Social Fund "Investing in your future". JM-P is funded by the Miguel Servet Program from the Instituto de Salud Carlos III (ISCIII CP18/00009), co-funded by the European Social Fund “Investing in your future”. JS is funded by a predoctoral PERIS contract (SLT002/16/00250) from the Catalan Government. MJ is a professor under the “Serra Hunter” programme (Generalitat de Catalunya).BMJ Publishing GroupBritish Society of Gastroenterology2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://doi.org/10.1136/gutjnl-2020-323371http://hdl.handle.net/10459.1/71488reponame:Repositori Obert UdL instname:Universitat de Lleida (UdL)Inglésinfo:eu-repo/grantAgreement/MINECO//SAF2015-65878-Rinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2017-84060-RReproducció del document publicat a: http://doi.org/10.1136/gutjnl-2020-323371Gut, 2021, vol. 0, p. 1-14info:eu-repo/grantAgreement/EC/FP7/602891cc-by-nc, (c) Armoriaga et al., 2021info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc/4.0/oai:repositori.udl.cat:10459.1/714882026-06-24T12:42:17Z |
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