Structural integrity of the contralesional hemisphere predicts cognitive impairment in chronic stroke

After stroke, white matter integrity can be affected both locally and distally to the primary lesion location. It has been shown that tract disruption in mirror's regions of the contralateral hemisphere is associated with degree of functional impairment. Fourteen patients suffering right hemisp...

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Autores: Dacosta-Aguayo, Rosalia, Graña, Manuel, Fernández Andújar, Marina, López Cancio, Elena, Cáceres, Cynthia, Bargalló Alabart, Núria, Barrios Cerrejón, M. Teresa, Clemente, Immaculada, Dávalos, Antoni, Auer, Tibor, Mataró Serrat, Maria
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/113702
Acceso en línea:https://hdl.handle.net/2445/113702
Access Level:acceso abierto
Palabra clave:Neuropsicologia
Lesions cerebrals
Tests neuropsicològics
Neuropsychology
Brain damage
Neuropsychological tests
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spelling Structural integrity of the contralesional hemisphere predicts cognitive impairment in chronic strokeDacosta-Aguayo, RosaliaGraña, ManuelFernández Andújar, MarinaLópez Cancio, ElenaCáceres, CynthiaBargalló Alabart, NúriaBarrios Cerrejón, M. TeresaClemente, ImmaculadaDávalos, AntoniAuer, TiborMataró Serrat, MariaNeuropsicologiaLesions cerebralsTests neuropsicològicsNeuropsychologyBrain damageNeuropsychological testsAfter stroke, white matter integrity can be affected both locally and distally to the primary lesion location. It has been shown that tract disruption in mirror's regions of the contralateral hemisphere is associated with degree of functional impairment. Fourteen patients suffering right hemispheric focal stroke (S) and eighteen healthy controls (HC) underwent Diffusion Weighted Imaging (DWI) and neuropsychological assessment. The stroke patient group was divided into poor (SP; n = 8) and good (SG; n = 6) cognitive recovery groups according to their cognitive improvement from the acute phase (72 hours after stroke) to the subacute phase (3 months post-stroke). Whole-brain DWI data analysis was performed by computing Diffusion Tensor Imaging (DTI) followed by Tract Based Spatial Statistics (TBSS). Assessment of effects was obtained computing the correlation of the projections on TBSS skeleton of Fractional Anisotropy (FA) and Radial Diffusivity (RD) with cognitive test results. Significant decrease of FA was found only in right brain anatomical areas for the S group when compared to the HC group. Analyzed separately, stroke patients with poor cognitive recovery showed additional significant FA decrease in several left hemisphere regions; whereas SG patients showed significant decrease only in the left genu of corpus callosum when compared to the HC. For the SG group, whole brain analysis revealed significant correlation between the performance in the Semantic Fluency test and the FA in the right hemisphere as well as between the performance in the Grooved Pegboard Test (GPT) and theTrail Making Test-part A and the FA in the left hemisphere. For the SP group, correlation analysis revealed significant correlation between the performance in the GPT and the FA in the right hemisphere.Public Library of Science (PLoS)2017201720142017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion11 p.application/pdfhttps://hdl.handle.net/2445/113702Articles publicats en revistes (Psicologia Social i Psicologia Quantitativa)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1371/journal.pone.0086119PLoS One, 2014, vol. 9, num. 1, p. 1-11https://doi.org/10.1371/journal.pone.0086119cc-by (c) Dacosta Aguayo, Rosalia et al., 2014http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1137022026-05-29T05:05:01Z
dc.title.none.fl_str_mv Structural integrity of the contralesional hemisphere predicts cognitive impairment in chronic stroke
title Structural integrity of the contralesional hemisphere predicts cognitive impairment in chronic stroke
spellingShingle Structural integrity of the contralesional hemisphere predicts cognitive impairment in chronic stroke
Dacosta-Aguayo, Rosalia
Neuropsicologia
Lesions cerebrals
Tests neuropsicològics
Neuropsychology
Brain damage
Neuropsychological tests
title_short Structural integrity of the contralesional hemisphere predicts cognitive impairment in chronic stroke
title_full Structural integrity of the contralesional hemisphere predicts cognitive impairment in chronic stroke
title_fullStr Structural integrity of the contralesional hemisphere predicts cognitive impairment in chronic stroke
title_full_unstemmed Structural integrity of the contralesional hemisphere predicts cognitive impairment in chronic stroke
title_sort Structural integrity of the contralesional hemisphere predicts cognitive impairment in chronic stroke
dc.creator.none.fl_str_mv Dacosta-Aguayo, Rosalia
Graña, Manuel
Fernández Andújar, Marina
López Cancio, Elena
Cáceres, Cynthia
Bargalló Alabart, Núria
Barrios Cerrejón, M. Teresa
Clemente, Immaculada
Dávalos, Antoni
Auer, Tibor
Mataró Serrat, Maria
author Dacosta-Aguayo, Rosalia
author_facet Dacosta-Aguayo, Rosalia
Graña, Manuel
Fernández Andújar, Marina
López Cancio, Elena
Cáceres, Cynthia
Bargalló Alabart, Núria
Barrios Cerrejón, M. Teresa
Clemente, Immaculada
Dávalos, Antoni
Auer, Tibor
Mataró Serrat, Maria
author_role author
author2 Graña, Manuel
Fernández Andújar, Marina
López Cancio, Elena
Cáceres, Cynthia
Bargalló Alabart, Núria
Barrios Cerrejón, M. Teresa
Clemente, Immaculada
Dávalos, Antoni
Auer, Tibor
Mataró Serrat, Maria
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Neuropsicologia
Lesions cerebrals
Tests neuropsicològics
Neuropsychology
Brain damage
Neuropsychological tests
topic Neuropsicologia
Lesions cerebrals
Tests neuropsicològics
Neuropsychology
Brain damage
Neuropsychological tests
description After stroke, white matter integrity can be affected both locally and distally to the primary lesion location. It has been shown that tract disruption in mirror's regions of the contralateral hemisphere is associated with degree of functional impairment. Fourteen patients suffering right hemispheric focal stroke (S) and eighteen healthy controls (HC) underwent Diffusion Weighted Imaging (DWI) and neuropsychological assessment. The stroke patient group was divided into poor (SP; n = 8) and good (SG; n = 6) cognitive recovery groups according to their cognitive improvement from the acute phase (72 hours after stroke) to the subacute phase (3 months post-stroke). Whole-brain DWI data analysis was performed by computing Diffusion Tensor Imaging (DTI) followed by Tract Based Spatial Statistics (TBSS). Assessment of effects was obtained computing the correlation of the projections on TBSS skeleton of Fractional Anisotropy (FA) and Radial Diffusivity (RD) with cognitive test results. Significant decrease of FA was found only in right brain anatomical areas for the S group when compared to the HC group. Analyzed separately, stroke patients with poor cognitive recovery showed additional significant FA decrease in several left hemisphere regions; whereas SG patients showed significant decrease only in the left genu of corpus callosum when compared to the HC. For the SG group, whole brain analysis revealed significant correlation between the performance in the Semantic Fluency test and the FA in the right hemisphere as well as between the performance in the Grooved Pegboard Test (GPT) and theTrail Making Test-part A and the FA in the left hemisphere. For the SP group, correlation analysis revealed significant correlation between the performance in the GPT and the FA in the right hemisphere.
publishDate 2014
dc.date.none.fl_str_mv 2014
2017
2017
2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/113702
url https://hdl.handle.net/2445/113702
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0086119
PLoS One, 2014, vol. 9, num. 1, p. 1-11
https://doi.org/10.1371/journal.pone.0086119
dc.rights.none.fl_str_mv cc-by (c) Dacosta Aguayo, Rosalia et al., 2014
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Dacosta Aguayo, Rosalia et al., 2014
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 11 p.
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv Articles publicats en revistes (Psicologia Social i Psicologia Quantitativa)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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