Helicobacter pylori serological biomarkers of gastric cancer risk in the MCC-Spain case-control Study

BACKGROUND: Helicobacter pylori infection is one of the main risk factors for non-cardia gastric cancer. However, only a minority of infected persons develop the disease. This study aims at identifying H. pylori related serological biomarkers of risk for gastric cancer. METHODS: Incident gastric can...

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Autores: Fernández de Larrea-Baz, Nerea, Castaño Vinyals, Gemma, Kogevinas, Manolis, Aragonés, Núria
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2017
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/34504
Acceso en línea:http://hdl.handle.net/10230/34504
http://dx.doi.org/10.1016/j.canep.2017.08.002
Access Level:acceso abierto
Palabra clave:Helicobacteri pilòric
Infeccions per helicobacter pylori
Marcadors bioquímics
Aparell digestiu -- Càncer
Estómac -- Càncer
Biomarkers
Case-control studies
Gastric neoplasm
Helicobacter pylori infection
Multiplex serology
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spelling Helicobacter pylori serological biomarkers of gastric cancer risk in the MCC-Spain case-control StudyFernández de Larrea-Baz, NereaCastaño Vinyals, GemmaKogevinas, ManolisAragonés, NúriaHelicobacteri pilòricInfeccions per helicobacter pyloriMarcadors bioquímicsAparell digestiu -- CàncerEstómac -- CàncerBiomarkersCase-control studiesGastric neoplasmHelicobacter pylori infectionMultiplex serologyBACKGROUND: Helicobacter pylori infection is one of the main risk factors for non-cardia gastric cancer. However, only a minority of infected persons develop the disease. This study aims at identifying H. pylori related serological biomarkers of risk for gastric cancer. METHODS: Incident gastric cancer cases and population controls (age, sex and region frequency-matched) from the MCC-Spain multicase-control Study were included. Seroreactivities against 16H. pylori proteins were determined using multiplex serology. Infection was defined as seropositivity against≥4 proteins. Relation of serological results to non-cardia and cardia gastric cancer was assessed using multivariable mixed logistic regression and principal components analysis. RESULTS: Seroprevalence was 88% among 2071 controls, 95% among 202 non-cardia gastric cancer cases (OR=1.9 (95% CI: 1.0-3.6)) and 85% among 62 cardia cancer cases (OR=0.5 (95% CI: 0.3-1.1)). In infected subjects, seropositivity for UreA, HP231, NapA and Cagδ was associated with lower non-cardia gastric cancer risk, while seropositivity for CagA and VacA was associated with higher risk. Seropositivity for CagA and seronegativity for Cagδ maintained the association after additional adjustment by serostatus of significant proteins. We identified two antibody reactivity patterns: the "virulent-pattern", related to a threefold higher risk of non-cardia gastric cancer and the "non-virulent pattern", related to a 60% decreased risk (4th vs. first quartile). CONCLUSIONS: In our population, people seropositive for H. pylori were characterized by two patterns of antibody reactivity against H. pylori proteins: 1) Combined high seroreactivity against several proteins, associated with a lower non-cardia gastric cancer risk, and 2) High seroreactivity against CagA and VacA, associated with an increased risk.Elsevier20182017info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/34504http://dx.doi.org/10.1016/j.canep.2017.08.002reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésCancer Epidemiology. 2017 Oct;50(Pt A):76-84© Elsevier http://dx.doi.org/10.1016/j.canep.2017.08.002info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/345042026-06-12T07:21:37Z
dc.title.none.fl_str_mv Helicobacter pylori serological biomarkers of gastric cancer risk in the MCC-Spain case-control Study
title Helicobacter pylori serological biomarkers of gastric cancer risk in the MCC-Spain case-control Study
spellingShingle Helicobacter pylori serological biomarkers of gastric cancer risk in the MCC-Spain case-control Study
Fernández de Larrea-Baz, Nerea
Helicobacteri pilòric
Infeccions per helicobacter pylori
Marcadors bioquímics
Aparell digestiu -- Càncer
Estómac -- Càncer
Biomarkers
Case-control studies
Gastric neoplasm
Helicobacter pylori infection
Multiplex serology
title_short Helicobacter pylori serological biomarkers of gastric cancer risk in the MCC-Spain case-control Study
title_full Helicobacter pylori serological biomarkers of gastric cancer risk in the MCC-Spain case-control Study
title_fullStr Helicobacter pylori serological biomarkers of gastric cancer risk in the MCC-Spain case-control Study
title_full_unstemmed Helicobacter pylori serological biomarkers of gastric cancer risk in the MCC-Spain case-control Study
title_sort Helicobacter pylori serological biomarkers of gastric cancer risk in the MCC-Spain case-control Study
dc.creator.none.fl_str_mv Fernández de Larrea-Baz, Nerea
Castaño Vinyals, Gemma
Kogevinas, Manolis
Aragonés, Núria
author Fernández de Larrea-Baz, Nerea
author_facet Fernández de Larrea-Baz, Nerea
Castaño Vinyals, Gemma
Kogevinas, Manolis
Aragonés, Núria
author_role author
author2 Castaño Vinyals, Gemma
Kogevinas, Manolis
Aragonés, Núria
author2_role author
author
author
dc.subject.none.fl_str_mv Helicobacteri pilòric
Infeccions per helicobacter pylori
Marcadors bioquímics
Aparell digestiu -- Càncer
Estómac -- Càncer
Biomarkers
Case-control studies
Gastric neoplasm
Helicobacter pylori infection
Multiplex serology
topic Helicobacteri pilòric
Infeccions per helicobacter pylori
Marcadors bioquímics
Aparell digestiu -- Càncer
Estómac -- Càncer
Biomarkers
Case-control studies
Gastric neoplasm
Helicobacter pylori infection
Multiplex serology
description BACKGROUND: Helicobacter pylori infection is one of the main risk factors for non-cardia gastric cancer. However, only a minority of infected persons develop the disease. This study aims at identifying H. pylori related serological biomarkers of risk for gastric cancer. METHODS: Incident gastric cancer cases and population controls (age, sex and region frequency-matched) from the MCC-Spain multicase-control Study were included. Seroreactivities against 16H. pylori proteins were determined using multiplex serology. Infection was defined as seropositivity against≥4 proteins. Relation of serological results to non-cardia and cardia gastric cancer was assessed using multivariable mixed logistic regression and principal components analysis. RESULTS: Seroprevalence was 88% among 2071 controls, 95% among 202 non-cardia gastric cancer cases (OR=1.9 (95% CI: 1.0-3.6)) and 85% among 62 cardia cancer cases (OR=0.5 (95% CI: 0.3-1.1)). In infected subjects, seropositivity for UreA, HP231, NapA and Cagδ was associated with lower non-cardia gastric cancer risk, while seropositivity for CagA and VacA was associated with higher risk. Seropositivity for CagA and seronegativity for Cagδ maintained the association after additional adjustment by serostatus of significant proteins. We identified two antibody reactivity patterns: the "virulent-pattern", related to a threefold higher risk of non-cardia gastric cancer and the "non-virulent pattern", related to a 60% decreased risk (4th vs. first quartile). CONCLUSIONS: In our population, people seropositive for H. pylori were characterized by two patterns of antibody reactivity against H. pylori proteins: 1) Combined high seroreactivity against several proteins, associated with a lower non-cardia gastric cancer risk, and 2) High seroreactivity against CagA and VacA, associated with an increased risk.
publishDate 2017
dc.date.none.fl_str_mv 2017
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/34504
http://dx.doi.org/10.1016/j.canep.2017.08.002
url http://hdl.handle.net/10230/34504
http://dx.doi.org/10.1016/j.canep.2017.08.002
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Cancer Epidemiology. 2017 Oct;50(Pt A):76-84
dc.rights.none.fl_str_mv © Elsevier http://dx.doi.org/10.1016/j.canep.2017.08.002
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © Elsevier http://dx.doi.org/10.1016/j.canep.2017.08.002
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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