PKCα-Mediated Downregulation of RhoA Activity in Depolarized Vascular Smooth Muscle: Synergistic Vasorelaxant Effect of PKCα and ROCK Inhibition

[Background/Aims] Protein kinase C (PKC)- and RhoA/Rho-associated kinase (ROCK) play important roles in arterial sustained contraction. Although depolarization-elicited RhoA/ROCK activation is accepted, the role of PKC in depolarized vascular smooth muscle cells (VSMCs) is a subject of controversy....

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Detalles Bibliográficos
Autores: González-Montelongo, María del Carmen, Porras-González, Cristina, González-Montelongo, Rafaela, Revilla-González, Gonzalo, Pastor, María Dolores, Castellano, Antonio, Ureña, Juan
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/203276
Acceso en línea:http://hdl.handle.net/10261/203276
Access Level:acceso abierto
Palabra clave:Protein kinase C (PKC)
Rho (Rho GTPase)
Vascular smooth muscle cells
Calcium channels
Cell signalling
Phorbol ester
Depolarization
Descripción
Sumario:[Background/Aims] Protein kinase C (PKC)- and RhoA/Rho-associated kinase (ROCK) play important roles in arterial sustained contraction. Although depolarization-elicited RhoA/ROCK activation is accepted, the role of PKC in depolarized vascular smooth muscle cells (VSMCs) is a subject of controversy. Our aim was to study the role of PKC in arterial contraction and its interaction with RhoA/ROCK.

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