Resveratrol, Metabolic Syndrome, and Gut Microbiota
Resveratrol is a polyphenol which has been shown to have beneficial effects on metabolic syndrome-related alterations in experimental animals, including glucose and lipid homeostasis improvement and a reduction in fat mass, blood pressure, low-grade inflammation, and oxidative stress. Clinical trial...
| Autores: | , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2018 |
| País: | España |
| Institución: | Instituto de Salud Carlos III (ISCIII) |
| Repositorio: | Repisalud |
| Idioma: | inglés |
| OAI Identifier: | oai:repisalud.isciii.es:20.500.12105/22588 |
| Acceso en línea: | https://hdl.handle.net/20.500.12105/22588 |
| Access Level: | acceso abierto |
| Palabra clave: | Resveratrol Gut microbiota Metabolic syndrome Tracto Gastrointestinal Metaanálisis como Asunto Síndrome Metabólico Estudios Observacionales como Asunto Microbioma Gastrointestinal Grasas de la Dieta Presión Sanguínea Colesterol Humanos Ensayos Clínicos como Asunto Homeostasis Estrés Oxidativo Triglicéridos Metabolismo de los Lípidos Dieta Alta en Grasa Metabolic Syndrome: Triglycerides Oxidative Stress Clinical Trials as Topic Cholesterol Humans Observational Studies as Topic Gastrointestinal Tract Blood Pressure Dietary Fats Gastrointestinal Microbiome Meta-Analysis as Topic Lipid Metabolism Diet, High-Fat |
| Sumario: | Resveratrol is a polyphenol which has been shown to have beneficial effects on metabolic syndrome-related alterations in experimental animals, including glucose and lipid homeostasis improvement and a reduction in fat mass, blood pressure, low-grade inflammation, and oxidative stress. Clinical trials have been carried out to address its potential; however, results are still inconclusive. Even though resveratrol is partly metabolized by gut microbiota, the relevance of this forgotten organ had not been widely considered. However, in the past few years, data has emerged suggesting that the therapeutic potential of this compound may be due to its interaction with gut microbiota, reporting changes in bacterial composition associated with beneficial metabolic outcomes. Even though data is still scarce and for the most part observational, it is promising nevertheless, suggesting that resveratrol supplementation could be a useful tool for the treatment of metabolic syndrome and its associated conditions. |
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