A Comprehensive Transcriptional Signature in Pancreatic Ductal Adenocarcinoma Reveals New Insights into the Immune and Desmoplastic Microenvironments

[EN] Pancreatic ductal adenocarcinoma (PDAC) prognoses and treatment responses remain devastatingly poor due partly to the highly heterogeneous, aggressive, and immunosuppressive nature of this tumor type. The intricate relationship between the stroma, inflammation, and immunity remains vaguely unde...

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Autores: Pérez-Díez, Irene, Andreu, Zoraida, Hidalgo, Marta R., Perpiñá-Clérigues, Carla, Fantín, Lucía, Fernández-Serra, Antonio, López-Guerrero, José A., García-García, Francisco, DE LA IGLESIA VAYÁ, MARIA DE LOS DESAMPARADOS
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universitat Politècnica de València (UPV)
Repositorio:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Idioma:inglés
OAI Identifier:oai:riunet.upv.es:10251/203856
Acceso en línea:https://riunet.upv.es/handle/10251/203856
Access Level:acceso abierto
Palabra clave:Pancreatic ductal adenocarcinoma
Desmoplasia
Immune system
Heterogeneity cancer
Biomarkers
Molecular profile
Meta-analysis
Transcriptomics
Prognosis
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spelling A Comprehensive Transcriptional Signature in Pancreatic Ductal Adenocarcinoma Reveals New Insights into the Immune and Desmoplastic MicroenvironmentsPérez-Díez, IreneAndreu, ZoraidaHidalgo, Marta R.Perpiñá-Clérigues, CarlaFantín, LucíaFernández-Serra, AntonioLópez-Guerrero, José A.García-García, FranciscoDE LA IGLESIA VAYÁ, MARIA DE LOS DESAMPARADOSPancreatic ductal adenocarcinomaDesmoplasiaImmune systemHeterogeneity cancerBiomarkersMolecular profileMeta-analysisTranscriptomicsPrognosis[EN] Pancreatic ductal adenocarcinoma (PDAC) prognoses and treatment responses remain devastatingly poor due partly to the highly heterogeneous, aggressive, and immunosuppressive nature of this tumor type. The intricate relationship between the stroma, inflammation, and immunity remains vaguely understood in the PDAC microenvironment. Here, we performed a meta-analysis of stroma-, and immune-related gene expression in the PDAC microenvironment to improve disease prognosis and therapeutic development. We selected 21 PDAC studies from the Gene Expression Omnibus and ArrayExpress databases, including 922 samples (320 controls and 602 cases). Differential gene enrichment analysis identified 1153 significant dysregulated genes in PDAC patients that contribute to a desmoplastic stroma and an immunosuppressive environment (the hallmarks of PDAC tumors). The results highlighted two gene signatures related to the immune and stromal environments that cluster PDAC patients into high- and low-risk groups, impacting patients¿ stratification and therapeutic decision making. Moreover, HCP5, SLFN13, IRF9, IFIT2, and IFI35 immune genes are related to the prognosis of PDAC patients for the first time.This research was supported by and partially funded by the Institute of Health Carlos III (project IMPaCT-Data, exp. IMP/00019), co-funded by the European Union, European Regional Development Fund (ERDF, A way to make Europe ), and PID2021-124430OA-I00 funded by MCIN/AEI/10.13039/501100011033/FEDER, UE ( A way to make Europe ). This work has been carried out under the framework of the ULISES project: H2020-FETOPEN-2018-2019-2020-01 Contract nº: 899708.MDPI AGEuropean CommissionInstituto de Salud Carlos IIIAgencia Estatal de InvestigaciónEuropean Regional Development FundRepositorio Institucional de la Universitat Politècnica de València Riunet20232023-05-24journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://riunet.upv.es/handle/10251/203856reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valénciainstname:Universitat Politècnica de València (UPV)InglésengAgencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023 PID2021-124430OA-I00 ESTUDIO DE LAS DIFERENCIAS DE SEXO EN ENFERMEDADES NEURODEGENERATIVAS CON ABORDAJES INTEGRATIVOS DE DATOS OMICOS E IMAGEN BIOMEDICAEuropean Commission https://doi.org/10.13039/501100000780 H2020 899708 Immunological incompatibility as a basis for cancer curing and vaccinationInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 IMP%2F00019open accesshttp://purl.org/coar/access_right/c_abf2Reconocimiento (by)http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:riunet.upv.es:10251/2038562026-06-13T07:49:27Z
dc.title.none.fl_str_mv A Comprehensive Transcriptional Signature in Pancreatic Ductal Adenocarcinoma Reveals New Insights into the Immune and Desmoplastic Microenvironments
title A Comprehensive Transcriptional Signature in Pancreatic Ductal Adenocarcinoma Reveals New Insights into the Immune and Desmoplastic Microenvironments
spellingShingle A Comprehensive Transcriptional Signature in Pancreatic Ductal Adenocarcinoma Reveals New Insights into the Immune and Desmoplastic Microenvironments
Pérez-Díez, Irene
Pancreatic ductal adenocarcinoma
Desmoplasia
Immune system
Heterogeneity cancer
Biomarkers
Molecular profile
Meta-analysis
Transcriptomics
Prognosis
title_short A Comprehensive Transcriptional Signature in Pancreatic Ductal Adenocarcinoma Reveals New Insights into the Immune and Desmoplastic Microenvironments
title_full A Comprehensive Transcriptional Signature in Pancreatic Ductal Adenocarcinoma Reveals New Insights into the Immune and Desmoplastic Microenvironments
title_fullStr A Comprehensive Transcriptional Signature in Pancreatic Ductal Adenocarcinoma Reveals New Insights into the Immune and Desmoplastic Microenvironments
title_full_unstemmed A Comprehensive Transcriptional Signature in Pancreatic Ductal Adenocarcinoma Reveals New Insights into the Immune and Desmoplastic Microenvironments
title_sort A Comprehensive Transcriptional Signature in Pancreatic Ductal Adenocarcinoma Reveals New Insights into the Immune and Desmoplastic Microenvironments
dc.creator.none.fl_str_mv Pérez-Díez, Irene
Andreu, Zoraida
Hidalgo, Marta R.
Perpiñá-Clérigues, Carla
Fantín, Lucía
Fernández-Serra, Antonio
López-Guerrero, José A.
García-García, Francisco
DE LA IGLESIA VAYÁ, MARIA DE LOS DESAMPARADOS
author Pérez-Díez, Irene
author_facet Pérez-Díez, Irene
Andreu, Zoraida
Hidalgo, Marta R.
Perpiñá-Clérigues, Carla
Fantín, Lucía
Fernández-Serra, Antonio
López-Guerrero, José A.
García-García, Francisco
DE LA IGLESIA VAYÁ, MARIA DE LOS DESAMPARADOS
author_role author
author2 Andreu, Zoraida
Hidalgo, Marta R.
Perpiñá-Clérigues, Carla
Fantín, Lucía
Fernández-Serra, Antonio
López-Guerrero, José A.
García-García, Francisco
DE LA IGLESIA VAYÁ, MARIA DE LOS DESAMPARADOS
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv European Commission
Instituto de Salud Carlos III
Agencia Estatal de Investigación
European Regional Development Fund
Repositorio Institucional de la Universitat Politècnica de València Riunet
dc.subject.none.fl_str_mv Pancreatic ductal adenocarcinoma
Desmoplasia
Immune system
Heterogeneity cancer
Biomarkers
Molecular profile
Meta-analysis
Transcriptomics
Prognosis
topic Pancreatic ductal adenocarcinoma
Desmoplasia
Immune system
Heterogeneity cancer
Biomarkers
Molecular profile
Meta-analysis
Transcriptomics
Prognosis
description [EN] Pancreatic ductal adenocarcinoma (PDAC) prognoses and treatment responses remain devastatingly poor due partly to the highly heterogeneous, aggressive, and immunosuppressive nature of this tumor type. The intricate relationship between the stroma, inflammation, and immunity remains vaguely understood in the PDAC microenvironment. Here, we performed a meta-analysis of stroma-, and immune-related gene expression in the PDAC microenvironment to improve disease prognosis and therapeutic development. We selected 21 PDAC studies from the Gene Expression Omnibus and ArrayExpress databases, including 922 samples (320 controls and 602 cases). Differential gene enrichment analysis identified 1153 significant dysregulated genes in PDAC patients that contribute to a desmoplastic stroma and an immunosuppressive environment (the hallmarks of PDAC tumors). The results highlighted two gene signatures related to the immune and stromal environments that cluster PDAC patients into high- and low-risk groups, impacting patients¿ stratification and therapeutic decision making. Moreover, HCP5, SLFN13, IRF9, IFIT2, and IFI35 immune genes are related to the prognosis of PDAC patients for the first time.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-05-24
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://riunet.upv.es/handle/10251/203856
url https://riunet.upv.es/handle/10251/203856
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023 PID2021-124430OA-I00 ESTUDIO DE LAS DIFERENCIAS DE SEXO EN ENFERMEDADES NEURODEGENERATIVAS CON ABORDAJES INTEGRATIVOS DE DATOS OMICOS E IMAGEN BIOMEDICA
European Commission https://doi.org/10.13039/501100000780 H2020 899708 Immunological incompatibility as a basis for cancer curing and vaccination
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 IMP%2F00019
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento (by)
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento (by)
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI AG
publisher.none.fl_str_mv MDPI AG
dc.source.none.fl_str_mv reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname:Universitat Politècnica de València (UPV)
instname_str Universitat Politècnica de València (UPV)
reponame_str RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
collection RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301603

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