Three-dimensional structures of Lipoproteins from Streptococcus pneumoniae and Staphylococcus aureus

13 pags, 4 figs, 2 tabs

Detalles Bibliográficos
Autores: Bartual, Sergio G., Alcorlo, Martín, Martínez-Caballero, Siseth, Molina, Rafael, Hermoso, Juan A.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/251135
Acceso en línea:http://hdl.handle.net/10261/251135
Access Level:acceso abierto
Palabra clave:Streptococcus pneumoniae
Staphylococcus aureus
Lipoproteins
Protein structure
Virulence
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spelling Three-dimensional structures of Lipoproteins from Streptococcus pneumoniae and Staphylococcus aureusBartual, Sergio G.Alcorlo, MartínMartínez-Caballero, SisethMolina, RafaelHermoso, Juan A.Streptococcus pneumoniaeStaphylococcus aureusLipoproteinsProtein structureVirulence13 pags, 4 figs, 2 tabsBacterial lipoproteins (Lpp) compose a large family of surface-exposed proteins that are involved in diverse, but critical, cellular functions spanning from fitness to virulence. All of them present a common signature, a sequence motif, known as LipoBox, containing an invariant Cys residue that allows the protein to be covalently bound to the membrane through a thioether linkage. Despite the abundance and relevance of Lpp, there is a scarcity of structural and functional information for this family of proteins. In this review, the updated structural and functional data for Lpp from two Gram-positive pathogenic model organisms, Staphylococcus aureus and Streptococcus pneumoniae is presented. The available structural information offers a glimpse over the Lpp functional mechanisms. Their relevance in bacterial fitness, and also in virulence and host-pathogen interactions, reveals lipoproteins as very attractive targets for designing of novel antimicrobials, and interesting candidates as novel vaccine antigens.This work has been supported by a grant from the Spanish Ministry of Economy and Competitiveness (BFU2014-59389-P) to JAH.Elsevier BVMinisterio de Economía y Competitividad (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2021202120182021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bcPublisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/251135reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2014-59389-Phttp://dx.doi.org/10.1016/j.ijmm.2017.10.003Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2511352026-05-22T06:33:51Z
dc.title.none.fl_str_mv Three-dimensional structures of Lipoproteins from Streptococcus pneumoniae and Staphylococcus aureus
title Three-dimensional structures of Lipoproteins from Streptococcus pneumoniae and Staphylococcus aureus
spellingShingle Three-dimensional structures of Lipoproteins from Streptococcus pneumoniae and Staphylococcus aureus
Bartual, Sergio G.
Streptococcus pneumoniae
Staphylococcus aureus
Lipoproteins
Protein structure
Virulence
title_short Three-dimensional structures of Lipoproteins from Streptococcus pneumoniae and Staphylococcus aureus
title_full Three-dimensional structures of Lipoproteins from Streptococcus pneumoniae and Staphylococcus aureus
title_fullStr Three-dimensional structures of Lipoproteins from Streptococcus pneumoniae and Staphylococcus aureus
title_full_unstemmed Three-dimensional structures of Lipoproteins from Streptococcus pneumoniae and Staphylococcus aureus
title_sort Three-dimensional structures of Lipoproteins from Streptococcus pneumoniae and Staphylococcus aureus
dc.creator.none.fl_str_mv Bartual, Sergio G.
Alcorlo, Martín
Martínez-Caballero, Siseth
Molina, Rafael
Hermoso, Juan A.
author Bartual, Sergio G.
author_facet Bartual, Sergio G.
Alcorlo, Martín
Martínez-Caballero, Siseth
Molina, Rafael
Hermoso, Juan A.
author_role author
author2 Alcorlo, Martín
Martínez-Caballero, Siseth
Molina, Rafael
Hermoso, Juan A.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Streptococcus pneumoniae
Staphylococcus aureus
Lipoproteins
Protein structure
Virulence
topic Streptococcus pneumoniae
Staphylococcus aureus
Lipoproteins
Protein structure
Virulence
description 13 pags, 4 figs, 2 tabs
publishDate 2018
dc.date.none.fl_str_mv 2018
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_dcae04bc
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/251135
url http://hdl.handle.net/10261/251135
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2014-59389-P
http://dx.doi.org/10.1016/j.ijmm.2017.10.003
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier BV
publisher.none.fl_str_mv Elsevier BV
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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