Selection of new chemicals to be used in conditioned aversion for non-lethal predation control

Globally, native predators and scavengers are threatened through the incidence of illegal poisoning due to increasing human-wildlife conflicts. The use of conditioned taste aversion (CTA) may mitigate such conflicts. CTA is a robust learning paradigm that occurs when animals associate a food with a...

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Autores: Tobajas, Jorge, Gómez-Ramírez, Pilar, María-Mojica, Pedro, Navas, Isabel, García-Fernández, Antonio J., Ferreras, Pablo, Mateo, Rafael
Tipo de recurso: artículo
Estado:Versión enviada para evaluación y publicación
Fecha de publicación:2019
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/215986
Acceso en línea:http://hdl.handle.net/10261/215986
Access Level:acceso abierto
Palabra clave:Conditioned food aversion
Learned aversion
Predation conflict
Non-lethal predator control
Wildlife management
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spelling Selection of new chemicals to be used in conditioned aversion for non-lethal predation controlTobajas, JorgeGómez-Ramírez, PilarMaría-Mojica, PedroNavas, IsabelGarcía-Fernández, Antonio J.Ferreras, PabloMateo, RafaelConditioned food aversionLearned aversionPredation conflictNon-lethal predator controlWildlife managementGlobally, native predators and scavengers are threatened through the incidence of illegal poisoning due to increasing human-wildlife conflicts. The use of conditioned taste aversion (CTA) may mitigate such conflicts. CTA is a robust learning paradigm that occurs when animals associate a food with a discomfort induced by a chemical, thereby avoiding that food in subsequent encounters. We reviewed the potential of 167 chemical compounds to be used in CTA, considering effects, margin of safety, accessibility, and detectability. After the review, 15 compounds fulfilled the required characteristics, but only five (thiabendazole, thiram, levamisole, fluconazole and fluralaner) were finally selected to be tested in CTA assays with dogs. Of the tested compounds, thiabendazole, thiram and levamisole caused target food rejection by dogs and reduced the time spent eating during post-conditioning. However, despite being microencapsulated, levamisole appeared to be detectable by dogs, whereas thiram and thiabendazole were not. Fluconazole and fluralaner did not produce any CTA effect. Thiabendazole, thiram and levamisole can therefore induce CTA, and thus are potential candidates as aversive compounds for wildlife management. Thiram is an undetectable, relatively safe and accessible compound that can induce CTA in canids, and opens new possibilities to develop methods of non-lethal predation control.This study is a result of CGL2013–40975-R project, from I+D+I National Plan funded by the Spanish Ministry of Economy and Competitiveness. Jorge Tobajas benefitted from a FPI PhD scholarship (BES-2014-068987) funded by the Spanish Ministry of Economy and Competitiveness.Peer reviewedElsevierMinisterio de Economía y Competitividad (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202020202019info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Preprintinfo:eu-repo/semantics/submittedVersionhttp://hdl.handle.net/10261/215986reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CGL2013-40975-Rhttps://doi.org/10.1016/j.beproc.2019.103905Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2159862026-05-22T06:33:51Z
dc.title.none.fl_str_mv Selection of new chemicals to be used in conditioned aversion for non-lethal predation control
title Selection of new chemicals to be used in conditioned aversion for non-lethal predation control
spellingShingle Selection of new chemicals to be used in conditioned aversion for non-lethal predation control
Tobajas, Jorge
Conditioned food aversion
Learned aversion
Predation conflict
Non-lethal predator control
Wildlife management
title_short Selection of new chemicals to be used in conditioned aversion for non-lethal predation control
title_full Selection of new chemicals to be used in conditioned aversion for non-lethal predation control
title_fullStr Selection of new chemicals to be used in conditioned aversion for non-lethal predation control
title_full_unstemmed Selection of new chemicals to be used in conditioned aversion for non-lethal predation control
title_sort Selection of new chemicals to be used in conditioned aversion for non-lethal predation control
dc.creator.none.fl_str_mv Tobajas, Jorge
Gómez-Ramírez, Pilar
María-Mojica, Pedro
Navas, Isabel
García-Fernández, Antonio J.
Ferreras, Pablo
Mateo, Rafael
author Tobajas, Jorge
author_facet Tobajas, Jorge
Gómez-Ramírez, Pilar
María-Mojica, Pedro
Navas, Isabel
García-Fernández, Antonio J.
Ferreras, Pablo
Mateo, Rafael
author_role author
author2 Gómez-Ramírez, Pilar
María-Mojica, Pedro
Navas, Isabel
García-Fernández, Antonio J.
Ferreras, Pablo
Mateo, Rafael
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Conditioned food aversion
Learned aversion
Predation conflict
Non-lethal predator control
Wildlife management
topic Conditioned food aversion
Learned aversion
Predation conflict
Non-lethal predator control
Wildlife management
description Globally, native predators and scavengers are threatened through the incidence of illegal poisoning due to increasing human-wildlife conflicts. The use of conditioned taste aversion (CTA) may mitigate such conflicts. CTA is a robust learning paradigm that occurs when animals associate a food with a discomfort induced by a chemical, thereby avoiding that food in subsequent encounters. We reviewed the potential of 167 chemical compounds to be used in CTA, considering effects, margin of safety, accessibility, and detectability. After the review, 15 compounds fulfilled the required characteristics, but only five (thiabendazole, thiram, levamisole, fluconazole and fluralaner) were finally selected to be tested in CTA assays with dogs. Of the tested compounds, thiabendazole, thiram and levamisole caused target food rejection by dogs and reduced the time spent eating during post-conditioning. However, despite being microencapsulated, levamisole appeared to be detectable by dogs, whereas thiram and thiabendazole were not. Fluconazole and fluralaner did not produce any CTA effect. Thiabendazole, thiram and levamisole can therefore induce CTA, and thus are potential candidates as aversive compounds for wildlife management. Thiram is an undetectable, relatively safe and accessible compound that can induce CTA in canids, and opens new possibilities to develop methods of non-lethal predation control.
publishDate 2019
dc.date.none.fl_str_mv 2019
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Preprint
info:eu-repo/semantics/submittedVersion
format article
status_str submittedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/215986
url http://hdl.handle.net/10261/215986
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CGL2013-40975-R
https://doi.org/10.1016/j.beproc.2019.103905
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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