Minbiziaren aurkako CAR-T zelulen bidezko immunoterapia

The last years immunotherapy has become a useful strategy in the fight against cancer. One of the most popular therapies is called CAR-T. In this treatment, the patient’s T lymphocytes are removed and modified in the laboratory to enhance the action against the tumour by placing a type of “sensor” o...

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Autores: García Gallastegui, Patricia, Mugica Basauri, Maite, Crende Arruabarrena, Olatz
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/54199
Acceso en línea:http://hdl.handle.net/10810/54199
Access Level:acceso abierto
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spelling Minbiziaren aurkako CAR-T zelulen bidezko immunoterapiaGarcía Gallastegui, PatriciaMugica Basauri, MaiteCrende Arruabarrena, OlatzThe last years immunotherapy has become a useful strategy in the fight against cancer. One of the most popular therapies is called CAR-T. In this treatment, the patient’s T lymphocytes are removed and modified in the laboratory to enhance the action against the tumour by placing a type of “sensor” on its surface (CAR receptor). Thus, the patient is re- introduced with the transformed lymphocytes, which search for, recognize, and attack tumour cells. In this review, we will explain the structure, mode of generation, and adverse effects of CAR receptors on therapy. Finally, CAR-T immunotherapy has been shown to be effective in several blood tumours, as well as in certain types of solid tumors.; Azkenengo urteotan immunoterapia minbiziari aurre egiteko estrategia baliagarria bihurtu da. Terapia ezagunenetako bati CAR-T deritzo. Tratamendu honetan, gaixoaren T linfozitoak atera eta laborategian aldatu egiten dira tumorearen aurkako ekintza hobetzeko, "sentsore" mota bat jarrita haren gainazalean (CAR errezeptorea). Horrela, pazienteari berriro linfozito eraldatuak sartzen zaizkio, hauek tumore-zelulak bilatu, ezagutu eta erasotzeko. Berrikuspen honetan, CAR errezeptoreen egitura, sortzeko era eta terapiaren efektu desiragaitzak azalduko ditugu. Azkenik, CAR-T immunoterapia odoleko hainbat tumoretan eraginkorra dela frogatu da, bai eta tumore solido mota batzuetan ere.Servicio Editorial de la Universidad del País Vasco/Euskal Herriko Unibertsitatearen Argitalpen Zerbitzua202120212021info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/54199reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoEuskerainfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/© 2021 UPV/EHU Attribution-NonCommercial-ShareAlike 4.0 Internationaloai:addi.ehu.eus:10810/541992026-06-18T09:23:17Z
dc.title.none.fl_str_mv Minbiziaren aurkako CAR-T zelulen bidezko immunoterapia
title Minbiziaren aurkako CAR-T zelulen bidezko immunoterapia
spellingShingle Minbiziaren aurkako CAR-T zelulen bidezko immunoterapia
García Gallastegui, Patricia
title_short Minbiziaren aurkako CAR-T zelulen bidezko immunoterapia
title_full Minbiziaren aurkako CAR-T zelulen bidezko immunoterapia
title_fullStr Minbiziaren aurkako CAR-T zelulen bidezko immunoterapia
title_full_unstemmed Minbiziaren aurkako CAR-T zelulen bidezko immunoterapia
title_sort Minbiziaren aurkako CAR-T zelulen bidezko immunoterapia
dc.creator.none.fl_str_mv García Gallastegui, Patricia
Mugica Basauri, Maite
Crende Arruabarrena, Olatz
author García Gallastegui, Patricia
author_facet García Gallastegui, Patricia
Mugica Basauri, Maite
Crende Arruabarrena, Olatz
author_role author
author2 Mugica Basauri, Maite
Crende Arruabarrena, Olatz
author2_role author
author
description The last years immunotherapy has become a useful strategy in the fight against cancer. One of the most popular therapies is called CAR-T. In this treatment, the patient’s T lymphocytes are removed and modified in the laboratory to enhance the action against the tumour by placing a type of “sensor” on its surface (CAR receptor). Thus, the patient is re- introduced with the transformed lymphocytes, which search for, recognize, and attack tumour cells. In this review, we will explain the structure, mode of generation, and adverse effects of CAR receptors on therapy. Finally, CAR-T immunotherapy has been shown to be effective in several blood tumours, as well as in certain types of solid tumors.; Azkenengo urteotan immunoterapia minbiziari aurre egiteko estrategia baliagarria bihurtu da. Terapia ezagunenetako bati CAR-T deritzo. Tratamendu honetan, gaixoaren T linfozitoak atera eta laborategian aldatu egiten dira tumorearen aurkako ekintza hobetzeko, "sentsore" mota bat jarrita haren gainazalean (CAR errezeptorea). Horrela, pazienteari berriro linfozito eraldatuak sartzen zaizkio, hauek tumore-zelulak bilatu, ezagutu eta erasotzeko. Berrikuspen honetan, CAR errezeptoreen egitura, sortzeko era eta terapiaren efektu desiragaitzak azalduko ditugu. Azkenik, CAR-T immunoterapia odoleko hainbat tumoretan eraginkorra dela frogatu da, bai eta tumore solido mota batzuetan ere.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/54199
url http://hdl.handle.net/10810/54199
dc.language.none.fl_str_mv Euskera
language_invalid_str_mv Euskera
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
© 2021 UPV/EHU Attribution-NonCommercial-ShareAlike 4.0 International
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
© 2021 UPV/EHU Attribution-NonCommercial-ShareAlike 4.0 International
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Servicio Editorial de la Universidad del País Vasco/Euskal Herriko Unibertsitatearen Argitalpen Zerbitzua
publisher.none.fl_str_mv Servicio Editorial de la Universidad del País Vasco/Euskal Herriko Unibertsitatearen Argitalpen Zerbitzua
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
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