Brønsted Acid Catalyzed (4 + 2) Cyclocondensation of 3-Substituted Indoles with Donor–Acceptor Cyclopropanes
Acylcyclopropanes are employed as useful donor−acceptor cyclopropanes that undergo formal (4 + 2) cyclo-condensation with N-unprotected 3-substituted indoles in thepresence of a Brønsted acid catalyst. The reaction involves thesimultaneous alkylation of both the N and C-2 positions of theindole and...
| Autores: | , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universidad del País Vasco |
| Repositorio: | Addi. Archivo Digital para la Docencia y la Investigación |
| OAI Identifier: | oai:addi.ehu.eus:10810/69960 |
| Acceso en línea: | http://hdl.handle.net/10810/69960 |
| Access Level: | acceso abierto |
| Palabra clave: | donor−acceptor cyclopropanes acylcyclopropanes (4 + 2) cyclocondensation brønsted acid catalyzed |
| Sumario: | Acylcyclopropanes are employed as useful donor−acceptor cyclopropanes that undergo formal (4 + 2) cyclo-condensation with N-unprotected 3-substituted indoles in thepresence of a Brønsted acid catalyst. The reaction involves thesimultaneous alkylation of both the N and C-2 positions of theindole and provides access to the 8,9-dihydropyrido[1,2-a]indolescaffold that is the central core of several biologically relevantindole alkaloids in excellent yields and good selectivities |
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