Cohort Profile: Pregnancy And Childhood Epigenetics (PACE) Consortium

Epigenetics refers to mitotically heritable changes to the DNA, which do not affect the DNA sequence, but can influence its function. Currently, DNA methylation is the most studied epigenetic phenomenon in large populations. It entails the binding of a methyl group, mainly to positions in genomic DN...

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Autores: Felix, Janine F., Joubert, Bonnie R., Baccarelli, Andrea A., Sharp, Gemma C., Almqvist, Catarina, Annesi-Maesano, Isabella, Arshad, Hasan, Baiz, Nour, Bakermans-Kranenburg, Marian J., Bakulski, Kelly M., Binder, Elisabeth B., Plusquin, Michelle, Tiemeier, Henning, Raikkonen, Katri, Rzehak, Peter, Wang, Pei, Reese, Sarah E., Reischl, Eva, Richiardi, Lorenzo, Ring, Susan M., Schwartz, David A., Wiemels, Joseph L., Taylor, Jack A., Yousefi, Paul, Sebert, Sylvain, Snieder, Harold, Sorensen, Thorkild I. A., Starling, Anne P., Ullemar, Vilhelmina, Zhang, Weiming, Vafeiadi, Marina, Bouchard, Luigi, Brunekreef, Bert, Van Ijzendoorn, Marinus H., Vonk, Judith M., Vriens, Annette, Vrijheid, Martine, Wilcox, Allen J., Zhang, Hongmei, Czamara, Darina, Wright, Rosalind J., Xu, Cheng-Jian, Xu, Zongli, Yang, Ivana V., Zhao, Shanshan, Davey Smith, George, Breton, Carrie V., Everson, Todd M., Agha, Golareh, Relton, Caroline L., Jaddoe, Vincent W., London, Stephanie J., Brunst, Kelly J., Fallin, M. Daniele, Burchard, Esteban G., Dabelea, Dana, Gonseth, Semira, Bustamante Pineda, Mariona, Chatzi, Leda, Cheng Munthe-Kaas, Monica, Corpeleijn, Eva, De Boever, Patrick, Falahi, Fahimeh, Holloway, John W., Duijts, Liesbeth, Dwyer, Terence, Eng, Celeste, Eskenazi, Brenda, Farchi, Sara, Hu, Donglei, Fernandez, Mariana F., Karagas, Margaret R., Gao, Lu, Gaunt, Tom R., Ghantous, Akram, Gillman, Matthew W., Grote, Veit, Karmaus, Wilfried, Gruzieva, Olena, Hoyo, Cathrine, Ladd-Acosta, Christine, Haberg, Siri E., Herceg, Zdenko, Hivert, Marie-France, Holland, Nina, Huang, Rae-Chi, Karlsson, Robert, Magnus, Per, Huen, Karen, Jarvelin, Marjo-Riitta, Jima, Dereje D., Just, Allan C., Kechris, Katerina J., Marsit, Carmen J., Kere, Juha, Nistico, Lorenza, Kogevinas, Manolis, Koletzko, B. (Berthold), Koppelman, Gerard H., Kupers, Leanne K., Lahti, Jari, Nordlund, Bjorn, Lambrechts, Nathalie, Maguire, Rachel L., Pizzi, Costanza, Langie, Sabine A. S., Lie, Rolv T., Liu, Andrew H., Magnus, Maria C., McArdle, Wendy, Nohr, Ellen Aagard, Roy, Ritu, Melén, Erik, Melton, Phillip E., Murphy, Susan K., Nawrot, Tim S., Nystad, Wenche, Schoeters, Greet, Oh, Sam S., Sunyer Deu, Jordi, Oken, Emily, Page, Christian Magnus, Perron, Patrice, Pershagen, Göran
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/117488
Acceso en línea:https://hdl.handle.net/2445/117488
Access Level:acceso abierto
Palabra clave:Epigenètica
Embaràs
Epigenetics
Pregnancy
Descripción
Sumario:Epigenetics refers to mitotically heritable changes to the DNA, which do not affect the DNA sequence, but can influence its function. Currently, DNA methylation is the most studied epigenetic phenomenon in large populations. It entails the binding of a methyl group, mainly to positions in genomic DNA where a cytosine is located next to a guanine, a cytosine-phosphate-guanine (CpG) site (Figure 1). DNA methylation at CpG sites can influence gene expression by altering the DNA’s three-dimensional structure and interacting with methyl-binding proteins, consequently affecting the binding of the gene transcription and chromatin-modifying machinery. There are approximately 28 million CpG sites in the human genome. DNA methylation is a dynamic process that can be influenced by genetic factors, as well as by environmental factors such as diet, air pollution, toxicants or smoking.1–4 Hence, DNA methylation may be seen as linking the genome to the environment with respect to health and disease. Early development is a period of profound changes in DNA methylation and may, as such, be a critical period for environmentally-induced DNA methylation changes.4 Hence, this period is of specific interest for DNA methylation studies in relation to specific exposures and long-term health outcomes

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