Editorial: Environmental factors affecting the germ line epigenome

Environmental influences on the male germ cell epigenome can promote male infertility. In recent years, epigenetic mechanisms regulating gene expression have thus raised much interest in reproductive biology, given the possibility of inherited acquired traits through the germ line . Environmental fa...

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Detalles Bibliográficos
Autores: Vitullo, Alfredo D., Roldán, Eduardo R. S., González, Candela R.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/297159
Acceso en línea:http://hdl.handle.net/10261/297159
Access Level:acceso abierto
Palabra clave:Epigenetics
Germline
Environmental factors
Epigenome
Gene expression
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spelling Editorial: Environmental factors affecting the germ line epigenomeVitullo, Alfredo D.Roldán, Eduardo R. S.González, Candela R.EpigeneticsGermlineEnvironmental factorsEpigenomeGene expressionEnvironmental influences on the male germ cell epigenome can promote male infertility. In recent years, epigenetic mechanisms regulating gene expression have thus raised much interest in reproductive biology, given the possibility of inherited acquired traits through the germ line . Environmental factors can induce changes in gene expression without altering DNA sequence through mechanisms including DNA methylation, histone post-translational modifications (PTMs), chromatin remodeling, and non-coding RNAs ). These mechanisms differentially signal chromatin states promoting open/transcription-permissive or closed/repressed states, or modifying the activity of regulatory elements such as enhancers and promoters . Diet, sedentary life, drug consumption or abuse, and exposure to endocrine disruptors may induce stable modifications of the mammalian germline and contribute to trans-generational effects. Therefore, much current research is focused on determining how environmental factors influence the germ cell epigenome, if they do, to encode transmissible, acquired traits. This Research Topic gathers several contributions highlighting possible environmental influences on male germ cell epigenome which can result in male infertility. The first article on this Topic (Faure et al., 2021) shows that in-utero exposure to metformin lowers male fertility without changes in sperm production or motility, likely promoted by hypermethylation of genomic DNA associated with a decreased expression of TET1. After birth, we learn through the study of Fenclová et al. (2022), that exposure to endocrine disruptors, such as bisphenols, through maternal milk promotes changes in H3 dimethylation and H2 phosphorylation. These epigenetic changes affect early embryonic development, the quality of germ cells, and thus spermatozoa, which could be the origin of male idiopathic infertility.Peer reviewedFrontiers MediaConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202320232023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_b239Publisher's versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/contributionToPeriodicalhttp://hdl.handle.net/10261/297159reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.3389/fendo.2022.1126967Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2971592026-05-22T06:33:51Z
dc.title.none.fl_str_mv Editorial: Environmental factors affecting the germ line epigenome
title Editorial: Environmental factors affecting the germ line epigenome
spellingShingle Editorial: Environmental factors affecting the germ line epigenome
Vitullo, Alfredo D.
Epigenetics
Germline
Environmental factors
Epigenome
Gene expression
title_short Editorial: Environmental factors affecting the germ line epigenome
title_full Editorial: Environmental factors affecting the germ line epigenome
title_fullStr Editorial: Environmental factors affecting the germ line epigenome
title_full_unstemmed Editorial: Environmental factors affecting the germ line epigenome
title_sort Editorial: Environmental factors affecting the germ line epigenome
dc.creator.none.fl_str_mv Vitullo, Alfredo D.
Roldán, Eduardo R. S.
González, Candela R.
author Vitullo, Alfredo D.
author_facet Vitullo, Alfredo D.
Roldán, Eduardo R. S.
González, Candela R.
author_role author
author2 Roldán, Eduardo R. S.
González, Candela R.
author2_role author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Epigenetics
Germline
Environmental factors
Epigenome
Gene expression
topic Epigenetics
Germline
Environmental factors
Epigenome
Gene expression
description Environmental influences on the male germ cell epigenome can promote male infertility. In recent years, epigenetic mechanisms regulating gene expression have thus raised much interest in reproductive biology, given the possibility of inherited acquired traits through the germ line . Environmental factors can induce changes in gene expression without altering DNA sequence through mechanisms including DNA methylation, histone post-translational modifications (PTMs), chromatin remodeling, and non-coding RNAs ). These mechanisms differentially signal chromatin states promoting open/transcription-permissive or closed/repressed states, or modifying the activity of regulatory elements such as enhancers and promoters . Diet, sedentary life, drug consumption or abuse, and exposure to endocrine disruptors may induce stable modifications of the mammalian germline and contribute to trans-generational effects. Therefore, much current research is focused on determining how environmental factors influence the germ cell epigenome, if they do, to encode transmissible, acquired traits. This Research Topic gathers several contributions highlighting possible environmental influences on male germ cell epigenome which can result in male infertility. The first article on this Topic (Faure et al., 2021) shows that in-utero exposure to metformin lowers male fertility without changes in sperm production or motility, likely promoted by hypermethylation of genomic DNA associated with a decreased expression of TET1. After birth, we learn through the study of Fenclová et al. (2022), that exposure to endocrine disruptors, such as bisphenols, through maternal milk promotes changes in H3 dimethylation and H2 phosphorylation. These epigenetic changes affect early embryonic development, the quality of germ cells, and thus spermatozoa, which could be the origin of male idiopathic infertility.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_b239
Publisher's version
info:eu-repo/semantics/publishedVersion
dc.type.openaire.fl_str_mv info:eu-repo/semantics/contributionToPeriodical
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/297159
url http://hdl.handle.net/10261/297159
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.3389/fendo.2022.1126967
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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