A Multifunctional Trypsin Protease Inhibitor from Yellow Bell Pepper Seeds

Fungal infections are a growing public health concern worldwide and the emergence of antifungal resistance has limited the number of therapeutic options. Therefore, developing novel strategies for identifying and developing new antifungal compounds is an active area of research in the pharmaceutical...

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Autores: Cotabarren, Juliana|||0000-0001-7132-473X, Ozón, Brenda|||0009-0003-6368-3742, Claver, Santiago, Geier, Florencia, Rossotti, Martina, Garcia-Pardo, Javier|||0000-0001-9179-6371, Obregón, Walter David
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:281956
Acceso en línea:https://ddd.uab.cat/record/281956
https://dx.doi.org/urn:doi:10.3390/pharmaceutics15030781
Access Level:acceso abierto
Palabra clave:Antifungal
Bioactive compound
Bioactive peptide
Capsicum annuum L.
Candida albicans
Protease
Protease inhibitor
Phytocystatin
Trypsin inhibitor
Natural product
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spelling A Multifunctional Trypsin Protease Inhibitor from Yellow Bell Pepper SeedsUncovering Its Dual Antifungal and Hypoglycemic PropertiesCotabarren, Juliana|||0000-0001-7132-473XOzón, Brenda|||0009-0003-6368-3742Claver, SantiagoGeier, FlorenciaRossotti, MartinaGarcia-Pardo, Javier|||0000-0001-9179-6371Obregón, Walter DavidAntifungalBioactive compoundBioactive peptideCapsicum annuum L.Candida albicansProteaseProtease inhibitorPhytocystatinTrypsin inhibitorNatural productFungal infections are a growing public health concern worldwide and the emergence of antifungal resistance has limited the number of therapeutic options. Therefore, developing novel strategies for identifying and developing new antifungal compounds is an active area of research in the pharmaceutical industry. In this study, we purified and characterized a trypsin protease inhibitor obtained from Yellow Bell Pepper (Capsicum annuum L.) seeds. The inhibitor not only showed potent and specific activity against the pathogenic fungus Candida albicans, but was also found to be non-toxic against human cells. Furthermore, this inhibitor is unique in that it also inhibits α-1,4-glucosidase, positioning it as one of the first plant-derived protease inhibitors with dual biological activity. This exciting discovery opens new avenues for the development of this inhibitor as a promising antifungal agent and highlights the potential of plant-derived protease inhibitors as a rich source for the discovery of novel multifunctional bioactive molecules.Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular 22023-01-0120232023-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/281956https://dx.doi.org/urn:doi:10.3390/pharmaceutics15030781reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2819562026-06-06T12:50:31Z
dc.title.none.fl_str_mv A Multifunctional Trypsin Protease Inhibitor from Yellow Bell Pepper Seeds
Uncovering Its Dual Antifungal and Hypoglycemic Properties
title A Multifunctional Trypsin Protease Inhibitor from Yellow Bell Pepper Seeds
spellingShingle A Multifunctional Trypsin Protease Inhibitor from Yellow Bell Pepper Seeds
Cotabarren, Juliana|||0000-0001-7132-473X
Antifungal
Bioactive compound
Bioactive peptide
Capsicum annuum L.
Candida albicans
Protease
Protease inhibitor
Phytocystatin
Trypsin inhibitor
Natural product
title_short A Multifunctional Trypsin Protease Inhibitor from Yellow Bell Pepper Seeds
title_full A Multifunctional Trypsin Protease Inhibitor from Yellow Bell Pepper Seeds
title_fullStr A Multifunctional Trypsin Protease Inhibitor from Yellow Bell Pepper Seeds
title_full_unstemmed A Multifunctional Trypsin Protease Inhibitor from Yellow Bell Pepper Seeds
title_sort A Multifunctional Trypsin Protease Inhibitor from Yellow Bell Pepper Seeds
dc.creator.none.fl_str_mv Cotabarren, Juliana|||0000-0001-7132-473X
Ozón, Brenda|||0009-0003-6368-3742
Claver, Santiago
Geier, Florencia
Rossotti, Martina
Garcia-Pardo, Javier|||0000-0001-9179-6371
Obregón, Walter David
author Cotabarren, Juliana|||0000-0001-7132-473X
author_facet Cotabarren, Juliana|||0000-0001-7132-473X
Ozón, Brenda|||0009-0003-6368-3742
Claver, Santiago
Geier, Florencia
Rossotti, Martina
Garcia-Pardo, Javier|||0000-0001-9179-6371
Obregón, Walter David
author_role author
author2 Ozón, Brenda|||0009-0003-6368-3742
Claver, Santiago
Geier, Florencia
Rossotti, Martina
Garcia-Pardo, Javier|||0000-0001-9179-6371
Obregón, Walter David
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
dc.subject.none.fl_str_mv Antifungal
Bioactive compound
Bioactive peptide
Capsicum annuum L.
Candida albicans
Protease
Protease inhibitor
Phytocystatin
Trypsin inhibitor
Natural product
topic Antifungal
Bioactive compound
Bioactive peptide
Capsicum annuum L.
Candida albicans
Protease
Protease inhibitor
Phytocystatin
Trypsin inhibitor
Natural product
description Fungal infections are a growing public health concern worldwide and the emergence of antifungal resistance has limited the number of therapeutic options. Therefore, developing novel strategies for identifying and developing new antifungal compounds is an active area of research in the pharmaceutical industry. In this study, we purified and characterized a trypsin protease inhibitor obtained from Yellow Bell Pepper (Capsicum annuum L.) seeds. The inhibitor not only showed potent and specific activity against the pathogenic fungus Candida albicans, but was also found to be non-toxic against human cells. Furthermore, this inhibitor is unique in that it also inhibits α-1,4-glucosidase, positioning it as one of the first plant-derived protease inhibitors with dual biological activity. This exciting discovery opens new avenues for the development of this inhibitor as a promising antifungal agent and highlights the potential of plant-derived protease inhibitors as a rich source for the discovery of novel multifunctional bioactive molecules.
publishDate 2023
dc.date.none.fl_str_mv 2
2023-01-01
2023
2023-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/281956
https://dx.doi.org/urn:doi:10.3390/pharmaceutics15030781
url https://ddd.uab.cat/record/281956
https://dx.doi.org/urn:doi:10.3390/pharmaceutics15030781
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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