Use and Safety of Remdesivir in Kidney Transplant Recipients With COVID-19

Buxeda, A; Arias-Cabrales, C; Perez-Saez, MJ; Cacho, J; Pelegrin, SC; Melilli, E; Aladren, MJ; Galeano, C; Lorenzo, I; Mazuecos, A; Saura, IM; Franco, A; Ruiz-Fuentes, MD; Sanchez-Camara, LA; Siverio, O; Martin, ML; Gonzalez-Garcia, E; Lopez, V; Martin-Moreno, PL; Moina, I; Berrio, EM; Moreso, F; Portoles, JM; Santana-Estupinan, R; Zarraga, S; Canal, C; Sanchez-Alvarez, E; Pascual, J; Crespo, M; Spanish Soc Nephrology COVID-19 Gr

Use and Safety of Remdesivir in Kidney Transplant Recipients With COVID-19

Introduction: Remdesivir has demonstrated antiviral activity against coronavirus, shortening the time to recovery in adults hospitalized with moderate/severe COVID-19. Severe adverse events such as acute kidney injury have been reported. Scant data are available on the use and safety of remdesivir i...

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Autores:	Buxeda, A, Arias-Cabrales, C, Perez-Saez, MJ, Cacho, J, Pelegrin, SC, Melilli, E, Aladren, MJ, Galeano, C, Lorenzo, I, Mazuecos, A, Saura, IM, Franco, A, Ruiz-Fuentes, MD, Sanchez-Camara, LA, Siverio, O, Martin, ML, Gonzalez-Garcia, E, Lopez, V, Martin-Moreno, PL, Moina, I, Berrio, EM, Moreso, F, Portoles, JM, Santana-Estupinan, R, Zarraga, S, Canal, C, Sanchez-Alvarez, E, Pascual, J, Crespo, M, Spanish Soc Nephrology COVID-19 Gr
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2021
País:	España
Institución:	Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
Repositorio:	r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
OAI Identifier:	oai:isabial.fundanetsuite.com:p7640
Acceso en línea:	https://isabial.portalinvestigacion.com/publicaciones7640
Access Level:	acceso abierto
Palabra clave:	acute kidney injury immunosuppression kidney transplantation remdesivir SARS-CoV2l

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spelling	Use and Safety of Remdesivir in Kidney Transplant Recipients With COVID-19Buxeda, AArias-Cabrales, CPerez-Saez, MJCacho, JPelegrin, SCMelilli, EAladren, MJGaleano, CLorenzo, IMazuecos, ASaura, IMFranco, ARuiz-Fuentes, MDSanchez-Camara, LASiverio, OMartin, MLGonzalez-Garcia, ELopez, VMartin-Moreno, PLMoina, IBerrio, EMMoreso, FPortoles, JMSantana-Estupinan, RZarraga, SCanal, CSanchez-Alvarez, EPascual, JCrespo, MSpanish Soc Nephrology COVID-19 Gracute kidney injuryimmunosuppressionkidney transplantationremdesivirSARS-CoV2lIntroduction: Remdesivir has demonstrated antiviral activity against coronavirus, shortening the time to recovery in adults hospitalized with moderate/severe COVID-19. Severe adverse events such as acute kidney injury have been reported. Scant data are available on the use and safety of remdesivir in kidney transplant recipients. Methods: We present a multicenter cohort study of 51 kidney transplant recipients with COVID-19 treated with remdesivir. Outcomes and safety were assessed. Results: Mean age at diagnosis was 60 years, with a median time since kidney transplant of 4.5 years. Mean time since admission to remdesivir was 2 days. Twenty-eight patients (54.9%) required mechanical ventilation (19 noninvasive). Mortality was 18.9% and markedly higher if aged >= 65 years (45% vs. 3.2% in younger patients). Acute kidney injury was present in 27.7% of patients, but was diagnosed in 50% before treatment. No patients required remdesivir discontinuation because of adverse events. We did not find significant hepatoxicity or systemic symptoms resulting from the drug. Conclusion: In our cohort of kidney transplant recipients, remdesivir was well tolerated and safe in renal and hepatic toxicity, but randomized trials are needed to assess its efficacy.ELSEVIER SCIENCE INC2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://isabial.portalinvestigacion.com/publicaciones7640Kidney International ReportsISSN: 24680249reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicanteinstname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)Inglésinfo:eu-repo/semantics/openAccessoai:isabial.fundanetsuite.com:p76402026-06-12T10:20:37Z
dc.title.none.fl_str_mv	Use and Safety of Remdesivir in Kidney Transplant Recipients With COVID-19
title	Use and Safety of Remdesivir in Kidney Transplant Recipients With COVID-19
spellingShingle	Use and Safety of Remdesivir in Kidney Transplant Recipients With COVID-19 Buxeda, A acute kidney injury immunosuppression kidney transplantation remdesivir SARS-CoV2l
title_short	Use and Safety of Remdesivir in Kidney Transplant Recipients With COVID-19
title_full	Use and Safety of Remdesivir in Kidney Transplant Recipients With COVID-19
title_fullStr	Use and Safety of Remdesivir in Kidney Transplant Recipients With COVID-19
title_full_unstemmed	Use and Safety of Remdesivir in Kidney Transplant Recipients With COVID-19
title_sort	Use and Safety of Remdesivir in Kidney Transplant Recipients With COVID-19
dc.creator.none.fl_str_mv	Buxeda, A Arias-Cabrales, C Perez-Saez, MJ Cacho, J Pelegrin, SC Melilli, E Aladren, MJ Galeano, C Lorenzo, I Mazuecos, A Saura, IM Franco, A Ruiz-Fuentes, MD Sanchez-Camara, LA Siverio, O Martin, ML Gonzalez-Garcia, E Lopez, V Martin-Moreno, PL Moina, I Berrio, EM Moreso, F Portoles, JM Santana-Estupinan, R Zarraga, S Canal, C Sanchez-Alvarez, E Pascual, J Crespo, M Spanish Soc Nephrology COVID-19 Gr
author	Buxeda, A
author_facet	Buxeda, A Arias-Cabrales, C Perez-Saez, MJ Cacho, J Pelegrin, SC Melilli, E Aladren, MJ Galeano, C Lorenzo, I Mazuecos, A Saura, IM Franco, A Ruiz-Fuentes, MD Sanchez-Camara, LA Siverio, O Martin, ML Gonzalez-Garcia, E Lopez, V Martin-Moreno, PL Moina, I Berrio, EM Moreso, F Portoles, JM Santana-Estupinan, R Zarraga, S Canal, C Sanchez-Alvarez, E Pascual, J Crespo, M Spanish Soc Nephrology COVID-19 Gr
author_role	author
author2	Arias-Cabrales, C Perez-Saez, MJ Cacho, J Pelegrin, SC Melilli, E Aladren, MJ Galeano, C Lorenzo, I Mazuecos, A Saura, IM Franco, A Ruiz-Fuentes, MD Sanchez-Camara, LA Siverio, O Martin, ML Gonzalez-Garcia, E Lopez, V Martin-Moreno, PL Moina, I Berrio, EM Moreso, F Portoles, JM Santana-Estupinan, R Zarraga, S Canal, C Sanchez-Alvarez, E Pascual, J Crespo, M Spanish Soc Nephrology COVID-19 Gr
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	acute kidney injury immunosuppression kidney transplantation remdesivir SARS-CoV2l
topic	acute kidney injury immunosuppression kidney transplantation remdesivir SARS-CoV2l
description	Introduction: Remdesivir has demonstrated antiviral activity against coronavirus, shortening the time to recovery in adults hospitalized with moderate/severe COVID-19. Severe adverse events such as acute kidney injury have been reported. Scant data are available on the use and safety of remdesivir in kidney transplant recipients. Methods: We present a multicenter cohort study of 51 kidney transplant recipients with COVID-19 treated with remdesivir. Outcomes and safety were assessed. Results: Mean age at diagnosis was 60 years, with a median time since kidney transplant of 4.5 years. Mean time since admission to remdesivir was 2 days. Twenty-eight patients (54.9%) required mechanical ventilation (19 noninvasive). Mortality was 18.9% and markedly higher if aged >= 65 years (45% vs. 3.2% in younger patients). Acute kidney injury was present in 27.7% of patients, but was diagnosed in 50% before treatment. No patients required remdesivir discontinuation because of adverse events. We did not find significant hepatoxicity or systemic symptoms resulting from the drug. Conclusion: In our cohort of kidney transplant recipients, remdesivir was well tolerated and safe in renal and hepatic toxicity, but randomized trials are needed to assess its efficacy.
publishDate	2021
dc.date.none.fl_str_mv	2021
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://isabial.portalinvestigacion.com/publicaciones7640
url	https://isabial.portalinvestigacion.com/publicaciones7640
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	ELSEVIER SCIENCE INC
publisher.none.fl_str_mv	ELSEVIER SCIENCE INC
dc.source.none.fl_str_mv	Kidney International Reports ISSN: 24680249 reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante instname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
instname_str	Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
reponame_str	r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
collection	r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15,812429

Use and Safety of Remdesivir in Kidney Transplant Recipients With COVID-19

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