Catalytic asymmetric alkylation of aryl heteroaryl ketones
Tertiary diarylmethanols are highly bioactive structural motifs. A new strategy to access chiral tertiary diarylmethanols through copper-catalyzed direct alkylation of (di)(hetero)aryl ketones by using Grignard reagents was developed. The low reactivity and the similarity of the enantiotopic faces o...
| Autores: | , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2015 |
| País: | España |
| Institución: | TECNALIA Research & Innovation |
| Repositorio: | TECNALIA Publications |
| Idioma: | inglés |
| OAI Identifier: | oai:dsp.tecnalia.com:11556/5296 |
| Acceso en línea: | https://hdl.handle.net/11556/5296 |
| Access Level: | acceso abierto |
| Palabra clave: | Addition reactions Alcohols Alkylation Asymmetric catalysis Diarylmethanols Synthetic methods Physical and Theoretical Chemistry Organic Chemistry |
| Sumario: | Tertiary diarylmethanols are highly bioactive structural motifs. A new strategy to access chiral tertiary diarylmethanols through copper-catalyzed direct alkylation of (di)(hetero)aryl ketones by using Grignard reagents was developed. The low reactivity and the similarity of the enantiotopic faces of bisaromatic ketones were partially overcome, which resulted in moderate to good yields and enantioselectivities. |
|---|