Influence of Polyols on the In Vitro Biodegradation and Bioactivity of 58S Bioactive Sol-Gel Coatings on AZ31B Magnesium Alloys

The mechanical qualities of AZ31B magnesium alloys make them a promising material for biodegradable metallic implants. However, rapid degradation limits the application of these alloys. In the present study, 58S bioactive glasses were synthesized using the sol-gel method and several polyols such as...

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Autores: Chandrasekar, Ashok Raja, Merino, Emilia, Pakseresht, Amirhossein, Galusek, Dusan, Durán, Alicia, Castro Martín, Yolanda
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/350311
Acceso en línea:http://hdl.handle.net/10261/350311
https://api.elsevier.com/content/abstract/scopus_id/85149757426
Access Level:acceso abierto
Palabra clave:58S sol-gel
bioactive glasses
biodegradable implants
magnesium alloy
polyols
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spelling Influence of Polyols on the In Vitro Biodegradation and Bioactivity of 58S Bioactive Sol-Gel Coatings on AZ31B Magnesium AlloysChandrasekar, Ashok RajaMerino, EmiliaPakseresht, AmirhosseinGalusek, DusanDurán, AliciaCastro Martín, Yolanda58S sol-gelbioactive glassesbiodegradable implantsmagnesium alloypolyolsThe mechanical qualities of AZ31B magnesium alloys make them a promising material for biodegradable metallic implants. However, rapid degradation limits the application of these alloys. In the present study, 58S bioactive glasses were synthesized using the sol-gel method and several polyols such as glycerol, ethylene glycol, and polyethylene glycol, were used to improve the sol stability and to control the degradation of AZ31B. The synthesized bioactive sols were dip-coated onto AZ31B substrates and then, characterized by various techniques such as scanning electron microscopy (SEM), X-ray diffraction (XRD) and electrochemical techniques (potentiodynamic and electrochemical impedance spectroscopy), among them. FTIR analysis confirmed the formation of a silica, calcium, and phosphate system and the XRD the amorphous nature of the 58S bioactive coatings obtained by sol-gel. The contact angle measurements confirmed that all the coatings were hydrophilic. The biodegradability response under physiological conditions (Hank's solution) was investigated for all the 58S bioactive glass coatings, observing a different behaviour depending on the polyols incorporated. Thus, for 58S PEG coating, an efficient control of the release of H2 gas was observed, and showing a pH control between 7.6 and 7.8 during all the tests. A marked apatite precipitation was also observed on the surface of the 58S PEG coating after the immersion test. Thus, the 58S PEG sol-gel coating is considered a promising alternative for biodegradable magnesium alloy-based medical implants.This project received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement no. 739566. The acknowledge financial support from MICINN under projects TED2021-131258B-I00.Peer reviewedMolecular Diversity Preservation International0000-0001-7089-129X0000-0002-8936-05330000-0001-6548-81130000-0001-5995-87800000-0002-0067-19340000-0001-5747-2162Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/350311https://api.elsevier.com/content/abstract/scopus_id/85149757426reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésPolymershttps://doi.org/10.3390/polym15051273Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3503112026-05-22T06:33:51Z
dc.title.none.fl_str_mv Influence of Polyols on the In Vitro Biodegradation and Bioactivity of 58S Bioactive Sol-Gel Coatings on AZ31B Magnesium Alloys
title Influence of Polyols on the In Vitro Biodegradation and Bioactivity of 58S Bioactive Sol-Gel Coatings on AZ31B Magnesium Alloys
spellingShingle Influence of Polyols on the In Vitro Biodegradation and Bioactivity of 58S Bioactive Sol-Gel Coatings on AZ31B Magnesium Alloys
Chandrasekar, Ashok Raja
58S sol-gel
bioactive glasses
biodegradable implants
magnesium alloy
polyols
title_short Influence of Polyols on the In Vitro Biodegradation and Bioactivity of 58S Bioactive Sol-Gel Coatings on AZ31B Magnesium Alloys
title_full Influence of Polyols on the In Vitro Biodegradation and Bioactivity of 58S Bioactive Sol-Gel Coatings on AZ31B Magnesium Alloys
title_fullStr Influence of Polyols on the In Vitro Biodegradation and Bioactivity of 58S Bioactive Sol-Gel Coatings on AZ31B Magnesium Alloys
title_full_unstemmed Influence of Polyols on the In Vitro Biodegradation and Bioactivity of 58S Bioactive Sol-Gel Coatings on AZ31B Magnesium Alloys
title_sort Influence of Polyols on the In Vitro Biodegradation and Bioactivity of 58S Bioactive Sol-Gel Coatings on AZ31B Magnesium Alloys
dc.creator.none.fl_str_mv Chandrasekar, Ashok Raja
Merino, Emilia
Pakseresht, Amirhossein
Galusek, Dusan
Durán, Alicia
Castro Martín, Yolanda
author Chandrasekar, Ashok Raja
author_facet Chandrasekar, Ashok Raja
Merino, Emilia
Pakseresht, Amirhossein
Galusek, Dusan
Durán, Alicia
Castro Martín, Yolanda
author_role author
author2 Merino, Emilia
Pakseresht, Amirhossein
Galusek, Dusan
Durán, Alicia
Castro Martín, Yolanda
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv 0000-0001-7089-129X
0000-0002-8936-0533
0000-0001-6548-8113
0000-0001-5995-8780
0000-0002-0067-1934
0000-0001-5747-2162
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv 58S sol-gel
bioactive glasses
biodegradable implants
magnesium alloy
polyols
topic 58S sol-gel
bioactive glasses
biodegradable implants
magnesium alloy
polyols
description The mechanical qualities of AZ31B magnesium alloys make them a promising material for biodegradable metallic implants. However, rapid degradation limits the application of these alloys. In the present study, 58S bioactive glasses were synthesized using the sol-gel method and several polyols such as glycerol, ethylene glycol, and polyethylene glycol, were used to improve the sol stability and to control the degradation of AZ31B. The synthesized bioactive sols were dip-coated onto AZ31B substrates and then, characterized by various techniques such as scanning electron microscopy (SEM), X-ray diffraction (XRD) and electrochemical techniques (potentiodynamic and electrochemical impedance spectroscopy), among them. FTIR analysis confirmed the formation of a silica, calcium, and phosphate system and the XRD the amorphous nature of the 58S bioactive coatings obtained by sol-gel. The contact angle measurements confirmed that all the coatings were hydrophilic. The biodegradability response under physiological conditions (Hank's solution) was investigated for all the 58S bioactive glass coatings, observing a different behaviour depending on the polyols incorporated. Thus, for 58S PEG coating, an efficient control of the release of H2 gas was observed, and showing a pH control between 7.6 and 7.8 during all the tests. A marked apatite precipitation was also observed on the surface of the 58S PEG coating after the immersion test. Thus, the 58S PEG sol-gel coating is considered a promising alternative for biodegradable magnesium alloy-based medical implants.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/350311
https://api.elsevier.com/content/abstract/scopus_id/85149757426
url http://hdl.handle.net/10261/350311
https://api.elsevier.com/content/abstract/scopus_id/85149757426
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Polymers
https://doi.org/10.3390/polym15051273
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Molecular Diversity Preservation International
publisher.none.fl_str_mv Molecular Diversity Preservation International
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812455

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