The role of endothelial glycocalyx in health and disease

The endothelium is the largest organ in the body and recent studies have shown that the endothelial glycocalyx (eGCX) plays a major role in health and disease states. The integrity of eGCX is vital for homoeostasis and disruption of its structure and function plays a major role in several pathologic...

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Detalles Bibliográficos
Autores: Yilmaz, Onur, Afsar, Baris, Ortiz Arduán, Alberto, Kanbay, Mehmet
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/691207
Acceso en línea:http://hdl.handle.net/10486/691207
https://dx.doi.org/10.1093/ckj/sfz042
Access Level:acceso abierto
Palabra clave:Chronic kidney disease
Diabetes mellitus
Endothelial glycocalyx
Medicina
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spelling The role of endothelial glycocalyx in health and diseaseYilmaz, OnurAfsar, BarisOrtiz Arduán, AlbertoKanbay, MehmetChronic kidney diseaseDiabetes mellitusEndothelial glycocalyxMedicinaThe endothelium is the largest organ in the body and recent studies have shown that the endothelial glycocalyx (eGCX) plays a major role in health and disease states. The integrity of eGCX is vital for homoeostasis and disruption of its structure and function plays a major role in several pathologic conditions. An increased understanding of the numerous pathophysiological roles of eGCX may lead to the development of potential surrogate markers for endothelial injury or novel therapeutic targets. This review provides a state-of-the-art update on the structure and function of the eGCX, emphasizing the current understanding of interorgan crosstalk between the eGCX and other organs that might also contribute to the pathogenesis of kidney diseasesM.K. gratefully acknowledges use of the services and facilities of the Koc University Research Center for Translational Medicine, funded by the Republic of Turkey, Ministry of DevelopmentOxford University Press on behalf of ERA-EDTADepartamento de MedicinaFacultad de Medicina20192019-04-23research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/691207https://dx.doi.org/10.1093/ckj/sfz042reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/6912072026-06-23T12:46:27Z
dc.title.none.fl_str_mv The role of endothelial glycocalyx in health and disease
title The role of endothelial glycocalyx in health and disease
spellingShingle The role of endothelial glycocalyx in health and disease
Yilmaz, Onur
Chronic kidney disease
Diabetes mellitus
Endothelial glycocalyx
Medicina
title_short The role of endothelial glycocalyx in health and disease
title_full The role of endothelial glycocalyx in health and disease
title_fullStr The role of endothelial glycocalyx in health and disease
title_full_unstemmed The role of endothelial glycocalyx in health and disease
title_sort The role of endothelial glycocalyx in health and disease
dc.creator.none.fl_str_mv Yilmaz, Onur
Afsar, Baris
Ortiz Arduán, Alberto
Kanbay, Mehmet
author Yilmaz, Onur
author_facet Yilmaz, Onur
Afsar, Baris
Ortiz Arduán, Alberto
Kanbay, Mehmet
author_role author
author2 Afsar, Baris
Ortiz Arduán, Alberto
Kanbay, Mehmet
author2_role author
author
author
dc.contributor.none.fl_str_mv Departamento de Medicina
Facultad de Medicina
dc.subject.none.fl_str_mv Chronic kidney disease
Diabetes mellitus
Endothelial glycocalyx
Medicina
topic Chronic kidney disease
Diabetes mellitus
Endothelial glycocalyx
Medicina
description The endothelium is the largest organ in the body and recent studies have shown that the endothelial glycocalyx (eGCX) plays a major role in health and disease states. The integrity of eGCX is vital for homoeostasis and disruption of its structure and function plays a major role in several pathologic conditions. An increased understanding of the numerous pathophysiological roles of eGCX may lead to the development of potential surrogate markers for endothelial injury or novel therapeutic targets. This review provides a state-of-the-art update on the structure and function of the eGCX, emphasizing the current understanding of interorgan crosstalk between the eGCX and other organs that might also contribute to the pathogenesis of kidney diseases
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-04-23
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/691207
https://dx.doi.org/10.1093/ckj/sfz042
url http://hdl.handle.net/10486/691207
https://dx.doi.org/10.1093/ckj/sfz042
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Oxford University Press on behalf of ERA-EDTA
publisher.none.fl_str_mv Oxford University Press on behalf of ERA-EDTA
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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