Paternal preconception folate intake in relation to gestational age at delivery and birthweight of newborns conceived through assisted reproduction
Research question Studies in rodents have shown that paternal folate intake prior to conception is associated with pregnancy and offspring outcomes. The aim of this study was to assess whether those associations might apply to humans as well. Design Between 2007 and 2017, the study prospectively ana...
| Autores: | , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2019 |
| País: | España |
| Institución: | Universidad de Navarra |
| Repositorio: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | inglés |
| OAI Identifier: | oai:dadun.unav.edu:10171/69144 |
| Acceso en línea: | https://hdl.handle.net/10171/69144 |
| Access Level: | acceso abierto |
| Palabra clave: | Gestational age Maternal folate Offspring birthweight Paternal folate |
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Paternal preconception folate intake in relation to gestational age at delivery and birthweight of newborns conceived through assisted reproductionMartín-Calvo, N. (Nerea)|||/items/c07b9283-4100-4920-84e6-8640d715d701Mínguez-Alarcón, L. (Lidia)|||/items/c9980b5f-5c45-4659-8f9f-58bed4fe5d2fGaskins, A.J. (Audrey J.)|||/items/be76107c-53c7-4097-869e-2cc55bb677a8Nassan, F.L. (Feiby L.)|||/items/3a02f533-f92d-43a2-b476-387f089fd85fWilliams, P.L. (Paige L.)|||/items/4ddb97b8-6701-46d3-841e-8f3b5d6eda17Souter, I. (Irene)|||/items/a45c88e9-b8e7-4df4-a8ef-4f66f097fe23Hauser, R. (Russ)|||/items/c2f05f55-d9fc-4db6-91ea-bcb29c315fb2Chavarro, J.E. (Jorge E.)|||/items/9f4d388e-f899-479f-b4e3-2dcaaad34622Gestational ageMaternal folateOffspring birthweightPaternal folateResearch question Studies in rodents have shown that paternal folate intake prior to conception is associated with pregnancy and offspring outcomes. The aim of this study was to assess whether those associations might apply to humans as well. Design Between 2007 and 2017, the study prospectively analysed data from 108 couples participating in a preconception cohort of couples undergoing fertility treatment using their own gametes, whose treatment resulted in 113 pregnancies during the course of the study. Paternal and maternal preconception folate intake was assessed using a validated food frequency questionnaire. Linear mixed models were used to assess whether paternal preconception folate intake was associated with gestational age at delivery and gestational age-specific birthweight, while accounting for correlated data and potential confounders. Results In a multivariable-adjusted model, a 400 μg/day increase in preconception paternal folate intake was associated with a 2.6-day longer gestation (95% confidence interval 0.8–4.3) after adjusting for potential confounders, including maternal folate intake. Similar associations were found for folate from food and supplements. Maternal folate intake was not associated with gestational age at delivery. Neither paternal nor maternal folate intake was associated with gestational-age-specific birthweight. Conclusions Higher paternal preconception folate intake was associated with slightly longer gestation among live births achieved through assisted reproduction. The results suggest that preconception exposures of the father may have an impact on the health of his offspring, and therefore that preconception care should shift from a woman-centric to a couple-based approach.ElsevierDadun. Depósito Académico Digital Universidad de Navarra20242024-02-2020192019-01-0120192019-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/69144reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/691442026-06-21T12:47:57Z |
| dc.title.none.fl_str_mv |
Paternal preconception folate intake in relation to gestational age at delivery and birthweight of newborns conceived through assisted reproduction |
| title |
Paternal preconception folate intake in relation to gestational age at delivery and birthweight of newborns conceived through assisted reproduction |
| spellingShingle |
Paternal preconception folate intake in relation to gestational age at delivery and birthweight of newborns conceived through assisted reproduction Martín-Calvo, N. (Nerea)|||/items/c07b9283-4100-4920-84e6-8640d715d701 Gestational age Maternal folate Offspring birthweight Paternal folate |
| title_short |
Paternal preconception folate intake in relation to gestational age at delivery and birthweight of newborns conceived through assisted reproduction |
| title_full |
Paternal preconception folate intake in relation to gestational age at delivery and birthweight of newborns conceived through assisted reproduction |
| title_fullStr |
Paternal preconception folate intake in relation to gestational age at delivery and birthweight of newborns conceived through assisted reproduction |
| title_full_unstemmed |
Paternal preconception folate intake in relation to gestational age at delivery and birthweight of newborns conceived through assisted reproduction |
| title_sort |
Paternal preconception folate intake in relation to gestational age at delivery and birthweight of newborns conceived through assisted reproduction |
| dc.creator.none.fl_str_mv |
Martín-Calvo, N. (Nerea)|||/items/c07b9283-4100-4920-84e6-8640d715d701 Mínguez-Alarcón, L. (Lidia)|||/items/c9980b5f-5c45-4659-8f9f-58bed4fe5d2f Gaskins, A.J. (Audrey J.)|||/items/be76107c-53c7-4097-869e-2cc55bb677a8 Nassan, F.L. (Feiby L.)|||/items/3a02f533-f92d-43a2-b476-387f089fd85f Williams, P.L. (Paige L.)|||/items/4ddb97b8-6701-46d3-841e-8f3b5d6eda17 Souter, I. (Irene)|||/items/a45c88e9-b8e7-4df4-a8ef-4f66f097fe23 Hauser, R. (Russ)|||/items/c2f05f55-d9fc-4db6-91ea-bcb29c315fb2 Chavarro, J.E. (Jorge E.)|||/items/9f4d388e-f899-479f-b4e3-2dcaaad34622 |
| author |
Martín-Calvo, N. (Nerea)|||/items/c07b9283-4100-4920-84e6-8640d715d701 |
| author_facet |
Martín-Calvo, N. (Nerea)|||/items/c07b9283-4100-4920-84e6-8640d715d701 Mínguez-Alarcón, L. (Lidia)|||/items/c9980b5f-5c45-4659-8f9f-58bed4fe5d2f Gaskins, A.J. (Audrey J.)|||/items/be76107c-53c7-4097-869e-2cc55bb677a8 Nassan, F.L. (Feiby L.)|||/items/3a02f533-f92d-43a2-b476-387f089fd85f Williams, P.L. (Paige L.)|||/items/4ddb97b8-6701-46d3-841e-8f3b5d6eda17 Souter, I. (Irene)|||/items/a45c88e9-b8e7-4df4-a8ef-4f66f097fe23 Hauser, R. (Russ)|||/items/c2f05f55-d9fc-4db6-91ea-bcb29c315fb2 Chavarro, J.E. (Jorge E.)|||/items/9f4d388e-f899-479f-b4e3-2dcaaad34622 |
| author_role |
author |
| author2 |
Mínguez-Alarcón, L. (Lidia)|||/items/c9980b5f-5c45-4659-8f9f-58bed4fe5d2f Gaskins, A.J. (Audrey J.)|||/items/be76107c-53c7-4097-869e-2cc55bb677a8 Nassan, F.L. (Feiby L.)|||/items/3a02f533-f92d-43a2-b476-387f089fd85f Williams, P.L. (Paige L.)|||/items/4ddb97b8-6701-46d3-841e-8f3b5d6eda17 Souter, I. (Irene)|||/items/a45c88e9-b8e7-4df4-a8ef-4f66f097fe23 Hauser, R. (Russ)|||/items/c2f05f55-d9fc-4db6-91ea-bcb29c315fb2 Chavarro, J.E. (Jorge E.)|||/items/9f4d388e-f899-479f-b4e3-2dcaaad34622 |
| author2_role |
author author author author author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
Gestational age Maternal folate Offspring birthweight Paternal folate |
| topic |
Gestational age Maternal folate Offspring birthweight Paternal folate |
| description |
Research question Studies in rodents have shown that paternal folate intake prior to conception is associated with pregnancy and offspring outcomes. The aim of this study was to assess whether those associations might apply to humans as well. Design Between 2007 and 2017, the study prospectively analysed data from 108 couples participating in a preconception cohort of couples undergoing fertility treatment using their own gametes, whose treatment resulted in 113 pregnancies during the course of the study. Paternal and maternal preconception folate intake was assessed using a validated food frequency questionnaire. Linear mixed models were used to assess whether paternal preconception folate intake was associated with gestational age at delivery and gestational age-specific birthweight, while accounting for correlated data and potential confounders. Results In a multivariable-adjusted model, a 400 μg/day increase in preconception paternal folate intake was associated with a 2.6-day longer gestation (95% confidence interval 0.8–4.3) after adjusting for potential confounders, including maternal folate intake. Similar associations were found for folate from food and supplements. Maternal folate intake was not associated with gestational age at delivery. Neither paternal nor maternal folate intake was associated with gestational-age-specific birthweight. Conclusions Higher paternal preconception folate intake was associated with slightly longer gestation among live births achieved through assisted reproduction. The results suggest that preconception exposures of the father may have an impact on the health of his offspring, and therefore that preconception care should shift from a woman-centric to a couple-based approach. |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2019 2019-01-01 2019 2019-01-01 2024 2024-02-20 |
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journal article http://purl.org/coar/resource_type/c_6501 |
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info:eu-repo/semantics/article |
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article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10171/69144 |
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https://hdl.handle.net/10171/69144 |
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Inglés eng |
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Inglés |
| language |
eng |
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open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
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Elsevier |
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Elsevier |
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reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra |
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Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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