Predictors of Severe Sepsis among Patients Hospitalized for Community-Acquired Pneumonia

Background Severe sepsis, may be present on hospital arrival in approximately one-third of patients with community-acquired pneumonia (CAP). Objective To determine the host characteristics and micro-organisms associated with severe sepsis in patients hospitalized with CAP. Results We performed a pro...

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Detalhes bibliográficos
Autores: Montull, Beatriz, Menéndez, Rosario, Torres, Antoni, Reyes, Soledad, Méndez, Raúl, Alfageme Michavila, Inmaculada, Ruiz Manzano, Juan
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2016
País:España
Recursos:Universidad de Sevilla (US)
Repositório:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/125198
Acesso em linha:https://hdl.handle.net/11441/125198
https://doi.org/10.1371/journal.pone.0145929
Access Level:Acceso aberto
Palavra-chave:Sepsis
Microbiological studies
Severe sepsis
Community acquired pneumonia
CAP
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spelling Predictors of Severe Sepsis among Patients Hospitalized for Community-Acquired PneumoniaMontull, BeatrizMenéndez, RosarioTorres, AntoniReyes, SoledadMéndez, RaúlAlfageme Michavila, InmaculadaRuiz Manzano, JuanSepsisMicrobiological studiesSevere sepsisCommunity acquired pneumoniaCAPBackground Severe sepsis, may be present on hospital arrival in approximately one-third of patients with community-acquired pneumonia (CAP). Objective To determine the host characteristics and micro-organisms associated with severe sepsis in patients hospitalized with CAP. Results We performed a prospective multicenter cohort study in 13 Spanish hospital, on 4070 hospitalized CAP patients, 1529 of whom (37.6%) presented with severe sepsis. Severe sepsis CAP was independently associated with older age (>65 years), alcohol abuse (OR, 1.31; 95% CI, 1.07–1.61), chronic obstructive pulmonary disease (COPD) (OR, 1.75; 95% CI, 1.50–2.04) and renal disease (OR, 1.57; 95% CI, 1.21–2.03), whereas prior antibiotic treatment was a protective factor (OR, 0.62; 95% CI, 0.52–0.73). Bacteremia (OR, 1.37; 95% CI, 1.05–1.79), S pneumoniae (OR, 1.59; 95% CI, 1.31–1.95) and mixed microbial etiology (OR, 1.65; 95% CI, 1.10–2.49) were associated with severe sepsis CAP. Conclusions CAP patients with COPD, renal disease and alcohol abuse, as well as those with CAP due to S pneumonia or mixed micro-organisms are more likely to present to the hospital with severe sepsis.PII (Programme of research of SEPAR) in respiratory infectionCIBERES (Centro de investigación en red de enfermedades respiratorias) an initiative of ISCIII (Instituto de Salud Carlos III)Beca SEPAR (Sociedad Española de Neumología y Cirugía torácica) (2006/0237)Beca de la Consellería Sanitat Comunidad Valenciana (2007/ 0059)Public Library of ScienceMedicina2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/125198https://doi.org/10.1371/journal.pone.0145929reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésPLoS ONE, 11 (1), art.n.e0145929.2006/02372007/0059https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0145929info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1251982026-06-17T12:51:07Z
dc.title.none.fl_str_mv Predictors of Severe Sepsis among Patients Hospitalized for Community-Acquired Pneumonia
title Predictors of Severe Sepsis among Patients Hospitalized for Community-Acquired Pneumonia
spellingShingle Predictors of Severe Sepsis among Patients Hospitalized for Community-Acquired Pneumonia
Montull, Beatriz
Sepsis
Microbiological studies
Severe sepsis
Community acquired pneumonia
CAP
title_short Predictors of Severe Sepsis among Patients Hospitalized for Community-Acquired Pneumonia
title_full Predictors of Severe Sepsis among Patients Hospitalized for Community-Acquired Pneumonia
title_fullStr Predictors of Severe Sepsis among Patients Hospitalized for Community-Acquired Pneumonia
title_full_unstemmed Predictors of Severe Sepsis among Patients Hospitalized for Community-Acquired Pneumonia
title_sort Predictors of Severe Sepsis among Patients Hospitalized for Community-Acquired Pneumonia
dc.creator.none.fl_str_mv Montull, Beatriz
Menéndez, Rosario
Torres, Antoni
Reyes, Soledad
Méndez, Raúl
Alfageme Michavila, Inmaculada
Ruiz Manzano, Juan
author Montull, Beatriz
author_facet Montull, Beatriz
Menéndez, Rosario
Torres, Antoni
Reyes, Soledad
Méndez, Raúl
Alfageme Michavila, Inmaculada
Ruiz Manzano, Juan
author_role author
author2 Menéndez, Rosario
Torres, Antoni
Reyes, Soledad
Méndez, Raúl
Alfageme Michavila, Inmaculada
Ruiz Manzano, Juan
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Medicina
dc.subject.none.fl_str_mv Sepsis
Microbiological studies
Severe sepsis
Community acquired pneumonia
CAP
topic Sepsis
Microbiological studies
Severe sepsis
Community acquired pneumonia
CAP
description Background Severe sepsis, may be present on hospital arrival in approximately one-third of patients with community-acquired pneumonia (CAP). Objective To determine the host characteristics and micro-organisms associated with severe sepsis in patients hospitalized with CAP. Results We performed a prospective multicenter cohort study in 13 Spanish hospital, on 4070 hospitalized CAP patients, 1529 of whom (37.6%) presented with severe sepsis. Severe sepsis CAP was independently associated with older age (>65 years), alcohol abuse (OR, 1.31; 95% CI, 1.07–1.61), chronic obstructive pulmonary disease (COPD) (OR, 1.75; 95% CI, 1.50–2.04) and renal disease (OR, 1.57; 95% CI, 1.21–2.03), whereas prior antibiotic treatment was a protective factor (OR, 0.62; 95% CI, 0.52–0.73). Bacteremia (OR, 1.37; 95% CI, 1.05–1.79), S pneumoniae (OR, 1.59; 95% CI, 1.31–1.95) and mixed microbial etiology (OR, 1.65; 95% CI, 1.10–2.49) were associated with severe sepsis CAP. Conclusions CAP patients with COPD, renal disease and alcohol abuse, as well as those with CAP due to S pneumonia or mixed micro-organisms are more likely to present to the hospital with severe sepsis.
publishDate 2016
dc.date.none.fl_str_mv 2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/125198
https://doi.org/10.1371/journal.pone.0145929
url https://hdl.handle.net/11441/125198
https://doi.org/10.1371/journal.pone.0145929
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv PLoS ONE, 11 (1), art.n.e0145929.
2006/0237
2007/0059
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0145929
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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