Respiratory Polygraphy Patterns and Risk of Recurrent Cardiovascular Events in Patients With Acute Coronary Syndrome
Introduction: Obstructive sleep apnea (OSA) severity is based on the apnea-hypopnea index (AHI). The AHI is a simplistic measure that is inadequate for capturing disease severity and its consequences in cardiovascular diseases (CVDs). Deleterious effects of OSA have been suggested to influence the p...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2022 |
| País: | España |
| Recursos: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:10459.1/83694 |
| Acesso em linha: | https://doi.org/10.3389/fmed.2022.870906 http://hdl.handle.net/10459.1/83694 |
| Access Level: | acceso abierto |
| Palavra-chave: | Acute coronary syndrome Cardiovascular disease Obstructive sleep apnea Precision medicine Respiratory polygraphy |
| id |
ES_3b32aaddfbdb84fbbcfbf887ae93639a |
|---|---|
| oai_identifier_str |
oai:recercat.cat:10459.1/83694 |
| network_acronym_str |
ES |
| network_name_str |
España |
| repository_id_str |
|
| dc.title.none.fl_str_mv |
Respiratory Polygraphy Patterns and Risk of Recurrent Cardiovascular Events in Patients With Acute Coronary Syndrome |
| title |
Respiratory Polygraphy Patterns and Risk of Recurrent Cardiovascular Events in Patients With Acute Coronary Syndrome |
| spellingShingle |
Respiratory Polygraphy Patterns and Risk of Recurrent Cardiovascular Events in Patients With Acute Coronary Syndrome Zapater, Andrea Acute coronary syndrome Cardiovascular disease Obstructive sleep apnea Precision medicine Respiratory polygraphy |
| title_short |
Respiratory Polygraphy Patterns and Risk of Recurrent Cardiovascular Events in Patients With Acute Coronary Syndrome |
| title_full |
Respiratory Polygraphy Patterns and Risk of Recurrent Cardiovascular Events in Patients With Acute Coronary Syndrome |
| title_fullStr |
Respiratory Polygraphy Patterns and Risk of Recurrent Cardiovascular Events in Patients With Acute Coronary Syndrome |
| title_full_unstemmed |
Respiratory Polygraphy Patterns and Risk of Recurrent Cardiovascular Events in Patients With Acute Coronary Syndrome |
| title_sort |
Respiratory Polygraphy Patterns and Risk of Recurrent Cardiovascular Events in Patients With Acute Coronary Syndrome |
| dc.creator.none.fl_str_mv |
Zapater, Andrea Solelhac, Geoffroy Sánchez de la Torre, Alicia Gracia-Lavedan, Esther Benítez, Iván Torres, Gerard Batlle Garcia, Jordi de Haba Rubio, José Berger, Mathieu Abad, Jorge Durán-Cantolla, Joaquín Urrutia, Amaia Mediano, Olga Masdeu, María José Ordax-Carbajo, Estrella Masa, Juan Fernando Peña, Mónica de la Mayós Pérez, Mercè Coloma, Ramón Montserrat, Josep Maria Chiner, Eusebi Minguez Roure, Olga Pascual, Lydia Cortijo, Anunciación Martínez, Dolores Dalmases, Mireia Lee, Chi-Hang McEvoy, R. Doug Barbé Illa, Ferran Heinzer, Raphael Sánchez de la Torre, Manuel |
| author |
Zapater, Andrea |
| author_facet |
Zapater, Andrea Solelhac, Geoffroy Sánchez de la Torre, Alicia Gracia-Lavedan, Esther Benítez, Iván Torres, Gerard Batlle Garcia, Jordi de Haba Rubio, José Berger, Mathieu Abad, Jorge Durán-Cantolla, Joaquín Urrutia, Amaia Mediano, Olga Masdeu, María José Ordax-Carbajo, Estrella Masa, Juan Fernando Peña, Mónica de la Mayós Pérez, Mercè Coloma, Ramón Montserrat, Josep Maria Chiner, Eusebi Minguez Roure, Olga Pascual, Lydia Cortijo, Anunciación Martínez, Dolores Dalmases, Mireia Lee, Chi-Hang McEvoy, R. Doug Barbé Illa, Ferran Heinzer, Raphael Sánchez de la Torre, Manuel |
| author_role |
author |
| author2 |
Solelhac, Geoffroy Sánchez de la Torre, Alicia Gracia-Lavedan, Esther Benítez, Iván Torres, Gerard Batlle Garcia, Jordi de Haba Rubio, José Berger, Mathieu Abad, Jorge Durán-Cantolla, Joaquín Urrutia, Amaia Mediano, Olga Masdeu, María José Ordax-Carbajo, Estrella Masa, Juan Fernando Peña, Mónica de la Mayós Pérez, Mercè Coloma, Ramón Montserrat, Josep Maria Chiner, Eusebi Minguez Roure, Olga Pascual, Lydia Cortijo, Anunciación Martínez, Dolores Dalmases, Mireia Lee, Chi-Hang McEvoy, R. Doug Barbé Illa, Ferran Heinzer, Raphael Sánchez de la Torre, Manuel |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Acute coronary syndrome Cardiovascular disease Obstructive sleep apnea Precision medicine Respiratory polygraphy |
| topic |
Acute coronary syndrome Cardiovascular disease Obstructive sleep apnea Precision medicine Respiratory polygraphy |
| description |
Introduction: Obstructive sleep apnea (OSA) severity is based on the apnea-hypopnea index (AHI). The AHI is a simplistic measure that is inadequate for capturing disease severity and its consequences in cardiovascular diseases (CVDs). Deleterious effects of OSA have been suggested to influence the prognosis of specific endotypes of patients with acute coronary syndrome (ACS). We aim to identify respiratory polygraphy (RP) patterns that contribute to identifying the risk of recurrent cardiovascular events in patients with ACS. Methods: Post hoc analysis of the ISAACC study, including 723 patients admitted for a first ACS (NCT01335087) in which RP was performed. To identify specific RP patterns, a principal component analysis (PCA) was performed using six RP parameters: AHI, oxygen desaturation index, mean and minimum oxygen saturation (SaO2), average duration of events and percentage of time with SaO2 < 90%. An independent HypnoLaus population-based cohort was used to validate the RP components. Results: From the ISAACC study, PCA showed that two RP components accounted for 70% of the variance in the RP data. These components were validated in the HypnoLaus cohort, with two similar RP components that explained 71.3% of the variance in the RP data. The first component (component 1) was mainly characterized by low mean SaO2 and obstructive respiratory events with severe desaturation, and the second component (component 2) was characterized by high mean SaO2 and long-duration obstructive respiratory events without severe desaturation. In the ISAACC cohort, component 2 was associated with an increased risk of recurrent cardiovascular events in the third tertile with an adjusted hazard ratio (95% CI) of 2.44 (1.07 to 5.56; p-value = 0.03) compared to first tertile. For component 1, no significant association was found for the risk of recurrent cardiovascular events. Conclusion: A RP component, mainly characterized by intermittent hypoxemia, is associated with a high risk of recurrent cardiovascular events in patients without previous CVD who have suffered a first ACS. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022 2022 2022 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://doi.org/10.3389/fmed.2022.870906 http://hdl.handle.net/10459.1/83694 http://hdl.handle.net/10459.1/83694 |
| url |
https://doi.org/10.3389/fmed.2022.870906 http://hdl.handle.net/10459.1/83694 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Reproducció del document publicat a: https://doi.org/10.3389/fmed.2022.870906 Frontiers in Medicine, 2022, vol. 9 |
| dc.rights.none.fl_str_mv |
cc-by (c) Authors, 2022 info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0/ |
| rights_invalid_str_mv |
cc-by (c) Authors, 2022 http://creativecommons.org/licenses/by/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Frontiers Media |
| publisher.none.fl_str_mv |
Frontiers Media |
| dc.source.none.fl_str_mv |
reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str |
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| reponame_str |
Recercat. Dipósit de la Recerca de Catalunya |
| collection |
Recercat. Dipósit de la Recerca de Catalunya |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1869406291073433600 |
| spelling |
Respiratory Polygraphy Patterns and Risk of Recurrent Cardiovascular Events in Patients With Acute Coronary SyndromeZapater, AndreaSolelhac, GeoffroySánchez de la Torre, AliciaGracia-Lavedan, EstherBenítez, IvánTorres, GerardBatlle Garcia, Jordi deHaba Rubio, JoséBerger, MathieuAbad, JorgeDurán-Cantolla, JoaquínUrrutia, AmaiaMediano, OlgaMasdeu, María JoséOrdax-Carbajo, EstrellaMasa, Juan FernandoPeña, Mónica de laMayós Pérez, MercèColoma, RamónMontserrat, Josep MariaChiner, EusebiMinguez Roure, OlgaPascual, LydiaCortijo, AnunciaciónMartínez, DoloresDalmases, MireiaLee, Chi-HangMcEvoy, R. DougBarbé Illa, FerranHeinzer, RaphaelSánchez de la Torre, ManuelAcute coronary syndromeCardiovascular diseaseObstructive sleep apneaPrecision medicineRespiratory polygraphyIntroduction: Obstructive sleep apnea (OSA) severity is based on the apnea-hypopnea index (AHI). The AHI is a simplistic measure that is inadequate for capturing disease severity and its consequences in cardiovascular diseases (CVDs). Deleterious effects of OSA have been suggested to influence the prognosis of specific endotypes of patients with acute coronary syndrome (ACS). We aim to identify respiratory polygraphy (RP) patterns that contribute to identifying the risk of recurrent cardiovascular events in patients with ACS. Methods: Post hoc analysis of the ISAACC study, including 723 patients admitted for a first ACS (NCT01335087) in which RP was performed. To identify specific RP patterns, a principal component analysis (PCA) was performed using six RP parameters: AHI, oxygen desaturation index, mean and minimum oxygen saturation (SaO2), average duration of events and percentage of time with SaO2 < 90%. An independent HypnoLaus population-based cohort was used to validate the RP components. Results: From the ISAACC study, PCA showed that two RP components accounted for 70% of the variance in the RP data. These components were validated in the HypnoLaus cohort, with two similar RP components that explained 71.3% of the variance in the RP data. The first component (component 1) was mainly characterized by low mean SaO2 and obstructive respiratory events with severe desaturation, and the second component (component 2) was characterized by high mean SaO2 and long-duration obstructive respiratory events without severe desaturation. In the ISAACC cohort, component 2 was associated with an increased risk of recurrent cardiovascular events in the third tertile with an adjusted hazard ratio (95% CI) of 2.44 (1.07 to 5.56; p-value = 0.03) compared to first tertile. For component 1, no significant association was found for the risk of recurrent cardiovascular events. Conclusion: A RP component, mainly characterized by intermittent hypoxemia, is associated with a high risk of recurrent cardiovascular events in patients without previous CVD who have suffered a first ACS.Instituto de Salud Carlos III (ISCIII; PI10/02763, PI10/02745, PI18/00449, and PI19/00907), co-funded by FEDER, “Una manera de hacer europa,” IRBLleida – Fundació Pifarré, CERCA Programme/Generalitat de Catalunya, SEPAR, ResMed Ltd. (Australia), Esteve-Teijin (Spain), Oxigen Salud (Spain), Associació Lleidatana de Respiratori (ALLER), and Sociedad Española de Sueño (SES). AZ is the recipient of a predoctoral fellowship “Ajuts 2021 de Promoció de la Recerca en Salut-9a edició” from IRBLleida/Diputació de Lleida. JD acknowledges receiving financial support from ISCIII (Miguel Servet 2019: CP19/00108), co-funded by the European Social Fund (ESF), “Investing in your future.” MS-d-l-T has received financial support from a “Ramón y Cajal” grant (RYC2019-027831-I) from the “Ministerio de Ciencia e Innovación – Agencia Estatal de Investigación” co-funded by the European Social Fund (ESF)/“Investing in your future.” FB received funding from from ResMed (an Australian company that develops products related to sleep apnea), the Health Research Fund, the Spanish Ministry of Health, the Spanish Respiratory Society, the Catalonian Cardiology Society, Esteve-Teijin (Spain), Oxigen Salud (Spain), and ALLER. The funders were not involved in the study design, collection, analysis, interpretation of data, the writing of this article, or the decision to submit it for publication.Frontiers Media202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://doi.org/10.3389/fmed.2022.870906http://hdl.handle.net/10459.1/83694http://hdl.handle.net/10459.1/83694reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3389/fmed.2022.870906Frontiers in Medicine, 2022, vol. 9cc-by (c) Authors, 2022info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/oai:recercat.cat:10459.1/836942026-05-29T05:05:01Z |
| score |
15,811543 |