Evaluation of the efficacy of an antioxidant combination for the modulation of metabolic, endocrine, and clinical parameters in patients with polycystic ovary syndrome

Objective: to evaluate the efficacy of dietary supplementation with a combination of antioxidants (lipoic acid, N-acetylcysteine, vitamin B6, and S-adenosyl-l-methionine) for the modulation of metabolic, endocrine, and clinical parameters in comparison with oral contraception in non-diabetic women n...

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Autores: Pingarrón Santofimia, Carmen, Poyo Torcal, Silvia, López Verdú, Helena, Henríquez Linares, Alexandra, Calvente Aguilar, Virginia, Terol Sánchez, Pablo, Martínez García, María Sol, Lafunte González, Pilar
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universidad Europea (UEM)
Repositorio:ABACUS. Repositorio de Producción Científica
Idioma:inglés
OAI Identifier:oai:abacus.universidadeuropea.com:11268/12820
Acceso en línea:http://hdl.handle.net/11268/12820
Access Level:acceso abierto
Palabra clave:Ginecología
Síndrome del ovario poliquístico
Sistema endocrino
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spelling Evaluation of the efficacy of an antioxidant combination for the modulation of metabolic, endocrine, and clinical parameters in patients with polycystic ovary syndromePingarrón Santofimia, CarmenPoyo Torcal, SilviaLópez Verdú, HelenaHenríquez Linares, AlexandraCalvente Aguilar, VirginiaTerol Sánchez, PabloMartínez García, María SolLafunte González, PilarGinecologíaSíndrome del ovario poliquísticoSistema endocrinoObjective: to evaluate the efficacy of dietary supplementation with a combination of antioxidants (lipoic acid, N-acetylcysteine, vitamin B6, and S-adenosyl-l-methionine) for the modulation of metabolic, endocrine, and clinical parameters in comparison with oral contraception in non-diabetic women newly diagnosed with polycystic ovary syndrome (PcOs). Methods: this was a prospective, partially randomized, multicenter study in which non-diabetic women with PcOs were recruited under routine clinical practice conditions and distributed in three groups to receive the following regimen for 6months: 1) antioxidant combination (MN group); 2) oral contraception (Oc group); or 3) oral contraception and the antioxidant combination (MN + Oc group). General recommendation of healthy diet and regular exercise was given to all patients. Metabolic, endocrine, clinical, and quality of life parameters were recorded at baseline and after 6months of therapy. Results: a total of 96 women with PcOs were included in the study. after 6months of treatment, the homeostasis model assessment-estimated insulin resistance (hOMa-iR) level was reduced only in the MN group, with a significant mean reduction of −0.92 points. androstenedione was significantly reduced in all groups. clinical parameters that significantly improved in all groups were hirsutism, acne, irregular menstruation, and quality of life, with no statistical differences between the groups. Conclusions: this study showed that the antioxidant combination might be a suitable therapy for patients with PcOs when oral contraceptive is not indicated, because in all groups clinical parameters, irregular menstruation as well as androstenedione and quality of life were significantly improved with no statistical difference between groups.20242024-05-1220232023-01-0120232023-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/11268/12820reponame:ABACUS. Repositorio de Producción Científicainstname:Universidad Europea (UEM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:abacus.universidadeuropea.com:11268/128202026-06-11T12:41:27Z
dc.title.none.fl_str_mv Evaluation of the efficacy of an antioxidant combination for the modulation of metabolic, endocrine, and clinical parameters in patients with polycystic ovary syndrome
title Evaluation of the efficacy of an antioxidant combination for the modulation of metabolic, endocrine, and clinical parameters in patients with polycystic ovary syndrome
spellingShingle Evaluation of the efficacy of an antioxidant combination for the modulation of metabolic, endocrine, and clinical parameters in patients with polycystic ovary syndrome
Pingarrón Santofimia, Carmen
Ginecología
Síndrome del ovario poliquístico
Sistema endocrino
title_short Evaluation of the efficacy of an antioxidant combination for the modulation of metabolic, endocrine, and clinical parameters in patients with polycystic ovary syndrome
title_full Evaluation of the efficacy of an antioxidant combination for the modulation of metabolic, endocrine, and clinical parameters in patients with polycystic ovary syndrome
title_fullStr Evaluation of the efficacy of an antioxidant combination for the modulation of metabolic, endocrine, and clinical parameters in patients with polycystic ovary syndrome
title_full_unstemmed Evaluation of the efficacy of an antioxidant combination for the modulation of metabolic, endocrine, and clinical parameters in patients with polycystic ovary syndrome
title_sort Evaluation of the efficacy of an antioxidant combination for the modulation of metabolic, endocrine, and clinical parameters in patients with polycystic ovary syndrome
dc.creator.none.fl_str_mv Pingarrón Santofimia, Carmen
Poyo Torcal, Silvia
López Verdú, Helena
Henríquez Linares, Alexandra
Calvente Aguilar, Virginia
Terol Sánchez, Pablo
Martínez García, María Sol
Lafunte González, Pilar
author Pingarrón Santofimia, Carmen
author_facet Pingarrón Santofimia, Carmen
Poyo Torcal, Silvia
López Verdú, Helena
Henríquez Linares, Alexandra
Calvente Aguilar, Virginia
Terol Sánchez, Pablo
Martínez García, María Sol
Lafunte González, Pilar
author_role author
author2 Poyo Torcal, Silvia
López Verdú, Helena
Henríquez Linares, Alexandra
Calvente Aguilar, Virginia
Terol Sánchez, Pablo
Martínez García, María Sol
Lafunte González, Pilar
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Ginecología
Síndrome del ovario poliquístico
Sistema endocrino
topic Ginecología
Síndrome del ovario poliquístico
Sistema endocrino
description Objective: to evaluate the efficacy of dietary supplementation with a combination of antioxidants (lipoic acid, N-acetylcysteine, vitamin B6, and S-adenosyl-l-methionine) for the modulation of metabolic, endocrine, and clinical parameters in comparison with oral contraception in non-diabetic women newly diagnosed with polycystic ovary syndrome (PcOs). Methods: this was a prospective, partially randomized, multicenter study in which non-diabetic women with PcOs were recruited under routine clinical practice conditions and distributed in three groups to receive the following regimen for 6months: 1) antioxidant combination (MN group); 2) oral contraception (Oc group); or 3) oral contraception and the antioxidant combination (MN + Oc group). General recommendation of healthy diet and regular exercise was given to all patients. Metabolic, endocrine, clinical, and quality of life parameters were recorded at baseline and after 6months of therapy. Results: a total of 96 women with PcOs were included in the study. after 6months of treatment, the homeostasis model assessment-estimated insulin resistance (hOMa-iR) level was reduced only in the MN group, with a significant mean reduction of −0.92 points. androstenedione was significantly reduced in all groups. clinical parameters that significantly improved in all groups were hirsutism, acne, irregular menstruation, and quality of life, with no statistical differences between the groups. Conclusions: this study showed that the antioxidant combination might be a suitable therapy for patients with PcOs when oral contraceptive is not indicated, because in all groups clinical parameters, irregular menstruation as well as androstenedione and quality of life were significantly improved with no statistical difference between groups.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-01-01
2023
2023-01-01
2024
2024-05-12
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/11268/12820
url http://hdl.handle.net/11268/12820
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:ABACUS. Repositorio de Producción Científica
instname:Universidad Europea (UEM)
instname_str Universidad Europea (UEM)
reponame_str ABACUS. Repositorio de Producción Científica
collection ABACUS. Repositorio de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300719

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