Familial hypercholesterolemia: do HDL play a role

Cardiovascular disease (CVD) in heterozygous familial hypercholesterolemia (HeFH), the most frequent monogenic disorder of human metabolism, is largely driven by low-density lipoprotein (LDL) cholesterol concentrations. Since the CVD rate differs considerably in this population, beyond the lifetime...

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Detalhes bibliográficos
Autores: Pedro-Botet, Juan, Climent, Elisenda, Benaiges Foix, David
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/53163
Acesso em linha:http://hdl.handle.net/10230/53163
http://dx.doi.org/10.3390/biomedicines9070810
Access Level:acceso abierto
Palavra-chave:HDL functionality
Cardiovascular disease
Epigenetics
Familial hypercholesterolemia
Genetics
High density lipoproteins
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spelling Familial hypercholesterolemia: do HDL play a rolePedro-Botet, JuanCliment, ElisendaBenaiges Foix, DavidHDL functionalityCardiovascular diseaseEpigeneticsFamilial hypercholesterolemiaGeneticsHigh density lipoproteinsCardiovascular disease (CVD) in heterozygous familial hypercholesterolemia (HeFH), the most frequent monogenic disorder of human metabolism, is largely driven by low-density lipoprotein (LDL) cholesterol concentrations. Since the CVD rate differs considerably in this population, beyond the lifetime LDL cholesterol vascular accumulation, other classical risk factors are involved in the high cardiovascular risk of HeFH. Among other lipoprotein disturbances, alterations in the phenotype and functionality of high-density lipoproteins (HDL) have been described in HeFH patients, contributing to the presence and severity of CVD. In fact, HDL are the first defensive barrier against the burden of high LDL cholesterol levels owing to their contribution to reverse cholesterol transport as well as their antioxidant and anti-inflammatory properties, among others. In this context, the present narrative review aimed to focus on quantitative and qualitative abnormalities in HDL particles in HeFH, encompassing metabolic, genetic and epigenetic aspects.MDPI202220222021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/53163http://dx.doi.org/10.3390/biomedicines9070810reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésCopyright © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/531632026-05-29T05:05:01Z
dc.title.none.fl_str_mv Familial hypercholesterolemia: do HDL play a role
title Familial hypercholesterolemia: do HDL play a role
spellingShingle Familial hypercholesterolemia: do HDL play a role
Pedro-Botet, Juan
HDL functionality
Cardiovascular disease
Epigenetics
Familial hypercholesterolemia
Genetics
High density lipoproteins
title_short Familial hypercholesterolemia: do HDL play a role
title_full Familial hypercholesterolemia: do HDL play a role
title_fullStr Familial hypercholesterolemia: do HDL play a role
title_full_unstemmed Familial hypercholesterolemia: do HDL play a role
title_sort Familial hypercholesterolemia: do HDL play a role
dc.creator.none.fl_str_mv Pedro-Botet, Juan
Climent, Elisenda
Benaiges Foix, David
author Pedro-Botet, Juan
author_facet Pedro-Botet, Juan
Climent, Elisenda
Benaiges Foix, David
author_role author
author2 Climent, Elisenda
Benaiges Foix, David
author2_role author
author
dc.subject.none.fl_str_mv HDL functionality
Cardiovascular disease
Epigenetics
Familial hypercholesterolemia
Genetics
High density lipoproteins
topic HDL functionality
Cardiovascular disease
Epigenetics
Familial hypercholesterolemia
Genetics
High density lipoproteins
description Cardiovascular disease (CVD) in heterozygous familial hypercholesterolemia (HeFH), the most frequent monogenic disorder of human metabolism, is largely driven by low-density lipoprotein (LDL) cholesterol concentrations. Since the CVD rate differs considerably in this population, beyond the lifetime LDL cholesterol vascular accumulation, other classical risk factors are involved in the high cardiovascular risk of HeFH. Among other lipoprotein disturbances, alterations in the phenotype and functionality of high-density lipoproteins (HDL) have been described in HeFH patients, contributing to the presence and severity of CVD. In fact, HDL are the first defensive barrier against the burden of high LDL cholesterol levels owing to their contribution to reverse cholesterol transport as well as their antioxidant and anti-inflammatory properties, among others. In this context, the present narrative review aimed to focus on quantitative and qualitative abnormalities in HDL particles in HeFH, encompassing metabolic, genetic and epigenetic aspects.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/53163
http://dx.doi.org/10.3390/biomedicines9070810
url http://hdl.handle.net/10230/53163
http://dx.doi.org/10.3390/biomedicines9070810
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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