Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis.
Tumor-secreted extracellular vesicles (EVs) are critical mediators of intercellular communication between tumor cells and stromal cells in local and distant microenvironments. Accordingly, EVs play an essential role in both primary tumor growth and metastatic evolution. EVs orchestrate multiple syst...
| Autores: | , , , , , |
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| Tipo de documento: | artigo |
| Data de publicação: | 2016 |
| País: | España |
| Recursos: | Instituto de Salud Carlos III (ISCIII) |
| Repositório: | Repisalud |
| Idioma: | inglês |
| OAI Identifier: | oai:repisalud.isciii.es:20.500.12105/17974 |
| Acesso em linha: | http://hdl.handle.net/20.500.12105/17974 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Biomarkers, Tumor Cell Communication Exosomes Extracellular Vesicles Humans Neoplasm Metastasis Neoplasms Prognosis Tumor Microenvironment |
| Resumo: | Tumor-secreted extracellular vesicles (EVs) are critical mediators of intercellular communication between tumor cells and stromal cells in local and distant microenvironments. Accordingly, EVs play an essential role in both primary tumor growth and metastatic evolution. EVs orchestrate multiple systemic pathophysiological processes, such as coagulation, vascular leakiness, and reprogramming of stromal recipient cells to support pre-metastatic niche formation and subsequent metastasis. Clinically, EVs may be biomarkers and novel therapeutic targets for cancer progression, particularly for predicting and preventing future metastatic development. |
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