The Susceptibility Trends of Respiratory and Enteric Porcine Pathogens to Last-Resource Antimicrobials

Monitoring the antimicrobial susceptibility of last-resource antimicrobials for veterinary pathogens is urgently needed from a one-health perspective. The objective of this study was to analyze the antimicrobial susceptibility trends of Spanish porcine bacteria to quinolones, cephalosporins, and pol...

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Autores: Vilaró, Anna, Novell, Elena, Enrique-Tarancon, Vicens, Baliellas, Jordi, Migura-Garcia, Lourdes|||0000-0003-2935-928X, Fraile, Lorenzo|||0000-0002-8980-5862
Formato: artículo
Fecha de publicación:2023
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:289721
Acesso em linha:https://ddd.uab.cat/record/289721
https://dx.doi.org/urn:doi:10.3390/antibiotics12111575
Access Level:acceso abierto
Palavra-chave:Trend analysis
Antimicrobial susceptibility
Porcine pathogens
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spelling The Susceptibility Trends of Respiratory and Enteric Porcine Pathogens to Last-Resource AntimicrobialsVilaró, AnnaNovell, ElenaEnrique-Tarancon, VicensBaliellas, JordiMigura-Garcia, Lourdes|||0000-0003-2935-928XFraile, Lorenzo|||0000-0002-8980-5862Trend analysisAntimicrobial susceptibilityPorcine pathogensMonitoring the antimicrobial susceptibility of last-resource antimicrobials for veterinary pathogens is urgently needed from a one-health perspective. The objective of this study was to analyze the antimicrobial susceptibility trends of Spanish porcine bacteria to quinolones, cephalosporins, and polymyxins. Isolates of Actinobacillus pleuropneumoniae, Pasteurella multocida, and Escherichia coli were isolated from sick pigs from 2019 to 2022. An antimicrobial susceptibility test was determined based on the minimal inhibitory concentration (MIC) following an internationally accepted methodology. The MIC categorization was based on distributing the range of MIC values in four categories, with category one being the most susceptible (lowest MIC value) and category four the least susceptible (highest MIC value). Moreover, clinical susceptibility (susceptible/non-susceptible) was also determined according to the CLSI and EUCAST clinical breakpoints. A logistic and multinomial logistic regression model was used to analyze the susceptibility data for dichotomized and categorized MIC data, respectively, for any pair of antimicrobial/microorganism. In general terms, the antimicrobial susceptibility of pig bacteria to these antimicrobials remained stable or increased in the last four years in Spain. In the case of A. pleuropneumoniae and quinolones, a significant temporal trend was observed where isolates from 2020 had significantly increased odds of being more susceptible than isolates from 2019. In the case of E. coli and polymyxins, a significant temporal trend was observed where isolates from 2020 and 2021 had significantly increased odds of being more susceptible than isolates from 2019 and 2020, respectively. Finally, significant odds of being less susceptible were only observed for cephalosporins and E. coli for 2020 versus 2019, stagnating for the rest of study period. These results provide sound data on critically important antimicrobials in swine medicine. 22023-01-0120232023-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/289721https://dx.doi.org/urn:doi:10.3390/antibiotics12111575reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2897212026-06-06T12:50:31Z
dc.title.none.fl_str_mv The Susceptibility Trends of Respiratory and Enteric Porcine Pathogens to Last-Resource Antimicrobials
title The Susceptibility Trends of Respiratory and Enteric Porcine Pathogens to Last-Resource Antimicrobials
spellingShingle The Susceptibility Trends of Respiratory and Enteric Porcine Pathogens to Last-Resource Antimicrobials
Vilaró, Anna
Trend analysis
Antimicrobial susceptibility
Porcine pathogens
title_short The Susceptibility Trends of Respiratory and Enteric Porcine Pathogens to Last-Resource Antimicrobials
title_full The Susceptibility Trends of Respiratory and Enteric Porcine Pathogens to Last-Resource Antimicrobials
title_fullStr The Susceptibility Trends of Respiratory and Enteric Porcine Pathogens to Last-Resource Antimicrobials
title_full_unstemmed The Susceptibility Trends of Respiratory and Enteric Porcine Pathogens to Last-Resource Antimicrobials
title_sort The Susceptibility Trends of Respiratory and Enteric Porcine Pathogens to Last-Resource Antimicrobials
dc.creator.none.fl_str_mv Vilaró, Anna
Novell, Elena
Enrique-Tarancon, Vicens
Baliellas, Jordi
Migura-Garcia, Lourdes|||0000-0003-2935-928X
Fraile, Lorenzo|||0000-0002-8980-5862
author Vilaró, Anna
author_facet Vilaró, Anna
Novell, Elena
Enrique-Tarancon, Vicens
Baliellas, Jordi
Migura-Garcia, Lourdes|||0000-0003-2935-928X
Fraile, Lorenzo|||0000-0002-8980-5862
author_role author
author2 Novell, Elena
Enrique-Tarancon, Vicens
Baliellas, Jordi
Migura-Garcia, Lourdes|||0000-0003-2935-928X
Fraile, Lorenzo|||0000-0002-8980-5862
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Trend analysis
Antimicrobial susceptibility
Porcine pathogens
topic Trend analysis
Antimicrobial susceptibility
Porcine pathogens
description Monitoring the antimicrobial susceptibility of last-resource antimicrobials for veterinary pathogens is urgently needed from a one-health perspective. The objective of this study was to analyze the antimicrobial susceptibility trends of Spanish porcine bacteria to quinolones, cephalosporins, and polymyxins. Isolates of Actinobacillus pleuropneumoniae, Pasteurella multocida, and Escherichia coli were isolated from sick pigs from 2019 to 2022. An antimicrobial susceptibility test was determined based on the minimal inhibitory concentration (MIC) following an internationally accepted methodology. The MIC categorization was based on distributing the range of MIC values in four categories, with category one being the most susceptible (lowest MIC value) and category four the least susceptible (highest MIC value). Moreover, clinical susceptibility (susceptible/non-susceptible) was also determined according to the CLSI and EUCAST clinical breakpoints. A logistic and multinomial logistic regression model was used to analyze the susceptibility data for dichotomized and categorized MIC data, respectively, for any pair of antimicrobial/microorganism. In general terms, the antimicrobial susceptibility of pig bacteria to these antimicrobials remained stable or increased in the last four years in Spain. In the case of A. pleuropneumoniae and quinolones, a significant temporal trend was observed where isolates from 2020 had significantly increased odds of being more susceptible than isolates from 2019. In the case of E. coli and polymyxins, a significant temporal trend was observed where isolates from 2020 and 2021 had significantly increased odds of being more susceptible than isolates from 2019 and 2020, respectively. Finally, significant odds of being less susceptible were only observed for cephalosporins and E. coli for 2020 versus 2019, stagnating for the rest of study period. These results provide sound data on critically important antimicrobials in swine medicine.
publishDate 2023
dc.date.none.fl_str_mv 2
2023-01-01
2023
2023-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/289721
https://dx.doi.org/urn:doi:10.3390/antibiotics12111575
url https://ddd.uab.cat/record/289721
https://dx.doi.org/urn:doi:10.3390/antibiotics12111575
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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