Cutaneous infection with alternaria triticina in a bilateral lung transplant recipient

We report the case of a 60-year-old man who was receiving immunosuppressive therapy for a bilateral lung transplant and presented with a crusted, violaceous plaque on the left hand. Based on histopathology and microbiological culture the patient was diagnosed with infection by Alternaria species. Tr...

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Autores: González Vela, María del Carmen, Armesto Alonso, Susana, Unda-Villafuerte, F., Val Bernal, José Fernando|||0000-0002-5360-9982
Formato: artículo
Fecha de publicación:2014
País:España
Recursos:Universidad de Cantabria (UC)
Repositorio:UCrea Repositorio Abierto de la Universidad de Cantabria
Idioma:inglés
OAI Identifier:oai:repositorio.unican.es:10902/29037
Acesso em linha:https://hdl.handle.net/10902/29037
Access Level:acceso abierto
Palavra-chave:Phaehyphomycoses
Organ transplantation
Cutaneous alternariosis
Alternaria triticina
Feohifomicosis
Trasplante de órganos
Alternariosis cutánea
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spelling Cutaneous infection with alternaria triticina in a bilateral lung transplant recipientInfección cutánea por Alternaria triticina en un paciente con trasplante bilateral de pulmónGonzález Vela, María del CarmenArmesto Alonso, SusanaUnda-Villafuerte, F.Val Bernal, José Fernando|||0000-0002-5360-9982PhaehyphomycosesOrgan transplantationCutaneous alternariosisAlternaria triticinaFeohifomicosisTrasplante de órganosAlternariosis cutáneaAlternaria triticinaWe report the case of a 60-year-old man who was receiving immunosuppressive therapy for a bilateral lung transplant and presented with a crusted, violaceous plaque on the left hand. Based on histopathology and microbiological culture the patient was diagnosed with infection by Alternaria species. Treatment with itraconazole led to complete resolution of the skin lesion. Forty months later he developed four reddish, nodular, skin lesions on the left leg. Analysis of a biopsy from one of these lesions using histopathologic and molecular techniques identified a mold that shared 98% homology with a strain of Alternaria triticina. Alternaria species belong to a group of dematiaceous fungi that cause opportunistic infections in humans. The incidence of these infections is increasing, mainly in transplant centers. To the best of our knowledge, this is the first reported case of a human infection caused by A. triticinaPresentamos el caso de un hombre de 60 años en tratamiento inmunosupresor por un trasplante pulmonar bilateral que presentó una placa violácea costrosa en la mano. Se diagnosticó de infección por Alternaria spp mediante estudio histopatológico y cultivo microbiológico. El tratamiento con itraconazol condujo a la resolución completa de la lesión cutánea. Cuarenta meses más tarde el paciente desarrolló 4 lesiones nodulares rojizas en la pierna izquierda. Las muestras obtenidas de una de las lesiones fueron estudiadas mediante histopatología y técnicas moleculares. La secuencia de ADN que se obtuvo del germen causal mostraba una homología del 98% con una cepa de Alternaria triticina. Las especies de Alternaria forman parte del grupo de hongos que componen las feohifomicosis susceptibles de causar infecciones oportunísticas humanas. La incidencia de estas infecciones está aumentando, sobre todo en centros de trasplante. De acuerdo con nuestra información el presente caso es el primero en el que A. triticina es causante de una infección humanaAcknowledgement: We thank Manuel Cuenca Estrella and Emilia Mellado of the Instituto Nacional de Salud Carlos III in Madrid for confirmation of the identity of the fungus.ElsevierUniversidad de Cantabria20142014-01-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articlehttps://hdl.handle.net/10902/29037ActasDermosifiliogr., 2014, 105(8), e51 - e54reponame:UCrea Repositorio Abierto de la Universidad de Cantabriainstname:Universidad de Cantabria (UC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repositorio.unican.es:10902/290372026-06-02T12:39:31Z
dc.title.none.fl_str_mv Cutaneous infection with alternaria triticina in a bilateral lung transplant recipient
Infección cutánea por Alternaria triticina en un paciente con trasplante bilateral de pulmón
title Cutaneous infection with alternaria triticina in a bilateral lung transplant recipient
spellingShingle Cutaneous infection with alternaria triticina in a bilateral lung transplant recipient
González Vela, María del Carmen
Phaehyphomycoses
Organ transplantation
Cutaneous alternariosis
Alternaria triticina
Feohifomicosis
Trasplante de órganos
Alternariosis cutánea
Alternaria triticina
title_short Cutaneous infection with alternaria triticina in a bilateral lung transplant recipient
title_full Cutaneous infection with alternaria triticina in a bilateral lung transplant recipient
title_fullStr Cutaneous infection with alternaria triticina in a bilateral lung transplant recipient
title_full_unstemmed Cutaneous infection with alternaria triticina in a bilateral lung transplant recipient
title_sort Cutaneous infection with alternaria triticina in a bilateral lung transplant recipient
dc.creator.none.fl_str_mv González Vela, María del Carmen
Armesto Alonso, Susana
Unda-Villafuerte, F.
Val Bernal, José Fernando|||0000-0002-5360-9982
author González Vela, María del Carmen
author_facet González Vela, María del Carmen
Armesto Alonso, Susana
Unda-Villafuerte, F.
Val Bernal, José Fernando|||0000-0002-5360-9982
author_role author
author2 Armesto Alonso, Susana
Unda-Villafuerte, F.
Val Bernal, José Fernando|||0000-0002-5360-9982
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidad de Cantabria
dc.subject.none.fl_str_mv Phaehyphomycoses
Organ transplantation
Cutaneous alternariosis
Alternaria triticina
Feohifomicosis
Trasplante de órganos
Alternariosis cutánea
Alternaria triticina
topic Phaehyphomycoses
Organ transplantation
Cutaneous alternariosis
Alternaria triticina
Feohifomicosis
Trasplante de órganos
Alternariosis cutánea
Alternaria triticina
description We report the case of a 60-year-old man who was receiving immunosuppressive therapy for a bilateral lung transplant and presented with a crusted, violaceous plaque on the left hand. Based on histopathology and microbiological culture the patient was diagnosed with infection by Alternaria species. Treatment with itraconazole led to complete resolution of the skin lesion. Forty months later he developed four reddish, nodular, skin lesions on the left leg. Analysis of a biopsy from one of these lesions using histopathologic and molecular techniques identified a mold that shared 98% homology with a strain of Alternaria triticina. Alternaria species belong to a group of dematiaceous fungi that cause opportunistic infections in humans. The incidence of these infections is increasing, mainly in transplant centers. To the best of our knowledge, this is the first reported case of a human infection caused by A. triticina
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10902/29037
url https://hdl.handle.net/10902/29037
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv ActasDermosifiliogr., 2014, 105(8), e51 - e54
reponame:UCrea Repositorio Abierto de la Universidad de Cantabria
instname:Universidad de Cantabria (UC)
instname_str Universidad de Cantabria (UC)
reponame_str UCrea Repositorio Abierto de la Universidad de Cantabria
collection UCrea Repositorio Abierto de la Universidad de Cantabria
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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