Maternal obesity damages the median eminence blood-brain barrier structure and function in the progeny: the beneficial impact of cross-fostering by lean mothers

Maternal dietary habits directly influence offspring health. In this study, we aimed at determining the impact of maternal obesity on BBB integrity. We show that DIO offspring presented a leakier ME–BBB, accompanied by changes in the expression of transcripts encoding for endothelial and tanycytic p...

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Detalles Bibliográficos
Autores: Haddad Tovolli, Roberta, Morari, Joseane, Barbizan, Roberta, Bóbbo, Vanessa, Carraro, Rodrigo, Solon, Carina, Dragano, Nathalia, Torsoni, Márcio, Araujo, Eliana, Velloso, Licio
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2023
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/203656
Acceso en línea:https://hdl.handle.net/2445/203656
Access Level:acceso abierto
Palabra clave:Obesitat
Maternitat
Obesity
Motherhood
Descripción
Sumario:Maternal dietary habits directly influence offspring health. In this study, we aimed at determining the impact of maternal obesity on BBB integrity. We show that DIO offspring presented a leakier ME–BBB, accompanied by changes in the expression of transcripts encoding for endothelial and tanycytic proteins, as well as of hypothalamic neuropeptides. Breastfeeding in lean dams was sufficient to protect the offspring from ME–BBB disruption, providing a preventive strategy of nutritional intervention during early life.

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