Compartments and the control of growth in the Drosophila wing imaginal disc

The mechanisms that control organ growth are among the least known in development. This is particularly the case for the process in which growth is arrested once final size is reached. We have studied this problem in the wing disc of Drosophila, the developmental and growth parameters of which are w...

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Detalhes bibliográficos
Autores: Martín, Francisco A., Morata, Ginés
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2006
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/149980
Acesso em linha:http://hdl.handle.net/10261/149980
Access Level:acceso abierto
Palavra-chave:Growth control
Compartments
Drosophila
Wing disc
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spelling Compartments and the control of growth in the Drosophila wing imaginal discMartín, Francisco A.Morata, GinésGrowth controlCompartmentsDrosophilaWing discThe mechanisms that control organ growth are among the least known in development. This is particularly the case for the process in which growth is arrested once final size is reached. We have studied this problem in the wing disc of Drosophila, the developmental and growth parameters of which are well known. We have devised a method to generate entire fast-growing Minute+ (M+) discs or compartments in slow developing Minute/+ (M/+) larvae. Under these conditions, a M+ wing disc gains at least 20 hours of additional development time. Yet it grows to the same size of Minute/+ discs developing in M/+ larvae. We have also generated wing discs in which all the cells in either the anterior (A) or the posterior (P) compartment are transformed from M/+ to M+. We find that the difference in the cell division rate of their cells is reflected in autonomous differences in the developmental progression of these compartments: each grows at its own rate and manifests autonomous regulation in the expression of the developmental genes wingless and vestigial. In spite of these differences, 'mosaic'discs comprising fast and slow compartments differentiate into adult wings of the correct size and shape. Our results demonstrate that imaginal discs possess an autonomous mechanism with which to arrest growth in anterior and posterior compartments, which behave as independent developmental units. We propose that this mechanism does not act by preventing cell divisions, but by lengthening the division cycle.Ministry of Science and Technology and an Institutional Grant from the Fundación Ramón ArecesPeer ReviewedCompany of BiologistsFundación Ramón ArecesMinisterio de Ciencia y Tecnología (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2017201720062017info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/149980reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésSíinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1499802026-05-22T06:33:51Z
dc.title.none.fl_str_mv Compartments and the control of growth in the Drosophila wing imaginal disc
title Compartments and the control of growth in the Drosophila wing imaginal disc
spellingShingle Compartments and the control of growth in the Drosophila wing imaginal disc
Martín, Francisco A.
Growth control
Compartments
Drosophila
Wing disc
title_short Compartments and the control of growth in the Drosophila wing imaginal disc
title_full Compartments and the control of growth in the Drosophila wing imaginal disc
title_fullStr Compartments and the control of growth in the Drosophila wing imaginal disc
title_full_unstemmed Compartments and the control of growth in the Drosophila wing imaginal disc
title_sort Compartments and the control of growth in the Drosophila wing imaginal disc
dc.creator.none.fl_str_mv Martín, Francisco A.
Morata, Ginés
author Martín, Francisco A.
author_facet Martín, Francisco A.
Morata, Ginés
author_role author
author2 Morata, Ginés
author2_role author
dc.contributor.none.fl_str_mv Fundación Ramón Areces
Ministerio de Ciencia y Tecnología (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Growth control
Compartments
Drosophila
Wing disc
topic Growth control
Compartments
Drosophila
Wing disc
description The mechanisms that control organ growth are among the least known in development. This is particularly the case for the process in which growth is arrested once final size is reached. We have studied this problem in the wing disc of Drosophila, the developmental and growth parameters of which are well known. We have devised a method to generate entire fast-growing Minute+ (M+) discs or compartments in slow developing Minute/+ (M/+) larvae. Under these conditions, a M+ wing disc gains at least 20 hours of additional development time. Yet it grows to the same size of Minute/+ discs developing in M/+ larvae. We have also generated wing discs in which all the cells in either the anterior (A) or the posterior (P) compartment are transformed from M/+ to M+. We find that the difference in the cell division rate of their cells is reflected in autonomous differences in the developmental progression of these compartments: each grows at its own rate and manifests autonomous regulation in the expression of the developmental genes wingless and vestigial. In spite of these differences, 'mosaic'discs comprising fast and slow compartments differentiate into adult wings of the correct size and shape. Our results demonstrate that imaginal discs possess an autonomous mechanism with which to arrest growth in anterior and posterior compartments, which behave as independent developmental units. We propose that this mechanism does not act by preventing cell divisions, but by lengthening the division cycle.
publishDate 2006
dc.date.none.fl_str_mv 2006
2017
2017
2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/149980
url http://hdl.handle.net/10261/149980
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Company of Biologists
publisher.none.fl_str_mv Company of Biologists
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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