Specific cortical and subcortical alterations for reactive and proactive aggression in children and adolescents with disruptive behavior.

Maladaptive aggression, as present in conduct disorder (CD) and, to a lesser extent, oppositional defiant disorder (ODD), has been associated with structural alterations in various brain regions, such as ventromedial prefrontal cortex (vmPFC), anterior cingulate cortex (ACC), amygdala, insula and ve...

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Detalles Bibliográficos
Autores: Naaijen, Jilly, Mulder, Leandra M., Ilbegi, Shahrzad, Bruijn, Sanne de, Kleine-Deters, Renee, Dietrich, Andrea, Hoekstra, Pieter J., Marsman, Jan-Bernard C., Aggensteiner, Pascal M., Holz, Nathalie E., Boettinger, Boris, Baumeister, Sarah, Banaschewski, Tobias, Saam, Melanie C., Schulze, Ulrike M. E., Santosh, Paramala, Sagar-Ouriaghli, Ilyas, Mastroianni, Mathilde, Castro Fornieles, Josefina, Bargalló Alabart, Núria, Rosa Justicia, Mireia, Arango, Celso, Penzol, Maria J., Werhahn, Julia E., Walitza, Susanne, Brandeis, Daniel, Glennon, Jeffrey C., Franke, Barbara, Zwiers, Marcel P., Buitelaar, Jan K.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/172847
Acceso en línea:https://hdl.handle.net/2445/172847
Access Level:acceso abierto
Palabra clave:Trastorns de la conducta en els adolescents
Trastorns de la conducta en els infants
Conduct disorders in adolescence
Behavior disorders in children
Descripción
Sumario:Maladaptive aggression, as present in conduct disorder (CD) and, to a lesser extent, oppositional defiant disorder (ODD), has been associated with structural alterations in various brain regions, such as ventromedial prefrontal cortex (vmPFC), anterior cingulate cortex (ACC), amygdala, insula and ventral striatum. Although aggression can be subdivided into reactive and proactive subtypes, no neuroimaging studies have yet investigated if any structural brain alterations are associated with either of the subtypes specifically. Here we investigated associations between aggression subtypes, CU traits and ADHD symptoms in predefined regions of interest. T1-weighted magnetic resonance images were acquired from 158 children and adolescents with disruptive behavior (ODD/CD) and 96 controls in a multi-center study (aged 8-18). Aggression subtypes were assessed by questionnaires filled in by participants and their parents. Cortical volume and subcortical volumes and shape were determined using Freesurfer and the FMRIB integrated registration and segmentation tool. Associations between volumes and continuous measures of aggression were established using multilevel linear mixed effects models. Proactive aggression was negatively associated with amygdala volume (b = -10.7, p = 0.02), while reactive aggression was negatively associated with insula volume (b = -21.7, p = 0.01). No associations were found with CU traits or ADHD symptomatology. Classical group comparison showed that children and adolescents with disruptive behavior had smaller volumes than controls in (bilateral) vmPFC (p = 0.003) with modest effect size and a reduced shape in the anterior part of the left ventral striatum (p = 0.005). Our study showed negative associations between reactive aggression and volumes in a region involved in threat responsivity and between proactive aggression and a region linked to empathy. This provides evidence for aggression subtype-specific alterations in brain structure which may provide useful insights for clinical practice.

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