Adrenomedullin in mammalian embryogenesis
Here are summarized data supporting that adrenomedullin (AM) is a multifunctional factor involved in the complex regulatory mechanisms of mammalian development. During rodent embryogenesis, AM is first expressed in the heart, followed by a broader but also defined spatio-temporal pattern of expressi...
| Autores: | , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2002 |
| País: | España |
| Institución: | Universidad de Navarra |
| Repositorio: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | inglés |
| OAI Identifier: | oai:dadun.unav.edu:10171/20187 |
| Acceso en línea: | https://hdl.handle.net/10171/20187 |
| Access Level: | acceso abierto |
| Palabra clave: | Embryonic and Fetal Development Gene Expression Regulation, Developmental Mammals/embryology Peptides/metabolism |
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Adrenomedullin in mammalian embryogenesisGarayoa, M. (Mercedes)|||/items/a54f545f-343f-4c7d-98b6-4b7986d3ff2cBodegas-Frías, M.E. (María Elena)|||/items/d91f92cf-206e-4b2d-a5fd-74db7fafa56aCuttitta, F. (Frank)|||/items/0f0da08c-0efe-4d3c-97ca-44c38a26e188Montuenga-Badia, L.M. (Luis M.)|||/items/4c999705-b2c9-45ac-ba13-3f18594ae596Embryonic and Fetal DevelopmentGene Expression Regulation, DevelopmentalMammals/embryologyPeptides/metabolismHere are summarized data supporting that adrenomedullin (AM) is a multifunctional factor involved in the complex regulatory mechanisms of mammalian development. During rodent embryogenesis, AM is first expressed in the heart, followed by a broader but also defined spatio-temporal pattern of expression in vascular, neural, and skeletal-forming tissues as well as in the main embryonic internal organs. AM pattern of expression is suggestive of its involvement in the control of embryonic invasion, proliferation, and differentiation processes, probably through autocrine or paracrine modes of action. AM levels in fetoplacental tissues, uterus, maternal and umbilical plasma are highly increased during normal gestation. These findings in addition to other physiological and gene targeting studies support the importance of AM as a vasorelaxant factor implicated in the regulation of maternal vascular adaptation to pregnancy, as well as of fetal and fetoplacental circulations. AM is also present in amniotic fluid and milk, which is suggestive of additional functions in the maturation and immunological protection of the fetus. Altered expression of AM has been found in some gestational pathologies, although it is not yet clear whether this corresponds to causative or compensatory mechanisms. Future studies in regard to the distribution and expression levels of the molecules known to function as AM receptors, together with data on the action of complement factor H (an AM binding protein), may help to better define the roles of AM during embryonic development.Wiley BlackwellDadun. Depósito Académico Digital Universidad de Navarra20112011-12-1220022002-01-0120022002-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/20187reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/201872026-06-21T12:47:57Z |
| dc.title.none.fl_str_mv |
Adrenomedullin in mammalian embryogenesis |
| title |
Adrenomedullin in mammalian embryogenesis |
| spellingShingle |
Adrenomedullin in mammalian embryogenesis Garayoa, M. (Mercedes)|||/items/a54f545f-343f-4c7d-98b6-4b7986d3ff2c Embryonic and Fetal Development Gene Expression Regulation, Developmental Mammals/embryology Peptides/metabolism |
| title_short |
Adrenomedullin in mammalian embryogenesis |
| title_full |
Adrenomedullin in mammalian embryogenesis |
| title_fullStr |
Adrenomedullin in mammalian embryogenesis |
| title_full_unstemmed |
Adrenomedullin in mammalian embryogenesis |
| title_sort |
Adrenomedullin in mammalian embryogenesis |
| dc.creator.none.fl_str_mv |
Garayoa, M. (Mercedes)|||/items/a54f545f-343f-4c7d-98b6-4b7986d3ff2c Bodegas-Frías, M.E. (María Elena)|||/items/d91f92cf-206e-4b2d-a5fd-74db7fafa56a Cuttitta, F. (Frank)|||/items/0f0da08c-0efe-4d3c-97ca-44c38a26e188 Montuenga-Badia, L.M. (Luis M.)|||/items/4c999705-b2c9-45ac-ba13-3f18594ae596 |
| author |
Garayoa, M. (Mercedes)|||/items/a54f545f-343f-4c7d-98b6-4b7986d3ff2c |
| author_facet |
Garayoa, M. (Mercedes)|||/items/a54f545f-343f-4c7d-98b6-4b7986d3ff2c Bodegas-Frías, M.E. (María Elena)|||/items/d91f92cf-206e-4b2d-a5fd-74db7fafa56a Cuttitta, F. (Frank)|||/items/0f0da08c-0efe-4d3c-97ca-44c38a26e188 Montuenga-Badia, L.M. (Luis M.)|||/items/4c999705-b2c9-45ac-ba13-3f18594ae596 |
| author_role |
author |
| author2 |
Bodegas-Frías, M.E. (María Elena)|||/items/d91f92cf-206e-4b2d-a5fd-74db7fafa56a Cuttitta, F. (Frank)|||/items/0f0da08c-0efe-4d3c-97ca-44c38a26e188 Montuenga-Badia, L.M. (Luis M.)|||/items/4c999705-b2c9-45ac-ba13-3f18594ae596 |
| author2_role |
author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
Embryonic and Fetal Development Gene Expression Regulation, Developmental Mammals/embryology Peptides/metabolism |
| topic |
Embryonic and Fetal Development Gene Expression Regulation, Developmental Mammals/embryology Peptides/metabolism |
| description |
Here are summarized data supporting that adrenomedullin (AM) is a multifunctional factor involved in the complex regulatory mechanisms of mammalian development. During rodent embryogenesis, AM is first expressed in the heart, followed by a broader but also defined spatio-temporal pattern of expression in vascular, neural, and skeletal-forming tissues as well as in the main embryonic internal organs. AM pattern of expression is suggestive of its involvement in the control of embryonic invasion, proliferation, and differentiation processes, probably through autocrine or paracrine modes of action. AM levels in fetoplacental tissues, uterus, maternal and umbilical plasma are highly increased during normal gestation. These findings in addition to other physiological and gene targeting studies support the importance of AM as a vasorelaxant factor implicated in the regulation of maternal vascular adaptation to pregnancy, as well as of fetal and fetoplacental circulations. AM is also present in amniotic fluid and milk, which is suggestive of additional functions in the maturation and immunological protection of the fetus. Altered expression of AM has been found in some gestational pathologies, although it is not yet clear whether this corresponds to causative or compensatory mechanisms. Future studies in regard to the distribution and expression levels of the molecules known to function as AM receptors, together with data on the action of complement factor H (an AM binding protein), may help to better define the roles of AM during embryonic development. |
| publishDate |
2002 |
| dc.date.none.fl_str_mv |
2002 2002-01-01 2002 2002-01-01 2011 2011-12-12 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10171/20187 |
| url |
https://hdl.handle.net/10171/20187 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Wiley Blackwell |
| publisher.none.fl_str_mv |
Wiley Blackwell |
| dc.source.none.fl_str_mv |
reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra |
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Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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1869406243276193792 |
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15.301603 |