Prognosis of hospitalized patients with 2009 H1N1 influenza in Spain: influence of neuraminidase inhibitors

The H1N1 influenza pandemic strain has been associated with a poor prognosis in hospitalized patients. The present report evaluates the factors influencing prognosis. A total of 813 patients hospitalized with H1N1 influenza in 36 hospitals (nationwide) in Spain were analysed. Detailed histories of v...

Descripción completa

Detalles Bibliográficos
Autores: Delgado-Rodriguez, M, Castilla, J, Godoy, P, Martin, V, Soldevila, N, Alonso, J, Astray, J, Baricot, M, Canton, R, Castro, A, Gonzalez-Candelas, F, Mayoral, JM, Quintana, JM, Pumarola, T, Tamames, S, Saez, M, Dominguez, A, CIBERESP Cases Controls Pandemic
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2012
País:España
Institución:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p12600
Acceso en línea:https://fisabio.portalinvestigacion.com/publicaciones/12600
Access Level:acceso abierto
Palabra clave:prevention
adverse outcomes
length of stay
flu
pandemic
id ES_3a556fad2a5628fa0ee98bfe5533ca4c
oai_identifier_str oai:fisabio.fundanetsuite.com:p12600
network_acronym_str ES
network_name_str España
repository_id_str
spelling Prognosis of hospitalized patients with 2009 H1N1 influenza in Spain: influence of neuraminidase inhibitorsDelgado-Rodriguez, MCastilla, JGodoy, PMartin, VSoldevila, NAlonso, JAstray, JBaricot, MCanton, RCastro, AGonzalez-Candelas, FMayoral, JMQuintana, JMPumarola, TTamames, SSaez, MDominguez, ACIBERESP Cases Controls Pandemicpreventionadverse outcomeslength of stayflupandemicThe H1N1 influenza pandemic strain has been associated with a poor prognosis in hospitalized patients. The present report evaluates the factors influencing prognosis. A total of 813 patients hospitalized with H1N1 influenza in 36 hospitals (nationwide) in Spain were analysed. Detailed histories of variables preceding hospital admission were obtained by interview, validating data on medications and vaccine with their attending physicians. Data on treatment and complications during hospital stay were recorded. As definition of poor outcome, the endpoints of death and admission to intensive care were combined; and as a further outcome, length of stay was used. The mean age was 38.5 years (SD 22.8 years). There were 10 deaths and 79 admissions to intensive care (combined, 88). The use of neuraminidase inhibitors was reported by 495 patients (60.9). The variables significantly associated with a poor outcome were diabetes (OR2.21, 95 CI1.214.02), corticosteroid therapy (OR3.37, 95 CI1.398.20) and use of histamine-2 receptor antagonists (OR2.68, 95 CI1.146.36), while the use of neuraminidase inhibitors (OR0.57, 95 CI0.340.94) was protective. Neuraminidase inhibitors within the first 2 days after the influenza onset reduced hospital stay by a mean of 1.9 days (95 CI4.76.6). The use of neuraminidase inhibitors decreases the length of hospital stay and admission to intensive care and/or death.OXFORD UNIV PRESS2012info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/12600JOURNAL OF ANTIMICROBIAL CHEMOTHERAPYISSN: 03057453ISSNe: 14602091reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p126002026-06-11T12:45:17Z
dc.title.none.fl_str_mv Prognosis of hospitalized patients with 2009 H1N1 influenza in Spain: influence of neuraminidase inhibitors
title Prognosis of hospitalized patients with 2009 H1N1 influenza in Spain: influence of neuraminidase inhibitors
spellingShingle Prognosis of hospitalized patients with 2009 H1N1 influenza in Spain: influence of neuraminidase inhibitors
Delgado-Rodriguez, M
prevention
adverse outcomes
length of stay
flu
pandemic
title_short Prognosis of hospitalized patients with 2009 H1N1 influenza in Spain: influence of neuraminidase inhibitors
title_full Prognosis of hospitalized patients with 2009 H1N1 influenza in Spain: influence of neuraminidase inhibitors
title_fullStr Prognosis of hospitalized patients with 2009 H1N1 influenza in Spain: influence of neuraminidase inhibitors
title_full_unstemmed Prognosis of hospitalized patients with 2009 H1N1 influenza in Spain: influence of neuraminidase inhibitors
title_sort Prognosis of hospitalized patients with 2009 H1N1 influenza in Spain: influence of neuraminidase inhibitors
dc.creator.none.fl_str_mv Delgado-Rodriguez, M
Castilla, J
Godoy, P
Martin, V
Soldevila, N
Alonso, J
Astray, J
Baricot, M
Canton, R
Castro, A
Gonzalez-Candelas, F
Mayoral, JM
Quintana, JM
Pumarola, T
Tamames, S
Saez, M
Dominguez, A
CIBERESP Cases Controls Pandemic
author Delgado-Rodriguez, M
author_facet Delgado-Rodriguez, M
Castilla, J
Godoy, P
Martin, V
Soldevila, N
Alonso, J
Astray, J
Baricot, M
Canton, R
Castro, A
Gonzalez-Candelas, F
Mayoral, JM
Quintana, JM
Pumarola, T
Tamames, S
Saez, M
Dominguez, A
CIBERESP Cases Controls Pandemic
author_role author
author2 Castilla, J
Godoy, P
Martin, V
Soldevila, N
Alonso, J
Astray, J
Baricot, M
Canton, R
Castro, A
Gonzalez-Candelas, F
Mayoral, JM
Quintana, JM
Pumarola, T
Tamames, S
Saez, M
Dominguez, A
CIBERESP Cases Controls Pandemic
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv prevention
adverse outcomes
length of stay
flu
pandemic
topic prevention
adverse outcomes
length of stay
flu
pandemic
description The H1N1 influenza pandemic strain has been associated with a poor prognosis in hospitalized patients. The present report evaluates the factors influencing prognosis. A total of 813 patients hospitalized with H1N1 influenza in 36 hospitals (nationwide) in Spain were analysed. Detailed histories of variables preceding hospital admission were obtained by interview, validating data on medications and vaccine with their attending physicians. Data on treatment and complications during hospital stay were recorded. As definition of poor outcome, the endpoints of death and admission to intensive care were combined; and as a further outcome, length of stay was used. The mean age was 38.5 years (SD 22.8 years). There were 10 deaths and 79 admissions to intensive care (combined, 88). The use of neuraminidase inhibitors was reported by 495 patients (60.9). The variables significantly associated with a poor outcome were diabetes (OR2.21, 95 CI1.214.02), corticosteroid therapy (OR3.37, 95 CI1.398.20) and use of histamine-2 receptor antagonists (OR2.68, 95 CI1.146.36), while the use of neuraminidase inhibitors (OR0.57, 95 CI0.340.94) was protective. Neuraminidase inhibitors within the first 2 days after the influenza onset reduced hospital stay by a mean of 1.9 days (95 CI4.76.6). The use of neuraminidase inhibitors decreases the length of hospital stay and admission to intensive care and/or death.
publishDate 2012
dc.date.none.fl_str_mv 2012
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/12600
url https://fisabio.portalinvestigacion.com/publicaciones/12600
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv OXFORD UNIV PRESS
publisher.none.fl_str_mv OXFORD UNIV PRESS
dc.source.none.fl_str_mv JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
ISSN: 03057453
ISSNe: 14602091
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869406228910702592
score 15.811543

Similares en LA Referencia