Epimacular brachytherapy for wet AMD: current perspectives

Age-related macular degeneration (AMD) is considered the most common cause of blindness in the over-60 age group in developed countries. There are basically two forms of presentation: geographic (dry or atrophic) and wet (neovascular or exudative). Geographic atrophy accounts for approximately 85%-9...

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Detalhes bibliográficos
Autores: Casaroli Marano, Ricardo Pedro, Alforja, Socorro, Giralt, Joan, Farah, Michel E.
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/118736
Acesso em linha:https://hdl.handle.net/2445/118736
Access Level:acceso abierto
Palavra-chave:Radiació
Oftalmopaties
Oftalmologia
Radiation
Eye diseases
Ophthalmology
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spelling Epimacular brachytherapy for wet AMD: current perspectivesCasaroli Marano, Ricardo PedroAlforja, SocorroGiralt, JoanFarah, Michel E.RadiacióOftalmopatiesOftalmologiaRadiationEye diseasesOphthalmologyAge-related macular degeneration (AMD) is considered the most common cause of blindness in the over-60 age group in developed countries. There are basically two forms of presentation: geographic (dry or atrophic) and wet (neovascular or exudative). Geographic atrophy accounts for approximately 85%-90% of ophthalmic frames and leads to a progressive degeneration of the retinal pigment epithelium and the photoreceptors. Wet AMD causes the highest percentage of central vision loss secondary to disease. This neovascular form involves an angiogenic process in which newly formed choroidal vessels invade the macular area. Today, intravitreal anti-angiogenic drugs attempt to block the angiogenic events and represent a major advance in the treatment of wet AMD. Currently, combination therapy for wet AMD includes different forms of radiation delivery. Epimacular brachytherapy (EMBT) seems to be a useful approach to be associated with current anti-vascular endothelial growth factor agents, presenting an acceptable efficacy and safety profile. However, at the present stage of research, the results of the clinical trials carried out to date are insufficient to justify extending routine use of EMBT for the treatment of wet AMD.Dove Medical Press2017201720142017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion10 p.application/pdfhttps://hdl.handle.net/2445/118736Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.2147/OPTH.S46068Clinical Ophthalmology, 2014, vol. 8, p. 1661-1670https://doi.org/10.2147/OPTH.S46068cc-by-nc (c) Casaroli Marano, Ricardo Pedro et al., 2014http://creativecommons.org/licenses/by-nc/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1187362026-05-29T05:05:01Z
dc.title.none.fl_str_mv Epimacular brachytherapy for wet AMD: current perspectives
title Epimacular brachytherapy for wet AMD: current perspectives
spellingShingle Epimacular brachytherapy for wet AMD: current perspectives
Casaroli Marano, Ricardo Pedro
Radiació
Oftalmopaties
Oftalmologia
Radiation
Eye diseases
Ophthalmology
title_short Epimacular brachytherapy for wet AMD: current perspectives
title_full Epimacular brachytherapy for wet AMD: current perspectives
title_fullStr Epimacular brachytherapy for wet AMD: current perspectives
title_full_unstemmed Epimacular brachytherapy for wet AMD: current perspectives
title_sort Epimacular brachytherapy for wet AMD: current perspectives
dc.creator.none.fl_str_mv Casaroli Marano, Ricardo Pedro
Alforja, Socorro
Giralt, Joan
Farah, Michel E.
author Casaroli Marano, Ricardo Pedro
author_facet Casaroli Marano, Ricardo Pedro
Alforja, Socorro
Giralt, Joan
Farah, Michel E.
author_role author
author2 Alforja, Socorro
Giralt, Joan
Farah, Michel E.
author2_role author
author
author
dc.subject.none.fl_str_mv Radiació
Oftalmopaties
Oftalmologia
Radiation
Eye diseases
Ophthalmology
topic Radiació
Oftalmopaties
Oftalmologia
Radiation
Eye diseases
Ophthalmology
description Age-related macular degeneration (AMD) is considered the most common cause of blindness in the over-60 age group in developed countries. There are basically two forms of presentation: geographic (dry or atrophic) and wet (neovascular or exudative). Geographic atrophy accounts for approximately 85%-90% of ophthalmic frames and leads to a progressive degeneration of the retinal pigment epithelium and the photoreceptors. Wet AMD causes the highest percentage of central vision loss secondary to disease. This neovascular form involves an angiogenic process in which newly formed choroidal vessels invade the macular area. Today, intravitreal anti-angiogenic drugs attempt to block the angiogenic events and represent a major advance in the treatment of wet AMD. Currently, combination therapy for wet AMD includes different forms of radiation delivery. Epimacular brachytherapy (EMBT) seems to be a useful approach to be associated with current anti-vascular endothelial growth factor agents, presenting an acceptable efficacy and safety profile. However, at the present stage of research, the results of the clinical trials carried out to date are insufficient to justify extending routine use of EMBT for the treatment of wet AMD.
publishDate 2014
dc.date.none.fl_str_mv 2014
2017
2017
2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/118736
url https://hdl.handle.net/2445/118736
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.2147/OPTH.S46068
Clinical Ophthalmology, 2014, vol. 8, p. 1661-1670
https://doi.org/10.2147/OPTH.S46068
dc.rights.none.fl_str_mv cc-by-nc (c) Casaroli Marano, Ricardo Pedro et al., 2014
http://creativecommons.org/licenses/by-nc/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc (c) Casaroli Marano, Ricardo Pedro et al., 2014
http://creativecommons.org/licenses/by-nc/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 10 p.
application/pdf
dc.publisher.none.fl_str_mv Dove Medical Press
publisher.none.fl_str_mv Dove Medical Press
dc.source.none.fl_str_mv Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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