Transcriptional regulation of multiciliated cell differentiation

Multiciliated cells (MCC) project dozens to hundreds of motile cilia from the cell surface to generate fluid flow across epithelial surfaces or turbulence to promote the transport of gametes. The MCC differentiation program is initiated by GEMC1 and MCIDAS, members of the geminin family, that activa...

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Detalles Bibliográficos
Autores: Lewis, Michael, Stracker, Travis H.
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2020
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/159938
Acceso en línea:https://hdl.handle.net/2445/159938
Access Level:acceso abierto
Palabra clave:Cèl·lules acústiques
Cèl·lules epitelials
Hair cells
Epithelial cells
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spelling Transcriptional regulation of multiciliated cell differentiationLewis, MichaelStracker, Travis H.Cèl·lules acústiquesCèl·lules epitelialsHair cellsEpithelial cellsMulticiliated cells (MCC) project dozens to hundreds of motile cilia from the cell surface to generate fluid flow across epithelial surfaces or turbulence to promote the transport of gametes. The MCC differentiation program is initiated by GEMC1 and MCIDAS, members of the geminin family, that activate key transcription factors, including p73 and FOXJ1, to control the multiciliogenesis program. To support the generation of multiple motile cilia, MCCs must undergo massive centriole amplification to generate a sufficient number of basal bodies (modified centrioles). This transcriptional program involves the generation of deuterosomes, unique structures that act as platforms to regulate centriole amplification, the reactivation of cell cycle programs to control centriole amplification and release, and extensive remodeling of the cytoskeleton. This review will focus on providing an overview of the transcriptional regulation of MCCs and its connection to key processes, in addition to highlighting exciting recent developments and open questions in the field.Elsevier202020212020info:eu-repo/semantics/acceptedVersioninfo:eu-repo/semantics/article28 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/159938Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: https://doi.org/10.1016/j.semcdb.2020.04.007Seminars in Cell & Developmental Biology, 2020https://doi.org/10.1016/j.semcdb.2020.04.007(c) Elsevier, 2020info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1599382026-05-29T05:05:01Z
dc.title.none.fl_str_mv Transcriptional regulation of multiciliated cell differentiation
title Transcriptional regulation of multiciliated cell differentiation
spellingShingle Transcriptional regulation of multiciliated cell differentiation
Lewis, Michael
Cèl·lules acústiques
Cèl·lules epitelials
Hair cells
Epithelial cells
title_short Transcriptional regulation of multiciliated cell differentiation
title_full Transcriptional regulation of multiciliated cell differentiation
title_fullStr Transcriptional regulation of multiciliated cell differentiation
title_full_unstemmed Transcriptional regulation of multiciliated cell differentiation
title_sort Transcriptional regulation of multiciliated cell differentiation
dc.creator.none.fl_str_mv Lewis, Michael
Stracker, Travis H.
author Lewis, Michael
author_facet Lewis, Michael
Stracker, Travis H.
author_role author
author2 Stracker, Travis H.
author2_role author
dc.subject.none.fl_str_mv Cèl·lules acústiques
Cèl·lules epitelials
Hair cells
Epithelial cells
topic Cèl·lules acústiques
Cèl·lules epitelials
Hair cells
Epithelial cells
description Multiciliated cells (MCC) project dozens to hundreds of motile cilia from the cell surface to generate fluid flow across epithelial surfaces or turbulence to promote the transport of gametes. The MCC differentiation program is initiated by GEMC1 and MCIDAS, members of the geminin family, that activate key transcription factors, including p73 and FOXJ1, to control the multiciliogenesis program. To support the generation of multiple motile cilia, MCCs must undergo massive centriole amplification to generate a sufficient number of basal bodies (modified centrioles). This transcriptional program involves the generation of deuterosomes, unique structures that act as platforms to regulate centriole amplification, the reactivation of cell cycle programs to control centriole amplification and release, and extensive remodeling of the cytoskeleton. This review will focus on providing an overview of the transcriptional regulation of MCCs and its connection to key processes, in addition to highlighting exciting recent developments and open questions in the field.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/acceptedVersion
info:eu-repo/semantics/article
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/159938
url https://hdl.handle.net/2445/159938
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1016/j.semcdb.2020.04.007
Seminars in Cell & Developmental Biology, 2020
https://doi.org/10.1016/j.semcdb.2020.04.007
dc.rights.none.fl_str_mv (c) Elsevier, 2020
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Elsevier, 2020
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 28 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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