Blood flow response to orthostatic challenge identifies signatures of the failure of static cerebral autoregulation in patients with cerebrovascular disease
Background The cortical microvascular cerebral blood flow response (CBF) to different changes in head-of-bed (HOB) position has been shown to be altered in acute ischemic stroke (AIS) by diffuse correlation spectroscopy (DCS) technique. However, the relationship between these relative ΔCBF changes a...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | artículo |
| Fecha de publicación: | 2021 |
| País: | España |
| Recursos: | Universitat Politècnica de Catalunya (UPC) |
| Repositorio: | UPCommons. Portal del coneixement obert de la UPC |
| Idioma: | inglés |
| OAI Identifier: | oai:upcommons.upc.edu:2117/347508 |
| Acesso em linha: | https://hdl.handle.net/2117/347508 https://dx.doi.org/10.1186/s12883-021-02179-8 |
| Access Level: | acceso abierto |
| Palavra-chave: | Blood -- Circulation Blood flow Sang -- Circulació Àrees temàtiques de la UPC::Física |
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Blood flow response to orthostatic challenge identifies signatures of the failure of static cerebral autoregulation in patients with cerebrovascular diseaseGregori-Pla, ClaraMesquita, Rickson C.Favilla, Christopher G.Busch, David R.Blanco, IgorZirak, PeymanLisa Kobayashi, FriskAvtzi, StellaMaruccia, FedericaGiacalone, GiacomoCotta, GianlucaCamps-Renom, PolMullen, Michael T.Martí-Fàbregas, JoanPrats-Sánchez, LuísMartínez-Domeño, AlejandroKasner, Scott E.Greenberg, Joel H.Zhou, ChaoEdlow, Brian L.Putt, Mary E.Detre, John A.Yodh, Arjun G.Durduran, TurgutDelgado-Mederos, RaquelBlood -- CirculationBlood flowSang -- CirculacióÀrees temàtiques de la UPC::FísicaBackground The cortical microvascular cerebral blood flow response (CBF) to different changes in head-of-bed (HOB) position has been shown to be altered in acute ischemic stroke (AIS) by diffuse correlation spectroscopy (DCS) technique. However, the relationship between these relative ΔCBF changes and associated systemic blood pressure changes has not been studied, even though blood pressure is a major driver of cerebral blood flow. Methods Transcranial DCS data from four studies measuring bilateral frontal microvascular cerebral blood flow in healthy controls (n = 15), patients with asymptomatic severe internal carotid artery stenosis (ICA, n = 27), and patients with acute ischemic stroke (AIS, n = 72) were aggregated. DCS-measured CBF was measured in response to a short head-of-bed (HOB) position manipulation protocol (supine/elevated/supine, 5 min at each position). In a sub-group (AIS, n = 26; ICA, n = 14; control, n = 15), mean arterial pressure (MAP) was measured dynamically during the protocol. Results After elevated positioning, DCS CBF returned to baseline supine values in controls (p = 0.890) but not in patients with AIS (9.6% [6.0,13.3], mean 95% CI, p < 0.001) or ICA stenosis (8.6% [3.1,14.0], p = 0.003)). MAP in AIS patients did not return to baseline values (2.6 mmHg [0.5, 4.7], p = 0.018), but in ICA stenosis patients and controls did. Instead ipsilesional but not contralesional CBF was correlated with MAP (AIS 6.0%/mmHg [− 2.4,14.3], p = 0.038; ICA stenosis 11.0%/mmHg [2.4,19.5], p < 0.001). Conclusions The observed associations between ipsilateral CBF and MAP suggest that short HOB position changes may elicit deficits in cerebral autoregulation in cerebrovascular disorders. Additional research is required to further characterize this phenomenon.Peer ReviewedBMC20212021-04-0920212021-06-18journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/347508https://dx.doi.org/10.1186/s12883-021-02179-8reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)InglésengMinisterio de Economía y Competitividad http://doi.org/10.13039/501100003329 DPI2015-64358-C2-1-R RED MULTIDISCIPLINAR DE TECNOLOGIAS OPTICAS NOVEDOSAS PARA LA TOMOGRAFIA NO INVASIVA DELA PERFUSION CEREBRAL COMO BIOMARCADOR EN PATOLOGIAS CEREBRALESMinisterio de Economía y Competitividad http://doi.org/10.13039/501100003329 DTS16%2F00087 MEDical PHOTonics platform for AGEing (MEDPHOTAGE): Plataforma fotónica, no invasiva, tipo "point-of-care", para la evaluación del riesgo cerebrovascular asociado con el envejecimientoMinisterio de Economía y Competitividad http://doi.org/10.13039/501100003329 SEV-2015-0522 AGR-INSTITUTO DE CIENCIAS FOTONICASEuropean Commission http://doi.org/10.13039/100010661 Horizon 2020 Framework Programme 654148 The Integrated Initiative of European Laser Research InfrastructuresEuropean Commission http://doi.org/10.13039/100010661 Horizon 2020 Framework Programme 654148 The Integrated Initiative of European Laser Research Infrastructuresopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 3.0 Spainhttp://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/3475082026-05-27T15:37:01Z |
| dc.title.none.fl_str_mv |
Blood flow response to orthostatic challenge identifies signatures of the failure of static cerebral autoregulation in patients with cerebrovascular disease |
| title |
Blood flow response to orthostatic challenge identifies signatures of the failure of static cerebral autoregulation in patients with cerebrovascular disease |
| spellingShingle |
Blood flow response to orthostatic challenge identifies signatures of the failure of static cerebral autoregulation in patients with cerebrovascular disease Gregori-Pla, Clara Blood -- Circulation Blood flow Sang -- Circulació Àrees temàtiques de la UPC::Física |
| title_short |
Blood flow response to orthostatic challenge identifies signatures of the failure of static cerebral autoregulation in patients with cerebrovascular disease |
| title_full |
Blood flow response to orthostatic challenge identifies signatures of the failure of static cerebral autoregulation in patients with cerebrovascular disease |
| title_fullStr |
Blood flow response to orthostatic challenge identifies signatures of the failure of static cerebral autoregulation in patients with cerebrovascular disease |
| title_full_unstemmed |
Blood flow response to orthostatic challenge identifies signatures of the failure of static cerebral autoregulation in patients with cerebrovascular disease |
| title_sort |
Blood flow response to orthostatic challenge identifies signatures of the failure of static cerebral autoregulation in patients with cerebrovascular disease |
| dc.creator.none.fl_str_mv |
Gregori-Pla, Clara Mesquita, Rickson C. Favilla, Christopher G. Busch, David R. Blanco, Igor Zirak, Peyman Lisa Kobayashi, Frisk Avtzi, Stella Maruccia, Federica Giacalone, Giacomo Cotta, Gianluca Camps-Renom, Pol Mullen, Michael T. Martí-Fàbregas, Joan Prats-Sánchez, Luís Martínez-Domeño, Alejandro Kasner, Scott E. Greenberg, Joel H. Zhou, Chao Edlow, Brian L. Putt, Mary E. Detre, John A. Yodh, Arjun G. Durduran, Turgut Delgado-Mederos, Raquel |
| author |
Gregori-Pla, Clara |
| author_facet |
Gregori-Pla, Clara Mesquita, Rickson C. Favilla, Christopher G. Busch, David R. Blanco, Igor Zirak, Peyman Lisa Kobayashi, Frisk Avtzi, Stella Maruccia, Federica Giacalone, Giacomo Cotta, Gianluca Camps-Renom, Pol Mullen, Michael T. Martí-Fàbregas, Joan Prats-Sánchez, Luís Martínez-Domeño, Alejandro Kasner, Scott E. Greenberg, Joel H. Zhou, Chao Edlow, Brian L. Putt, Mary E. Detre, John A. Yodh, Arjun G. Durduran, Turgut Delgado-Mederos, Raquel |
| author_role |
author |
| author2 |
Mesquita, Rickson C. Favilla, Christopher G. Busch, David R. Blanco, Igor Zirak, Peyman Lisa Kobayashi, Frisk Avtzi, Stella Maruccia, Federica Giacalone, Giacomo Cotta, Gianluca Camps-Renom, Pol Mullen, Michael T. Martí-Fàbregas, Joan Prats-Sánchez, Luís Martínez-Domeño, Alejandro Kasner, Scott E. Greenberg, Joel H. Zhou, Chao Edlow, Brian L. Putt, Mary E. Detre, John A. Yodh, Arjun G. Durduran, Turgut Delgado-Mederos, Raquel |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Blood -- Circulation Blood flow Sang -- Circulació Àrees temàtiques de la UPC::Física |
| topic |
Blood -- Circulation Blood flow Sang -- Circulació Àrees temàtiques de la UPC::Física |
| description |
Background The cortical microvascular cerebral blood flow response (CBF) to different changes in head-of-bed (HOB) position has been shown to be altered in acute ischemic stroke (AIS) by diffuse correlation spectroscopy (DCS) technique. However, the relationship between these relative ΔCBF changes and associated systemic blood pressure changes has not been studied, even though blood pressure is a major driver of cerebral blood flow. Methods Transcranial DCS data from four studies measuring bilateral frontal microvascular cerebral blood flow in healthy controls (n = 15), patients with asymptomatic severe internal carotid artery stenosis (ICA, n = 27), and patients with acute ischemic stroke (AIS, n = 72) were aggregated. DCS-measured CBF was measured in response to a short head-of-bed (HOB) position manipulation protocol (supine/elevated/supine, 5 min at each position). In a sub-group (AIS, n = 26; ICA, n = 14; control, n = 15), mean arterial pressure (MAP) was measured dynamically during the protocol. Results After elevated positioning, DCS CBF returned to baseline supine values in controls (p = 0.890) but not in patients with AIS (9.6% [6.0,13.3], mean 95% CI, p < 0.001) or ICA stenosis (8.6% [3.1,14.0], p = 0.003)). MAP in AIS patients did not return to baseline values (2.6 mmHg [0.5, 4.7], p = 0.018), but in ICA stenosis patients and controls did. Instead ipsilesional but not contralesional CBF was correlated with MAP (AIS 6.0%/mmHg [− 2.4,14.3], p = 0.038; ICA stenosis 11.0%/mmHg [2.4,19.5], p < 0.001). Conclusions The observed associations between ipsilateral CBF and MAP suggest that short HOB position changes may elicit deficits in cerebral autoregulation in cerebrovascular disorders. Additional research is required to further characterize this phenomenon. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 2021-04-09 2021 2021-06-18 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2117/347508 https://dx.doi.org/10.1186/s12883-021-02179-8 |
| url |
https://hdl.handle.net/2117/347508 https://dx.doi.org/10.1186/s12883-021-02179-8 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.relation.none.fl_str_mv |
Ministerio de Economía y Competitividad http://doi.org/10.13039/501100003329 DPI2015-64358-C2-1-R RED MULTIDISCIPLINAR DE TECNOLOGIAS OPTICAS NOVEDOSAS PARA LA TOMOGRAFIA NO INVASIVA DELA PERFUSION CEREBRAL COMO BIOMARCADOR EN PATOLOGIAS CEREBRALES Ministerio de Economía y Competitividad http://doi.org/10.13039/501100003329 DTS16%2F00087 MEDical PHOTonics platform for AGEing (MEDPHOTAGE): Plataforma fotónica, no invasiva, tipo "point-of-care", para la evaluación del riesgo cerebrovascular asociado con el envejecimiento Ministerio de Economía y Competitividad http://doi.org/10.13039/501100003329 SEV-2015-0522 AGR-INSTITUTO DE CIENCIAS FOTONICAS European Commission http://doi.org/10.13039/100010661 Horizon 2020 Framework Programme 654148 The Integrated Initiative of European Laser Research Infrastructures European Commission http://doi.org/10.13039/100010661 Horizon 2020 Framework Programme 654148 The Integrated Initiative of European Laser Research Infrastructures |
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open access http://purl.org/coar/access_right/c_abf2 Attribution 3.0 Spain http://creativecommons.org/licenses/by/3.0/es/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 Attribution 3.0 Spain http://creativecommons.org/licenses/by/3.0/es/ |
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openAccess |
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application/pdf |
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BMC |
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BMC |
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reponame:UPCommons. Portal del coneixement obert de la UPC instname:Universitat Politècnica de Catalunya (UPC) |
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Universitat Politècnica de Catalunya (UPC) |
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