The endocannabinoid 2-AG enhances spontaneous remyelination by targeting microglia

Remyelination is an endogenous process by which functional recovery of damaged neurons is achieved by reinstating the myelin sheath around axons. Remyelination has been documented in multiple sclerosis (MS) lesions and experimental models, although it is often incomplete or fails to affect the integ...

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Autores: Mecha Rodríguez, Miriam, Yanguas Casás, Natalia, Feliú Martínez, Ana, Mestre, L., Carrillo-Salinas, F., Azcoitia Elías, Iñigo, Yong, V. W., Guaza Rodríguez, Carmen
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/13507
Acceso en línea:https://hdl.handle.net/20.500.14352/13507
Access Level:acceso abierto
Palabra clave:576
Remyelination
Endocannabinoids
Microglia
Phagocytosis
TMEV
Biología celular (Biología)
2407 Biología Celular
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oai_identifier_str oai:docta.ucm.es:20.500.14352/13507
network_acronym_str ES
network_name_str España
repository_id_str
spelling The endocannabinoid 2-AG enhances spontaneous remyelination by targeting microgliaMecha Rodríguez, MiriamYanguas Casás, NataliaFeliú Martínez, AnaMestre, L.Carrillo-Salinas, F.Azcoitia Elías, IñigoYong, V. W.Guaza Rodríguez, Carmen576RemyelinationEndocannabinoidsMicrogliaPhagocytosisTMEVBiología celular (Biología)2407 Biología CelularRemyelination is an endogenous process by which functional recovery of damaged neurons is achieved by reinstating the myelin sheath around axons. Remyelination has been documented in multiple sclerosis (MS) lesions and experimental models, although it is often incomplete or fails to affect the integrity of the axon, thereby leading to progressive disability. Microglia play a crucial role in the clearance of the myelin debris produced by demyelination and in inflammation-dependent OPC activation, two processes necessary for remyelination to occur. We show here that following corpus callosum demyelination in the TMEV-IDD viral murine model of MS, there is spontaneous and partial remyelination that involves a temporal discordance between OPC mobilization and microglia activation. Pharmacological treatment with the endocannabinoid 2-AG enhances the clearance of myelin debris by microglia and OPC differentiation, resulting in complete remyelination and a thickening of the myelin sheath. These results highlight the importance of targeting microglia during the repair processes in order to enhance remyelination.ElsevierUniversidad Complutense de Madrid20192019-01-0120192019-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/13507reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución-NoComercial-SinDerivadas 3.0 Españahttps://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/135072026-06-02T12:44:21Z
dc.title.none.fl_str_mv The endocannabinoid 2-AG enhances spontaneous remyelination by targeting microglia
title The endocannabinoid 2-AG enhances spontaneous remyelination by targeting microglia
spellingShingle The endocannabinoid 2-AG enhances spontaneous remyelination by targeting microglia
Mecha Rodríguez, Miriam
576
Remyelination
Endocannabinoids
Microglia
Phagocytosis
TMEV
Biología celular (Biología)
2407 Biología Celular
title_short The endocannabinoid 2-AG enhances spontaneous remyelination by targeting microglia
title_full The endocannabinoid 2-AG enhances spontaneous remyelination by targeting microglia
title_fullStr The endocannabinoid 2-AG enhances spontaneous remyelination by targeting microglia
title_full_unstemmed The endocannabinoid 2-AG enhances spontaneous remyelination by targeting microglia
title_sort The endocannabinoid 2-AG enhances spontaneous remyelination by targeting microglia
dc.creator.none.fl_str_mv Mecha Rodríguez, Miriam
Yanguas Casás, Natalia
Feliú Martínez, Ana
Mestre, L.
Carrillo-Salinas, F.
Azcoitia Elías, Iñigo
Yong, V. W.
Guaza Rodríguez, Carmen
author Mecha Rodríguez, Miriam
author_facet Mecha Rodríguez, Miriam
Yanguas Casás, Natalia
Feliú Martínez, Ana
Mestre, L.
Carrillo-Salinas, F.
Azcoitia Elías, Iñigo
Yong, V. W.
Guaza Rodríguez, Carmen
author_role author
author2 Yanguas Casás, Natalia
Feliú Martínez, Ana
Mestre, L.
Carrillo-Salinas, F.
Azcoitia Elías, Iñigo
Yong, V. W.
Guaza Rodríguez, Carmen
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 576
Remyelination
Endocannabinoids
Microglia
Phagocytosis
TMEV
Biología celular (Biología)
2407 Biología Celular
topic 576
Remyelination
Endocannabinoids
Microglia
Phagocytosis
TMEV
Biología celular (Biología)
2407 Biología Celular
description Remyelination is an endogenous process by which functional recovery of damaged neurons is achieved by reinstating the myelin sheath around axons. Remyelination has been documented in multiple sclerosis (MS) lesions and experimental models, although it is often incomplete or fails to affect the integrity of the axon, thereby leading to progressive disability. Microglia play a crucial role in the clearance of the myelin debris produced by demyelination and in inflammation-dependent OPC activation, two processes necessary for remyelination to occur. We show here that following corpus callosum demyelination in the TMEV-IDD viral murine model of MS, there is spontaneous and partial remyelination that involves a temporal discordance between OPC mobilization and microglia activation. Pharmacological treatment with the endocannabinoid 2-AG enhances the clearance of myelin debris by microglia and OPC differentiation, resulting in complete remyelination and a thickening of the myelin sheath. These results highlight the importance of targeting microglia during the repair processes in order to enhance remyelination.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01
2019
2019-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/13507
url https://hdl.handle.net/20.500.14352/13507
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución-NoComercial-SinDerivadas 3.0 España
https://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución-NoComercial-SinDerivadas 3.0 España
https://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300719

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