Urban environment during early-life and blood pressure in young children

Background: The urban environment is characterised by many exposures that may influence hypertension development from early life onwards, but there is no systematic evaluation of their impact on child blood pressure (BP). Methods: Systolic and diastolic blood pressure were measured in 4,279 children...

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Detalles Bibliográficos
Autores: Warembourg, Charline, Nieuwenhuijsen, Mark J., Ballester Díez, Ferran, de Castro, Montserrat, Chatzi, Leda, Esplugues, Ana, Heude, Barbara, Maitre, Léa, McEachan, Rosemary R.C., Robinson, Oliver, Slama, Rémy, Sunyer Deu, Jordi, Urquiza, José M., Wright, John, Basagaña Flores, Xavier, Vrijheid, Martine
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/46304
Acceso en línea:http://hdl.handle.net/10230/46304
http://dx.doi.org/10.1016/j.envint.2020.106174
Access Level:acceso abierto
Palabra clave:Blood pressure
Children
Cohort
Urban environment
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network_name_str España
repository_id_str
dc.title.none.fl_str_mv Urban environment during early-life and blood pressure in young children
title Urban environment during early-life and blood pressure in young children
spellingShingle Urban environment during early-life and blood pressure in young children
Warembourg, Charline
Blood pressure
Children
Cohort
Urban environment
title_short Urban environment during early-life and blood pressure in young children
title_full Urban environment during early-life and blood pressure in young children
title_fullStr Urban environment during early-life and blood pressure in young children
title_full_unstemmed Urban environment during early-life and blood pressure in young children
title_sort Urban environment during early-life and blood pressure in young children
dc.creator.none.fl_str_mv Warembourg, Charline
Nieuwenhuijsen, Mark J.
Ballester Díez, Ferran
de Castro, Montserrat
Chatzi, Leda
Esplugues, Ana
Heude, Barbara
Maitre, Léa
McEachan, Rosemary R.C.
Robinson, Oliver
Slama, Rémy
Sunyer Deu, Jordi
Urquiza, José M.
Wright, John
Basagaña Flores, Xavier
Vrijheid, Martine
author Warembourg, Charline
author_facet Warembourg, Charline
Nieuwenhuijsen, Mark J.
Ballester Díez, Ferran
de Castro, Montserrat
Chatzi, Leda
Esplugues, Ana
Heude, Barbara
Maitre, Léa
McEachan, Rosemary R.C.
Robinson, Oliver
Slama, Rémy
Sunyer Deu, Jordi
Urquiza, José M.
Wright, John
Basagaña Flores, Xavier
Vrijheid, Martine
author_role author
author2 Nieuwenhuijsen, Mark J.
Ballester Díez, Ferran
de Castro, Montserrat
Chatzi, Leda
Esplugues, Ana
Heude, Barbara
Maitre, Léa
McEachan, Rosemary R.C.
Robinson, Oliver
Slama, Rémy
Sunyer Deu, Jordi
Urquiza, José M.
Wright, John
Basagaña Flores, Xavier
Vrijheid, Martine
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Blood pressure
Children
Cohort
Urban environment
topic Blood pressure
Children
Cohort
Urban environment
description Background: The urban environment is characterised by many exposures that may influence hypertension development from early life onwards, but there is no systematic evaluation of their impact on child blood pressure (BP). Methods: Systolic and diastolic blood pressure were measured in 4,279 children aged 4-5 years from a multi-centre European cohort (France, Greece, Spain, and UK). Urban environment exposures were estimated during pregnancy and childhood, including air pollution, built environment, natural spaces, traffic, noise, meteorology, and socioeconomic deprivation index. Single- and multiple-exposure linear regression models and a cluster analysis were carried out. Results: In multiple exposure models, higher child BP, in particular diastolic BP, was observed in association with higher exposure to air pollution, noise and ambient temperature during pregnancy, and with higher exposure to air pollution and higher building density during childhood (e.g., mean change [95% confidence interval] for an interquartile range increase in prenatal NO2 = 0.7 mmHg[0.3;1.2]). Lower BP was observed in association with higher temperature and better street connectivity during childhood (e.g., temperature = -1.1[-1.6;-0.6]). Some of these associations were not robust in the sensitivity analyses. Mother-child pairs were grouped into six urban environment exposure clusters. Compared to the cluster representing the least harmful urban environment, the two clusters representing the most harmful environment (high in air pollution, traffic, noise, and low in green space) were both associated with higher diastolic BP (1.3[0.1;2.6] and 1.5[0.5;2.5]). Conclusion: This first large systematic study suggests that living in a harmful urban environment may impact BP regulation in children. These findings reinforce the importance of designing cities that promote healthy environments to reduce long-term risk of hypertension and other cardiovascular diseases.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/46304
http://dx.doi.org/10.1016/j.envint.2020.106174
url http://hdl.handle.net/10230/46304
http://dx.doi.org/10.1016/j.envint.2020.106174
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Environ Int. 2021; 146:106174
info:eu-repo/grantAgreement/EC/FP7/308333
info:eu-repo/grantAgreement/EC/H2020/733206
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
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dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling Urban environment during early-life and blood pressure in young childrenWarembourg, CharlineNieuwenhuijsen, Mark J.Ballester Díez, Ferrande Castro, MontserratChatzi, LedaEsplugues, AnaHeude, BarbaraMaitre, LéaMcEachan, Rosemary R.C.Robinson, OliverSlama, RémySunyer Deu, JordiUrquiza, José M.Wright, JohnBasagaña Flores, XavierVrijheid, MartineBlood pressureChildrenCohortUrban environmentBackground: The urban environment is characterised by many exposures that may influence hypertension development from early life onwards, but there is no systematic evaluation of their impact on child blood pressure (BP). Methods: Systolic and diastolic blood pressure were measured in 4,279 children aged 4-5 years from a multi-centre European cohort (France, Greece, Spain, and UK). Urban environment exposures were estimated during pregnancy and childhood, including air pollution, built environment, natural spaces, traffic, noise, meteorology, and socioeconomic deprivation index. Single- and multiple-exposure linear regression models and a cluster analysis were carried out. Results: In multiple exposure models, higher child BP, in particular diastolic BP, was observed in association with higher exposure to air pollution, noise and ambient temperature during pregnancy, and with higher exposure to air pollution and higher building density during childhood (e.g., mean change [95% confidence interval] for an interquartile range increase in prenatal NO2 = 0.7 mmHg[0.3;1.2]). Lower BP was observed in association with higher temperature and better street connectivity during childhood (e.g., temperature = -1.1[-1.6;-0.6]). Some of these associations were not robust in the sensitivity analyses. Mother-child pairs were grouped into six urban environment exposure clusters. Compared to the cluster representing the least harmful urban environment, the two clusters representing the most harmful environment (high in air pollution, traffic, noise, and low in green space) were both associated with higher diastolic BP (1.3[0.1;2.6] and 1.5[0.5;2.5]). Conclusion: This first large systematic study suggests that living in a harmful urban environment may impact BP regulation in children. These findings reinforce the importance of designing cities that promote healthy environments to reduce long-term risk of hypertension and other cardiovascular diseases.This work was supported by funding from the European Community’s Seventh Framework Programme [FP7/2007–206 n°308333; the HELIX project], and by the European Union’s Horizon 2020 research and innovation programme [H2020 n°733206; the LifeCycle project]. CW holds a Sara Borrell fellowship from the Instituto de Salud Carlos III [CD18/00132]. INMA data collections were supported by grants from the Instituto de Salud Carlos III, CIBERESP, and the Generalitat de Catalunya- CIRIT (Spain). The Rhea project was financially supported by European projects, and the Greek Ministry of Health (Program of Prevention of obesity and neurodevelopmental disorders in preschool children, in Heraklion district, Crete, Greece: 2011–2014; “Rhea Plus”: Primary Prevention Program of Environmental Risk Factors for Reproductive Health, and Child Health: 2012–15). The work was also supported by MICINN [MTM2015-68140-R] and Centro Nacional de Genotipado- CEGEN- PRB2- ISCIII (Spain). This paper presents independent research funded by the National Institute for Health Research (NIHR) under its Collaboration for Applied Health Research and Care (CLAHRC) for Yorkshire and Humber (UK). Core support for Born in Bradford is also provided by the Wellcome Trust (WT101597MA, UK). The EDEN study was supported by Foundation for medical research (FRM), National Agency for Research (ANR), National Institute for Research in Public health (IRESP: TGIR cohorte santé 2008 program), French Ministry of Health (DGS), French Ministry of Research, INSERM Bone and Joint Diseases National Research (PRO-A), and Human Nutrition National Research Programs, Paris-Sud University, Nestlé, French National Institute for Population Health Surveillance (InVS), French National Institute for Health Education (INPES), the European Union FP7 programmes (ESCAPE, ENRIECO, Medall projects), Diabetes National Research Program (through a collaboration with the French Association of Diabetic Patients (AFD)), French Agency for Environmental Health Safety (now ANSES), Mutuelle Générale de l’Education Nationale a complementary health insurance (MGEN), French national agency for food security, French-speaking association for the study of diabetes and metabolism (ALFEDIAM).Elsevier202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/46304http://dx.doi.org/10.1016/j.envint.2020.106174reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésEnviron Int. 2021; 146:106174info:eu-repo/grantAgreement/EC/FP7/308333info:eu-repo/grantAgreement/EC/H2020/733206© 2020 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/)https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/463042026-05-29T05:05:01Z
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